Binding or bending: Distinction of allosteric abl kinase agonists from antagonists by an NMR-based conformational assay

Journal of the American Chemical Society

Volumn 132, Issue 20, 2010, Pages 7043-7048

  Jahnke, Wolfgang ^a   Grotzfeld, Robert M ^a   Pellé, Xavier ^a   Strauss, André ^a   Fendrich, Gabriele ^a   Cowan Jacob, Sandra W ^a   Cotesta, Simona ^a   Fabbro, Doriano ^a   Furet, Pascal ^a   Mestan, Jürgen ^a   Marzinzik, Andreas L ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; BIOCHEMICAL ASSAY; CONFORMATIONAL CHANGE; CONFORMATIONAL STATE; FUNCTIONAL ACTIVITIES; STRUCTURAL DETERMINANTS;

LIGANDS;

ABELSON KINASE; BCR ABL PROTEIN;

ALLOSTERISM; ARTICLE; CHEMICAL ANALYSIS; CONFORMATION; ENZYME ACTIVITY; ENZYME BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ALLOSTERIC REGULATION; ANIMALS; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MYRISTIC ACID; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-ABL;

EID: 77952575338     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja101837n     Document Type: Article

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