6-thienyl and 6-phenylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase

European Journal of Medicinal Chemistry

Volumn 34, Issue 10, 1999, Pages 883-889

  Andreani, Aldo ^a   Rambaldi, Mirella ^a   Leoni, Alberto ^a   Morigi, Rita ^a   Locatelli, Alessandra ^a   Giorgi, Gianluca ^b   Lenaz, Giorgio ^c   Ghelli, Anna ^d   Degli Esposti, Mauro ^e  

^a Dipto di Scienze Farmaceutiche   (Italy)

^b Ctro Interdipartimentale Analisi D   (Italy)

^c Dipto di Biochim Giovanni Moruzzi   (Italy)

^d Dip Biologia ES   (Italy)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Imidazo 2,1 b thiazole; Mitochondrial complex I; Rotenone; Ubiquinone

Indexed keywords

6 PHENYLIMIDAZO[2,1 B]THIAZOLE DERIVATIVE; ENZYME INHIBITOR; MYXOTHIAZOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE INHIBITOR; ROTENONE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; MITOCHONDRIAL RESPIRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0032693483     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00203-2     Document Type: Article

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