Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells

Free Radical Research

Volumn 44, Issue 5, 2010, Pages 577-584

  Wang, Hong Jun ^a   Wei, Xiao Feng ^a   Jiang, Yuan Yuan ^a   Huang, Huai ^a   Yang, Ying ^a   Fan, Si Miao ^a   Zang, Ling He ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

*NO; ROS; Silibinin

Indexed keywords

CASPASE 8; FLAVONOLIGNAN; HYDROGEN PEROXIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SILIBININ; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CAENORHABDITIS ELEGANS; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER PROTECTION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; NITRIC OXIDE; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SILYMARIN; TIME FACTORS; TUMOR CELLS, CULTURED;

CAENORHABDITIS ELEGANS;

EID: 77951293065     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715761003692495     Document Type: Article

References (27)

1. Wellington K, Jarwis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 2001;15:465-489. (Pubitemid 32783707)
2. Wang HJ, Jiang YY, Wei XF, Huang H, Tashiro S, Onodera S, Ikejima T. Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells. Free Radic Res 2010;44:90-100.
3. Wang Y, Marsden PA. Nitric oxide synthases: gene structure and regulation. Adv Pharmacol 1995;34:71-90.
4. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996;271:C1424-C1437.
5. Wang HJ, Tashiro S, Onodera S, Ikejima T. Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochon-drial apoptotic pathways in human breast cancer MCF-7 cells. J Pharmacol Sci 2008;107:260-269. (Pubitemid 352030312)
6. Boveris A, Costa L, Cadenas E, Poderoso JJ. Regulation of mitochondrial respiration by adenosine phosphate, oxygen, and nitric oxide. Methods Enzymol 1999;301:188-198. (Pubitemid 30026830)
7. Radi R, Rodriguez M, Castro L, Telleri R. Inhibition of mito-chondrial electron transport by peroxynitrite. Arch Biochem Biophys 1994;308:89-95. (Pubitemid 24172608)
8. Schulze-Osthoff K, Bauer MK, Vogt M, Wesselborg S. Oxida-tive stress and signal transduction. Int J Vitam Nutr Res 1997;67:336-342
9. Floh é L, Brigelius-Floh é R, Saliou C, Traber MG, Packer L. Redox regulation of NF-kappa B activation. Free Radic Biol Med 1997;22:1115-1126. (Pubitemid 27084148)
10. Circu ML, Aw T Y. Reactive oxygen species, cellular redox systems and apoptosis. Free Radic Biol Med 2010;48:749-762.
11. Ma Q. Transcriptional responses to oxidative stress: pathological and toxicological implications. Pharmacol Ther 2010;125:376-393.
12. Groeger G, Quiney C, Cotter TG. Hydrogen peroxide as a cell-survival signaling molecule. Antioxid Redox Signal 2009;11:2655-2671.
13. Gupta A, Rosenberger SF, Bowden GT. Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 1999;20:2063-2073. (Pubitemid 29535306)
14. Sulston J, Hodgkin J. Methods. In: Wood WB, editor. The nematode caenorhabditis elegans. New York: Cold Spring Harbor Laboratory Press; 1988. pp. 587-606.
15. Garvey EP, Oplinger JA, Furfi ne ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997;272:4959-4963. (Pubitemid 27090046)
16. Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J 1991;5:98-103 (Pubitemid 21892842)
17. Szab ó C, Ischiropoulos H, Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007;6:662-680. (Pubitemid 47207751)
18. Packer MA, Porteous CM, Murphy MP. Mitochondrial superoxide production in the presence of nitric oxide leads to the formation of peroxynitrite. Biochem Mol Biol Int 1996;40:527-534.
19. Cabello CM, Bair WB 3rd, Wondrak GT. Experimental therapeutics: targeting the redox Achilles heel of cancer. Curr Opin Investig Drugs 2007;8:1022-1037.
20. Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009;8:579-591.
21. Dr ö ge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95. (Pubitemid 34654215)
22. Chuang CH, Huang CS, Hu ML. Vitamin E and rutin syn-ergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells. Chem Biol Interact 2010;183:434-441.
23. Lee JA, Song HY, Ju SM, Lee SJ, Kwon HJ, Eum WS, Jang SH, Choi SY, Park JS. Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells. Exp Mol Med 2009;41:629-637.
24. Jourd ' heuil D. Increased nitric oxide-dependent nitrosylation of 4,5-diaminofl uorescein by oxidants: implications for the measurement of intracellular nitric oxide. Free Radic Biol Med 2002;33:676-684.
25. Poderoso J, Carreras M, Lisdero C, Riobo N, Schopfer F, Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys 1996;328:85-92. (Pubitemid 26108173)
26. Poderoso JJ, Peralta J, Lisdero C, Carreras M, Radisic M, Schopfer F, Cadenas E, Boveris A. Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart. Am J Physiol 1998;274:C112-C119. (Pubitemid 28099350)
27. Cleeter MW, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AH. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. FEBS Lett 1994;345:50-54.