Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase Π

Investigational New Drugs

Volumn 29, Issue 6, 2011, Pages 1347-1359

  Chen, Wen Ying ^a   Hsieh, Yu An ^b   Tsai, Ching I ^b   Kang, Ya Fei ^a   Chang, Fang Rong ^b   Wu, Yang Chang ^b,c   Wu, Chin Chung ^b  

^a FOOYIN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apigenin; Breast cancer; Glutathione s transferase ; Mitogen activated protein kinases; Oxidative stress; Protoapigenone

Indexed keywords

ANTINEOPLASTIC AGENT; APIGENIN; CASPASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN BCL XL; PROTOAPIGENONE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CYCLOHEXANONE DERIVATIVE; FLAVONE DERIVATIVE; GLUTATHIONE; GSTP1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; BREAST TUMOR; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APIGENIN; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLOHEXANONES; FEMALE; FLAVONES; FLOW CYTOMETRY; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856062120     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9497-0     Document Type: Article

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