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Volumn 66, Issue 1, 2012, Pages 85-94

Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: Comparison with glutathione modifiers

Author keywords

Cellular redox; Cyclooxygenase 2; Glutathione; Inducible nitric oxide synthase; Mesenchymal stem cells; Proliferation; Silymarin

Indexed keywords

ACETYLCYSTEINE; AGENTS AFFECTING PROTEIN METABOLISM; BUTHIONINE SULFOXAMINE; CYCLOOXYGENASE 2; GLUTATHIONE; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; SILYMARIN; UNCLASSIFIED DRUG;

EID: 84856209536     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-011-0554-6     Document Type: Article
Times cited : (18)

References (55)
  • 1
    • 11144237925 scopus 로고    scopus 로고
    • 2-terminal kinase and Janus kinase/signal transducer and activator of transcription pathways
    • DOI 10.1210/en.2004-0850
    • Matsuda T, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y (2005) Silymarin protects pancreatic b-cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and janus kinase/signal transducer and activator of transcription pathways. Endocrinology 146(1):175-185 (Pubitemid 40051737)
    • (2005) Endocrinology , vol.146 , Issue.1 , pp. 175-185
    • Matsuda, T.1    Ferreri, K.2    Todorov, I.3    Kuroda, Y.4    Smith, C.V.5    Kandeel, F.6    Mullen, Y.7
  • 4
    • 0036372619 scopus 로고    scopus 로고
    • Redox potential of GSH/GSSG couple: Assay and biological significance
    • DOI 10.1016/S0076-6879(02)48630-2, 11, Part B: Protein Sensors and Reactive Oxygen Species
    • Jones DP (2002) Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol 348:93-112 (Pubitemid 41103102)
    • (2002) Methods in Enzymology , vol.348 , pp. 93-112
    • Jones, D.P.1
  • 5
    • 0142107437 scopus 로고    scopus 로고
    • Redox state of glutathione and thioredoxin in differentiation and apoptosis
    • Walter HW, Yan C, Dean PJ (2003) Redox state of glutathione and thioredoxin in differentiation and apoptosis. BioFactors 17:307-314
    • (2003) BioFactors , vol.17 , pp. 307-314
    • Walter, H.W.1    Yan, C.2    Dean, P.J.3
  • 6
    • 84856225023 scopus 로고    scopus 로고
    • Distinct roles of different nitric oxide synthase isoforms in regulating hematopoietic stem cell function in vivo
    • Yuan Y, Tzeng E, Billiar TR (2006) Distinct roles of different nitric oxide synthase isoforms in regulating hematopoietic stem cell function in vivo. Nitric Oxide 14:7
    • (2006) Nitric Oxide , vol.14 , pp. 7
    • Yuan, Y.1    Tzeng, E.2    Billiar, T.R.3
  • 7
    • 70349974675 scopus 로고    scopus 로고
    • Tissue-specific stem cells adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells
    • Lee HW, Kim SY, Kim AY, Lee EJ, Choi JY, Kim JB (2009) Tissue-specific stem cells adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells. Stem Cells 27(9):2254-2262
    • (2009) Stem Cells , vol.27 , Issue.9 , pp. 2254-2262
    • Lee, H.W.1    Kim, S.Y.2    Kim, A.Y.3    Lee, E.J.4    Choi, J.Y.5    Kim, J.B.6
  • 8
    • 0023848599 scopus 로고
    • Interleukin 1: A mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids
    • Libby P, Warner SJ, Friedman GB (1988) Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth inhibitory prostanoids. J Clin Invest 81:487-498 (Pubitemid 18075245)
    • (1988) Journal of Clinical Investigation , vol.81 , Issue.2 , pp. 487-498
    • Libby, P.1    Warner, S.J.C.2    Friedman, G.B.3
  • 9
    • 0030906311 scopus 로고    scopus 로고
    • Roles of vasodilatory prostaglandins in mitogenesis of vascular smooth muscle cells
    • Schror K, Weber AA (1997) Roles of vasodilatory prostaglandins in mitogenesis of vascular smooth muscle cells. Agents Actions Suppl 48:63-91 (Pubitemid 27230356)
    • (1997) Agents and Actions Supplements , vol.48 , pp. 63-91
    • Schror, K.1    Weber, A.-A.2
  • 10
    • 0031906154 scopus 로고    scopus 로고
    • Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells
    • Yan Z, Hansson GK (1998) Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells. Circ Res 82:21-29 (Pubitemid 28074015)
    • (1998) Circulation Research , vol.82 , Issue.1 , pp. 21-29
    • Yan, Z.-Q.1    Hansson, G.K.2
  • 11
    • 0031193675 scopus 로고    scopus 로고
    • Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels
    • DOI 10.1006/jmcc.1996.0480
    • Rizvi MA, Myers PR (1997) Nitric oxide modulates basal and endothein-induced coronary artery vascular smooth muscle cell proliferation and collagen levels. J Mol Cell Cardiol 29:1779-1789 (Pubitemid 27303084)
    • (1997) Journal of Molecular and Cellular Cardiology , vol.29 , Issue.7 , pp. 1779-1789
    • Rizvi, M.A.D.1    Myers, P.R.2
  • 12
    • 0030786408 scopus 로고    scopus 로고
    • Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts
    • DOI 10.1016/S0014-5793(97)00544-9, PII S0014579397005449
    • Gansauge S, Gansauge F, Nussler AK, Rau B, Poch B, Schoenberg MH, Beger HG (1997) Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts. FEBS Lett 410:160-164 (Pubitemid 27304056)
    • (1997) FEBS Letters , vol.410 , Issue.2-3 , pp. 160-164
    • Gansauge, S.1    Gansauge, F.2    Nussler, A.K.3    Rau, B.4    Poch, B.5    Schoenberg, M.H.6    Beger, H.G.7
  • 13
    • 15944362773 scopus 로고    scopus 로고
    • Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration
    • DOI 10.1016/j.surg.2004.12.003
    • Sigala F, Papalambros E, Kotsinas A, Andreadou I, Sigalas P, Kremastinos D, Bastounis E, Gorgoulis VG (2005) Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration. Surgery 137(4):447-456 (Pubitemid 40432044)
    • (2005) Surgery , vol.137 , Issue.4 , pp. 447-456
    • Sigala, F.1    Papalambros, E.2    Kotsinas, A.3    Andreadou, I.4    Sigalas, P.5    Kremastinos, D.6    Bastounis, E.7    Gorgoulis, V.G.8
  • 14
    • 3543109116 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: Correlation with microvessel density
    • Kasper HU, Wolf H, Drebber U, Wolf HK, Kern MA (2004) Expression of inducible nitric oxide synthase and cyclooxygenase- 2 in pancreatic adenocarcinoma: correlation with microvessel density. World J Gastroenterol 10(13):1918-1922 (Pubitemid 39029293)
    • (2004) World Journal of Gastroenterology , vol.10 , Issue.13 , pp. 1918-1922
    • Kasper, H.U.1    Wolf, H.2    Drebber, U.3    Wolf, H.K.4    Kern, M.A.5
  • 17
    • 0036085857 scopus 로고    scopus 로고
    • Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages
    • DOI 10.1124/jpet.302.1.138
    • Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH (2002) Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 302(1):138-144 (Pubitemid 34680431)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.302 , Issue.1 , pp. 138-144
    • Kang, J.S.1    Jeon, Y.J.2    Kim, H.M.3    Han, S.H.4    Yang, K.-H.5
  • 18
    • 0032713528 scopus 로고    scopus 로고
    • Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: Implications in the prevention of stage I tumor promotion
    • Zhao J, Sharma Y, Agarwal R (1999) Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol Carcinog 26(4):321-333
    • (1999) Mol Carcinog , vol.26 , Issue.4 , pp. 321-333
    • Zhao, J.1    Sharma, Y.2    Agarwal, R.3
  • 20
    • 0034859659 scopus 로고    scopus 로고
    • Silymarin: A review of its clinical properties in the management of hepatic disorders
    • Wellington K, Jarvis B (2001) Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 15(7):465-489 (Pubitemid 32783707)
    • (2001) BioDrugs , vol.15 , Issue.7 , pp. 465-489
    • Wellington, K.1    Adis, B.J.2
  • 21
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C (2006) Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 124(5):491-504 (Pubitemid 46157708)
    • (2006) Indian Journal of Medical Research , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 23
    • 34250667940 scopus 로고    scopus 로고
    • Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis
    • DOI 10.1080/10286020600604260, PII 779554012
    • Li LH, Wu LJ, Tashiro SI, Onodera S, Uchiumi F, Ikejima T (2007) Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UVinduced A375-S2 cell apoptosis. J Asian Nat Prod Res 9:245-252 (Pubitemid 46933325)
    • (2007) Journal of Asian Natural Products Research , vol.9 , Issue.3 , pp. 245-252
    • Li, L.-H.1    Wu, L.-J.2    Tashiro, S.-I.3    Onodera, S.4    Uchiumi, F.5    Ikejima, T.6
  • 24
    • 35848966581 scopus 로고    scopus 로고
    • P21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells
    • DOI 10.1158/1535-7163.MCT-07-0104
    • Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R (2007) p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther 6(10):2696-2707 (Pubitemid 350058150)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.10 , pp. 2696-2707
    • Roy, S.1    Kaur, M.2    Agarwal, C.3    Tecklenburg, M.4    Sclafani, R.A.5    Agarwal, R.6
  • 25
    • 68849113912 scopus 로고    scopus 로고
    • Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
    • Kaur M, Velmurugan B, Tyagi A, Deep G, Katiyar S, Agarwal C, Agarwal R (2009) Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol Cancer Ther 8(8):2366-2374
    • (2009) Mol Cancer Ther , vol.8 , Issue.8 , pp. 2366-2374
    • Kaur, M.1    Velmurugan, B.2    Tyagi, A.3    Deep, G.4    Katiyar, S.5    Agarwal, C.6    Agarwal, R.7
  • 26
    • 43949126193 scopus 로고    scopus 로고
    • Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells
    • DOI 10.1002/ijc.23485
    • Deep G, Oberlies NH, Kroll DJ, Agarwal RI (2008) Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int J Cancer 123(1):41-50 (Pubitemid 351705190)
    • (2008) International Journal of Cancer , vol.123 , Issue.1 , pp. 41-50
    • Deep, G.1    Oberlies, N.H.2    Kroll, D.J.3    Agarwal, R.4
  • 28
    • 33244472101 scopus 로고    scopus 로고
    • Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin
    • DOI 10.1038/sj.onc.1209146, PII 1209146
    • Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R (2006) Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 25(7):1053-1069 (Pubitemid 43277013)
    • (2006) Oncogene , vol.25 , Issue.7 , pp. 1053-1069
    • Deep, G.1    Singh, R.P.2    Agarwal, C.3    Kroll, D.J.4    Agarwal, R.5
  • 31
    • 33744980639 scopus 로고    scopus 로고
    • Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from β-thalassemia major patients
    • DOI 10.1016/j.intimp.2006.04.004, PII S1567576906001214
    • Alidoost F, Gharagozloo M, Bagherpour B, Jafarian A, Sajjadi SE, Hourfar H, Moayedi B (2006) Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from b-thalassemia major patients. Int Immunopharmacol 6(8):1305-1310 (Pubitemid 43868191)
    • (2006) International Immunopharmacology , vol.6 , Issue.8 , pp. 1305-1310
    • Alidoost, F.1    Gharagozloo, M.2    Bagherpour, B.3    Jafarian, A.4    Sajjadi, S.E.5    Hourfar, H.6    Moayedi, B.7
  • 32
    • 4344629494 scopus 로고    scopus 로고
    • 1 despite increasing accumulation of free sphingoid bases
    • DOI 10.1093/toxsci/kfh148
    • He Q, Kim J, Sharma RP (2004) Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. Toxicol Sci 80(2):335-342 (Pubitemid 39136388)
    • (2004) Toxicological Sciences , vol.80 , Issue.2 , pp. 335-342
    • He, Q.1    Kim, J.2    Sharma, R.P.3
  • 33
    • 34249907027 scopus 로고    scopus 로고
    • Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.)
    • DOI 10.1177/1534735407301942
    • Tamayo C, Diamond S (2007) Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.). Integr Cancer Ther 6(2):146-157 (Pubitemid 46871845)
    • (2007) Integrative Cancer Therapies , vol.6 , Issue.2 , pp. 146-157
    • Tamayo, C.1    Diamond, S.2
  • 34
    • 64749101022 scopus 로고    scopus 로고
    • Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin
    • Tunca R, Sozmen M, Citil M, Karapehlivan M, Erginsoy S, Yapar K (2009) Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin. Exp Toxicol Pathol 61(3):243-255
    • (2009) Exp Toxicol Pathol , vol.61 , Issue.3 , pp. 243-255
    • Tunca, R.1    Sozmen, M.2    Citil, M.3    Karapehlivan, M.4    Erginsoy, S.5    Yapar, K.6
  • 35
    • 51049109239 scopus 로고    scopus 로고
    • Silibinin inhibits cytokine-induced signaling cascades and downregulates inducible nitric oxide synthase in human lung carcinoma A549 cells
    • Chittezhath M, Deep G, Singh RP, Agarwal C, Agarwal R (2008) Silibinin inhibits cytokine-induced signaling cascades and downregulates inducible nitric oxide synthase in human lung carcinoma A549 cells. Mol Cancer Ther 7(7):1817-1826
    • (2008) Mol Cancer Ther , vol.7 , Issue.7 , pp. 1817-1826
    • Chittezhath, M.1    Deep, G.2    Singh, R.P.3    Agarwal, C.4    Agarwal, R.5
  • 37
    • 58849147591 scopus 로고    scopus 로고
    • Biochemical and molecular characterization of hepatocyte-like cells derived from human bone marrow mesenchymal stem cells on a novel three-dimensional biocompatible nanofibrous scaffold
    • Kazemnejad S, Allameh A, Soleimani M, Gharehbaghian A, Mohammadi Y, Amirizadeh N, Jazayery M (2009) Biochemical and molecular characterization of hepatocyte-like cells derived from human bone marrow mesenchymal stem cells on a novel three-dimensional biocompatible nanofibrous scaffold. J Gastroentrol Hepatol 24:278-287
    • (2009) J Gastroentrol Hepatol , vol.24 , pp. 278-287
    • Kazemnejad, S.1    Allameh, A.2    Soleimani, M.3    Gharehbaghian, A.4    Mohammadi, Y.5    Amirizadeh, N.6    Jazayery, M.7
  • 40
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 41
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502-522
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 42
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 43
    • 78649985231 scopus 로고    scopus 로고
    • Increasing rate of human bone marrow mesenchymal stem cell proliferation in the presence of silymarin
    • Ahmadi-Ashtiani HR, Allameh A, Hamidipour N, Rastegar H, Soleimani M (2010) Increasing rate of human bone marrow mesenchymal stem cell proliferation in the presence of silymarin. J Med Plants 9(34):156-164
    • (2010) J Med Plants , vol.9 , Issue.34 , pp. 156-164
    • Ahmadi-Ashtiani, H.R.1    Allameh, A.2    Hamidipour, N.3    Rastegar, H.4    Soleimani, M.5
  • 44
    • 35848954756 scopus 로고    scopus 로고
    • Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells
    • DOI 10.1002/jcp.21145
    • Iemata M, Takarada T, Hinoi E, Taniura H, Yoneda Y (2007) Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cysteine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells. J Cell Physiol 213:721-729 (Pubitemid 350058265)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.3 , pp. 721-729
    • Iemata, M.1    Takarada, T.2    Hinoi, E.3    Taniura, H.4    Yoneda, Y.5
  • 45
    • 0034730151 scopus 로고    scopus 로고
    • Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
    • Smith J, Ladi E, Mayer-Pröschel M, Noble M (2000) Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci USA 97(18):10032-10037
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.18 , pp. 10032-10037
    • Smith, J.1    Ladi, E.2    Mayer-Pröschel, M.3    Noble, M.4
  • 46
    • 0024455859 scopus 로고
    • Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat
    • Valenzuela A, Aspillaga M, Vial S, Guerra R (1989) Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med 55(5):420-422 (Pubitemid 19249809)
    • (1989) Planta Medica , vol.55 , Issue.5 , pp. 420-422
    • Valenzuela, A.1    Aspillaga, M.2    Vial, S.3    Guerra, R.4
  • 47
    • 77950523031 scopus 로고    scopus 로고
    • Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage
    • Ji AR, Ku SY, Cho MS, Kim YY, Kim YJ, Oh SK, Kim SH, Moon SY, Choi YM (2010) Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage. Exp Mol Med 42:175-186
    • (2010) Exp Mol Med , vol.42 , pp. 175-186
    • Ji, A.R.1    Ku, S.Y.2    Cho, M.S.3    Kim, Y.Y.4    Kim, Y.J.5    Oh, S.K.6    Kim, S.H.7    Moon, S.Y.8    Choi, Y.M.9
  • 48
    • 33645232043 scopus 로고    scopus 로고
    • Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts
    • Ho YC, Chang YC (2006) Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Acta Pharmacol Sin 27(4):409-413
    • (2006) Acta Pharmacol Sin , vol.27 , Issue.4 , pp. 409-413
    • Ho, Y.C.1    Chang, Y.C.2
  • 49
    • 0033163137 scopus 로고    scopus 로고
    • Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: Species variation
    • Jourdan KB, Evans TW, Lamb NJ, Goldstraw P, Mitchell JA (1999) Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells. Am J Respir Cell Mol Biol 21(1):105-110 (Pubitemid 129508633)
    • (1999) American Journal of Respiratory Cell and Molecular Biology , vol.21 , Issue.1 , pp. 105-110
    • Jourdan, K.B.1    Evans, T.W.2    Lamb, N.J.3    Goldstraw, P.4    Mitchell, J.A.5
  • 51
    • 33746136946 scopus 로고    scopus 로고
    • Overexpression of Cox-2 in human osteosarcoma cells decreases proliferation and increases apoptosis
    • DOI 10.1158/0008-5472.CAN-05-3624
    • Xu Z, Choudhary S, Voznesensky O, Mehrotra M, Woodard M, Hansen M, Herschman H, Pilbeam C (2006) Overexpression of Cox-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. Cancer Res 66(13):6657-6664 (Pubitemid 44085622)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6657-6664
    • Xu, Z.1    Choudhary, S.2    Voznesensky, O.3    Mehrotra, M.4    Woodard, M.5    Hansen, M.6    Herschman, H.7    Pilbeam, C.8
  • 52
    • 53149114099 scopus 로고    scopus 로고
    • ShRNA-targeted cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells
    • Wang R, Wang X, Lin F, Gao P, Dong K, Zhang HZ (2008) shRNA-targeted cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells. Mol Cell Biochem 317:179-188
    • (2008) Mol Cell Biochem , vol.317 , pp. 179-188
    • Wang, R.1    Wang, X.2    Lin, F.3    Gao, P.4    Dong, K.5    Zhang, H.Z.6
  • 53
    • 33747377104 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation
    • Collesellia D, Bijuklicb K, Mosheimerb BA, Kählera CM (2006) Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation. Exp Cell Res 312(15):2933-2941
    • (2006) Exp Cell Res , vol.312 , Issue.15 , pp. 2933-2941
    • Collesellia, D.1    Bijuklicb, K.2    Mosheimerb, B.A.3    Kählera, C.M.4
  • 55
    • 0342949550 scopus 로고    scopus 로고
    • Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword
    • Chen G, Wang S, Warner T (2000) Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword. Free Radic Res 32(3):223-234 (Pubitemid 30140165)
    • (2000) Free Radical Research , vol.32 , Issue.3 , pp. 223-234
    • Chen, G.1    Wang, S.H.2    Warner, T.D.3


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