Synthesis, characterization, and urease inhibition of 5-substituted-8- methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-diones

Medicinal Chemistry Research

Volumn 21, Issue 1, 2012, Pages 60-74

  Rauf, Abdul ^a   Liaqat, Sumaira ^a   Qureshi, Ashfaq M ^b   Yaqub, Muhammad ^b   Rehman, Aziz U ^a   Hassan, Mahmood U ^c   Chohan, Zahid H ^b   Nasim, Faiz U H ^a   Hadda, T Ben ^d  

^a THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^b BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^c Government S E College   (Pakistan)

^d FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Anti urease; Dimroth rearrangement; Pyridopyrimidines; Virtual screening

Indexed keywords

3 [(2 ACETYLANILINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(2 FLUOROANILINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(3 ACETYLANILINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(3 FLUOROANILINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(4 ACETYLANILINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(4 FLUOROANILINO)METHYLIDENE 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 3 [(MESITYLAMINO)METHYLIDENE] 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 4 BROMO N' [[8 METHYL 2,4 DIOXO 2H PYRIDO[1,2 A]PYRIMIN 3 (4H) YLIDENE]METHYL]BENZOHYDRAZIDE; 4 CHLORO N' [[8 METHYL 2,4 DIOXO 2H PYRIDO[1,2 A]PYRIMIDIN 3 (4H) YLIDENE]METHYL]BENZOHYDRAZIDE; 4 HYDROXY N' [[8 METHYL 2,4 DIOXO 2H PYRIDO[1,2 A]PYRIMIDIN 3 (4H) YLIDENE]METHYL]BENZOHYDRAZIDE; 4 NITRO N' [[8 METHYL 2,4 DIOXO 2H PYRIDO[1,2 A]PYRIMIDIN 3 (4H) YLIDENE]METHYL]BENZOHYDRAZIDE; 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 (3H) DIONE; 8 METHYL 3 [(2 SULFANYLANILINO)METHYLIDENE] 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; 8 METHYL 3 [[(4 METHYL 2 PYRIDINYL)AMINO]METHYLIDENE] 2H PYRIDO[1,2]PYRIMIDINE 2,4 DIONE; 8 METHYL 3 [[(5 METHYL 2 PYRIDINYL)AMINO]METHYLIDENE] 2H PYRIDO[1,2]PYRIMIDINE 2,4 DIONE; 8 METHYL 3 [[(5 NITRO 2 PYRIDINYL)AMINO]METHYLIDENE] 2H PYRIDO[1,2 A]PYRIMIDINE 2,4 DIONE; ANILINE; FORMAMIDE DERIVATIVE; HYDRAZIDE; HYPOCHLORITE; N' [[8 METHYL 2,4 DIOXO 2H PYRIDO[1,2 A]PYRIMIDIN 3 (4H) YLIDENE]METHYL]BENZO HYDRAZIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREASE; UREASE INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; TAUTOMERIZATION;

EID: 84856235990     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9491-2     Document Type: Article

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