Antimitotic antitumor agents: Synthesis, structure-activity relationships, and biological characterization of N-aryl-N′-(2-chloroethyl)ureas as new selective alkylating agents

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 694-702

  Mounetou, E ^a   Legault, J ^a   Lacroix, J ^b   C Gaudreault, R ^b  

^a INSERM   (France)

^b Université Laval   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; BETA TUBULIN; GLUTATHIONE; GLUTATHIONE REDUCTASE; N (4 IDODOPHENYL) N' 2 CHLOROETHYLUREA; N (4 ISOPROPYLPHENYL N' 2 CHLOROETHYLUREA; N (4 SEC BUTYLPHENYL) N' 2 CHLOROETHYLUREA; N (4 TERT BUTYLPHENYL) N' 2 CHLOROETHYLUREA; THIOL GROUP; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALKYLATION; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; DEPOLYMERIZATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MICROTUBULE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CRICETINAE; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROTUBULES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED; UREA;

EID: 0035282634     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0010264     Document Type: Article

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