-
1
-
-
46849089254
-
Recent developments in fragment-based drug discovery
-
Congreve, M.; Chessari, G.; Tisi, D.; Woodhead, A. J. Recent developments in fragment-based drug discovery J. Med. Chem. 2008, 51, 3661-3680
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3661-3680
-
-
Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
-
2
-
-
67649341990
-
From fragment to clinical candidate - A historical perspective
-
Chessari, G.; Woodhead, A. J. From fragment to clinical candidate-a historical perspective Drug Discovery Today 2009, 14, 668-675
-
(2009)
Drug Discovery Today
, vol.14
, pp. 668-675
-
-
Chessari, G.1
Woodhead, A.J.2
-
3
-
-
70349425790
-
Recent progress in fragment-based lead discovery
-
Schulz, M. N.; Hubbard, R. E. Recent progress in fragment-based lead discovery Curr. Opin. Pharmacol. 2009, 9, 615-621
-
(2009)
Curr. Opin. Pharmacol.
, vol.9
, pp. 615-621
-
-
Schulz, M.N.1
Hubbard, R.E.2
-
4
-
-
37848998796
-
Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation
-
Geschwindner, S.; Olsson, L.-L.; Albert, J.-S.; Deinum, J.; Edwards, P. D.; de Beer, T.; Folmer, R. H. A. Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation J. Med. Chem. 2007, 50 (24) 5903-5911
-
(2007)
J. Med. Chem.
, vol.50
, Issue.24
, pp. 5903-5911
-
-
Geschwindner, S.1
Olsson, L.-L.2
Albert, J.-S.3
Deinum, J.4
Edwards, P.D.5
De Beer, T.6
Folmer, R.H.A.7
-
5
-
-
36249028775
-
SPR-based fragment screening: Advantages and applications
-
Neumann, T.; Junker, H. D.; Schmidt, K.; Sekul, R. SPR-based fragment screening: advantages and applications Curr. Top. Med. Chem. 2007, 7, 1630-1642
-
(2007)
Curr. Top. Med. Chem.
, vol.7
, pp. 1630-1642
-
-
Neumann, T.1
Junker, H.D.2
Schmidt, K.3
Sekul, R.4
-
6
-
-
39049094722
-
Tyramine fragment binding to BACE-1
-
Kuglstatter, A.; Martin Stahl, M.; Jens-Uwe Peters, J.-U.; Walter Huber, W.; Martine Stihle, M.; Daniel Schlatter, D.; Jörg Benz, J.; Armin Ruf, A.; Doris Roth, D.; Thilo Enderle, T.; Michael Hennig, M. Tyramine fragment binding to BACE-1 Bioorg. Med. Chem. Lett. 2008, 18, 1304-1307
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 1304-1307
-
-
Kuglstatter, A.1
Martin Stahl, M.2
Jens-Uwe Peters, J.-U.3
Walter Huber, W.4
Martine Stihle, M.5
Daniel Schlatter, D.6
Jörg Benz, J.7
Armin Ruf, A.8
Doris Roth, D.9
Thilo Enderle, T.10
Michael Hennig, M.11
-
7
-
-
45749114201
-
Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library
-
Nordström, H.; Gossas, T.; Hämäläinen, M.; Kälblad, P.; Nyström, S.; Wallberg, H.; Danielson, U. H. Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library J. Med. Chem. 2008, 51, 3349-3459
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3349-3459
-
-
Nordström, H.1
Gossas, T.2
Hämäläinen, M.3
Kälblad, P.4
Nyström, S.5
Wallberg, H.6
Danielson, U.H.7
-
8
-
-
40049083268
-
Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels
-
Hämäläinen, M. D.; Zhukov, A.; Ivarsson, M.; Fex, T.; Gottfries, J.; Karlsson, R.; Björsne, M. Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels J. Biomol. Screening 2008, 13, 202-209
-
(2008)
J. Biomol. Screening
, vol.13
, pp. 202-209
-
-
Hämäläinen, M.D.1
Zhukov, A.2
Ivarsson, M.3
Fex, T.4
Gottfries, J.5
Karlsson, R.6
Björsne, M.7
-
9
-
-
74249116139
-
Fragment Library Screening and Lead Characterization using SPR Biosensors
-
in press.
-
Danielson, U. H. Fragment Library Screening and Lead Characterization using SPR Biosensors. Curr. Top. Med. Chem., in press.
-
Curr. Top. Med. Chem.
-
-
Danielson, U.H.1
-
10
-
-
65449148686
-
Fragment-based screening using surface plasmon resonace technology
-
Perspicase, S.; Banner, D.; Benz, J.; Müller, F.; Schlatter, D.; Huber, W. Fragment-based screening using surface plasmon resonace technology J. Biomol. Screening 2009, 14, 337-349
-
(2009)
J. Biomol. Screening
, vol.14
, pp. 337-349
-
-
Perspicase, S.1
Banner, D.2
Benz, J.3
Müller, F.4
Schlatter, D.5
Huber, W.6
-
11
-
-
33947666565
-
Thermodynamic benchmark study using Biacore technology
-
Navratilova, I.; Papalia, G. A.; Rich, R. L.; Bedinger, D.; Brophy, S.; Condon, B.; Deng, T.; Emerick, A. W.; Guan, H. W.; Hayden, T.; Heutmekers, T.; Hoorelbeke, B.; McCroskey, M. C.; Murphy, M. M.; Nakagawa, T.; Parmeggiani, F.; Qin, X.; Rebe, S.; Tomasevic, N.; Tsang, T.; Waddell, M. B.; Zhang, F. F.; Leavitt, S.; Myszka, D. G. Thermodynamic benchmark study using Biacore technology Anal. Biochem. 2007, 364, 67-77
-
(2007)
Anal. Biochem.
, vol.364
, pp. 67-77
-
-
Navratilova, I.1
Papalia, G.A.2
Rich, R.L.3
Bedinger, D.4
Brophy, S.5
Condon, B.6
Deng, T.7
Emerick, A.W.8
Guan, H.W.9
Hayden, T.10
Heutmekers, T.11
Hoorelbeke, B.12
McCroskey, M.C.13
Murphy, M.M.14
Nakagawa, T.15
Parmeggiani, F.16
Qin, X.17
Rebe, S.18
Tomasevic, N.19
Tsang, T.20
Waddell, M.B.21
Zhang, F.F.22
Leavitt, S.23
Myszka, D.G.24
more..
-
12
-
-
40449118501
-
Applications of Binding Kinetics to Drug Discovery: Translation of Binding Mechanisms to Clinically Differentiated Therapeutic Responses
-
Swinney, D. C. Applications of Binding Kinetics to Drug Discovery: Translation of Binding Mechanisms to Clinically Differentiated Therapeutic Responses Pharm. Med. 2008, 22, 23-34
-
(2008)
Pharm. Med.
, vol.22
, pp. 23-34
-
-
Swinney, D.C.1
-
13
-
-
52049123291
-
Do enthalpy and entropy distinguish first in class from best in class?
-
Freire, E. Do enthalpy and entropy distinguish first in class from best in class? Drug Discovery Today 2008, 13, 869-874
-
(2008)
Drug Discovery Today
, vol.13
, pp. 869-874
-
-
Freire, E.1
-
14
-
-
1942453243
-
Ligand efficiency: A useful metric for lead selection
-
Hopkins, A. L.; Groom, C. R.; Alex, A. Ligand efficiency: a useful metric for lead selection Drug Discovery Today 2004, 9, 430-431
-
(2004)
Drug Discovery Today
, vol.9
, pp. 430-431
-
-
Hopkins, A.L.1
Groom, C.R.2
Alex, A.3
-
15
-
-
33751119041
-
Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology
-
Papalia, G. A.; Leavitt, S.; Bynum, M. A.; Katsamba, P. S.; Wilton, R.; Qiu, H.; Steukers, M.; Wang, S.; Bindu, L.; Phogat, S.; Giannetti, A. M.; Ryan, T. E.; Pudlak, V. A.; Matusiewicz, K.; Michelson, K. M.; Nowakowski, A.; Pham-Baginski, A.; Brooks, J.; Tieman, B. C.; Bruce, B. D.; Vaughn, M.; Baksh, M.; Cho, Y. H.; Wit, M. D.; Smets, A.; Vandersmissen, J.; Michiels, L.; Myszka, D. G. Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology Anal. Biochem. 2006, 359, 94-105
-
(2006)
Anal. Biochem.
, vol.359
, pp. 94-105
-
-
Papalia, G.A.1
Leavitt, S.2
Bynum, M.A.3
Katsamba, P.S.4
Wilton, R.5
Qiu, H.6
Steukers, M.7
Wang, S.8
Bindu, L.9
Phogat, S.10
Giannetti, A.M.11
Ryan, T.E.12
Pudlak, V.A.13
Matusiewicz, K.14
Michelson, K.M.15
Nowakowski, A.16
Pham-Baginski, A.17
Brooks, J.18
Tieman, B.C.19
Bruce, B.D.20
Vaughn, M.21
Baksh, M.22
Cho, Y.H.23
Wit, M.D.24
Smets, A.25
Vandersmissen, J.26
Michiels, L.27
Myszka, D.G.28
more..
-
16
-
-
47749106894
-
Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors
-
Coan, K. E. D.; Shoichet, B. K. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors J. Am. Chem. Soc. 2008, 130, 9606-9612
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 9606-9612
-
-
Coan, K.E.D.1
Shoichet, B.K.2
-
17
-
-
39149130730
-
Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors
-
Giannetti, A. M.; Koch, B. D.; Browner, M. F. Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors J. Med. Chem. 2008, 51, 574-80
-
(2008)
J. Med. Chem.
, vol.51
, pp. 574-80
-
-
Giannetti, A.M.1
Koch, B.D.2
Browner, M.F.3
-
18
-
-
67650999672
-
Lessons for fragment library design: Analysis of output from multiple screening campaigns
-
In Press.
-
Chen, I.-J.; Hubbard, R. E. Lessons for fragment library design: analysis of output from multiple screening campaigns J. Comput.-Aided Mol. Des. 2009, In Press.
-
(2009)
J. Comput.-Aided Mol. Des.
-
-
Chen, I.-J.1
Hubbard, R.E.2
-
19
-
-
17144373303
-
Druggability Indices for Protein Targets Derived from NMR-Based Screening Data
-
Hajduk, P. J.; Huth, J. R.; Fesik, S. W. Druggability Indices for Protein Targets Derived from NMR-Based Screening Data J. Med. Chem. 2005, 48, 2518-2525
-
(2005)
J. Med. Chem.
, vol.48
, pp. 2518-2525
-
-
Hajduk, P.J.1
Huth, J.R.2
Fesik, S.W.3
-
20
-
-
29144483936
-
Predicting protein druggability
-
Hajduk, P. J.; Huth, J. R.; Tse, C. Predicting protein druggability Drug Discovery Today 2005, 10, 1675-1682
-
(2005)
Drug Discovery Today
, vol.10
, pp. 1675-1682
-
-
Hajduk, P.J.1
Huth, J.R.2
Tse, C.3
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