Recombinant protein expression in milk of livestock species

Methods in Molecular Biology

Volumn 824, Issue , 2012, Pages 629-641

  Bösze, Zsuzsanna ^a   Hiripi, László ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

Author keywords

Expression vectors; Milk; Posttranslational modifications; Purification; Recombinant proteins; Transgenic animals

Indexed keywords

BACTERIAL DNA; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BIOTECHNOLOGY; COMPARATIVE STUDY; GENE VECTOR; GENETICS; ISOLATION AND PURIFICATION; LIVESTOCK; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MICROINJECTION; MILK; PROMOTER REGION; SPECIES DIFFERENCE; TRANSGENE; TRANSGENIC ANIMAL; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOTECHNOLOGY; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CHROMOSOMES, ARTIFICIAL, YEAST; DNA, BACTERIAL; GENETIC VECTORS; LIVESTOCK; MICROINJECTIONS; MILK; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSGENES;

ANIMALIA; MAMMALIA;

EID: 84855928962     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-433-9_34     Document Type: Article

References (56)

1. Houdebine, L. M. (2009) Production of pharmaceutical proteins by transgenic animals. Compar Immunol. Microbiol Infect. Dis. 32, 107-121.
2. Fan, J., and Watanabe, T. (2003) Transgenic rabbits as therapeutic protein bioreactors and human disease models. Pharmacol. Therap. 99, 261-282. (Pubitemid 37311195)
3. Robl, J. M., Wang, Z., Kasinathan, P., et al., (2007) Transgenic animal production and animal biotechnology. Theriogenology 67, 127-133. (Pubitemid 44854154)
4. Sumer, H., Liu, J., Tat, P., et al., (2009) Somatic cell nuclear transfer: pros and cons, J. Stem Cells 4, 85-93.
5. Wall, R. J. (2001) Pronuclear microinjection, Cloning Stem Cells 3, 209-220. (Pubitemid 34123563)
6. van Veen, H. A., Geerts, M. E., van Berkel, P. H., et al., (2002) Analytical cation-exchange chromatography to assess the identity, purity, and N-terminal integrity of human lactoferrin, Anal. Biochem. 309, 60-66. (Pubitemid 35305790)
7. Koles, K., van Berkel, P. H., Pieper, F. R., et al.,(2004) N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits. Glycobiology 14, 51-64. (Pubitemid 38159408)
8. Jongen, S. P., Gerwig, G. J., Leefl ang, B. R., et al., (2007) N-glycans of recombinant human acid alpha-glucosidase expressed in the milk of transgenic rabbits. Glycobiology 17, 600-619. (Pubitemid 47062704)
9. Gil, G. C., Velander, W. H., and Van Cott, K. E. (2008) Analysis of the N-glycans of recombinant human Factor IX purifi ed from transgenic pig milk. Glycobiology 18, 526-539. (Pubitemid 351865833)
10. Fujiwara, Y., Miwa, M., Takahashi, R., et al., (1999) High-level expressing YAC vector for transgenic animal bioreactors. Molec. Reprod. Develop. 52, 414-420. (Pubitemid 29122267)
11. Fujiwara, Y., Takahashi, R. I., Miwa, M., et al., (1999) Analysis of control elements for position- independent expression of human alphalactalbumin YAC. Molec. Reprod. Develop. 54, 17-23. (Pubitemid 29374843)
12. Rival-Gervier, S., Viglietta, C., Maeder, C., et al., (2002) Position-independent and tissuespecifi c expression of porcine whey acidic protein gene from a bacterial artifi cial chromosome in transgenic mice. Molec. Reprod. Develop. 63, 161-167. (Pubitemid 34971375)
13. Yang, P., Wang, J., Gong, G., et al., (2008) Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for largescale production of functional human lactoferrin, PloS One 3, e3453.
14. Baranyi, M., Hiripi, L., Szabo, L., et al.,(2007) Isolation and some effects of functional, lowphenylalanine kappa-casein expressed in the milk of transgenic rabbits. J. Biotechnol. 128, 383-392. (Pubitemid 46091810)
15. Raju, T. S., Briggs, J. B., Borge, S. M., et al., (2000) Species-specifi c variation in glycosylation of IgG: evidence for the species-specifi c sialylation and branch-specifi c galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology 10, 477-486. (Pubitemid 30216089)
16. Edmunds, T., Van Patten, S. M., Pollock, J., et al., (1998) Transgenically produced human antithrombin: structural and functional comparison to human plasma-derived antithrombin, Blood 91, 4561-4571. (Pubitemid 28270304)
17. Montesino, R., Toledo, J. R., Sanchez, O., et al., (2008) Monosialylated biantennary N-glycoforms containing GalNAc-GlcNAc antennae predominate when human EPO is expressed in goat milk. Arch. Biochem. Biophys. 470, 163-175.
18. Maga, E. A., and Murray, J. D. (1995) Mammary gland expression of transgenes and the potential for altering the properties of milk, Biotechnology 13, 1452-1457. (Pubitemid 3006152)
19. Yen, C. H., Yang, C. K., Chen, I. C., et al., (2008) Expression of recombinant Hirudin in transgenic mice milk driven by the goat betacasein promoter. Biotechnol. J. 3, 1067-1077.
20. Lenasi, T., Kokalj-Vokac, N., Narat, M., et al., (2005) Functional study of the equine betacasein and kappa-casein gene promoters, J. Dairy Res. 72 Spec No, 34-43. (Pubitemid 41323093)
21. Bhure, S., and Sharma, B. (2007) Cloning and characterization of ovine alphaS1-casein gene promoter: A transfection study in rat mammary gland cell line. DNA Seq. 18, 39-46. (Pubitemid 46277061)
22. Lois, C., Hong, E. J., Pease, S., et al., (2002) Germline transmission and tissue-specifi c expression of transgenes delivered by lentiviral vectors. Science 295, 868-872. (Pubitemid 34118370)
23. Bijvoet, A. G., Van Hirtum, H., Kroos, M. A., et al., (1999) Human acid alpha-glucosidase from rabbit milk has therapeutic effect in mice with glycogen storage disease type II. Human Molec. Gen. 8, 2145-2153. (Pubitemid 29525328)
24. Hiripi, L., Baranyi, M., Szabo, L., et al., (2000) Effect of rabbit kappa-casein expression on the properties of milk from transgenic mice. J. Dairy Res. 67, 541-550. (Pubitemid 32122069)
25. Chung, J. H., Whiteley, M., and Felsenfeld, G. (1993) A 5 element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74, 505-514. (Pubitemid 23244616)
26. Filippova, G. N. (2008) Genetics and epigenetics of the multifunctional protein CTCF. Curr. Top. Develop. Biol. 80, 337-360.
27. West, A. G., Huang, S., Gaszner, M., et al., (2004) Recruitment of histone modifi cations by USF proteins at a vertebrate barrier element. Molec. Cell 16, 453-463. (Pubitemid 39504798)
28. Huang, S., Li, X., Yusufzai, T. M., et al., (2007) USF1 recruits histone modifi cation complexes and is critical for maintenance of a chromatin barrier, Molec. Cell. Biol. 27, 7991-8002. (Pubitemid 350086431)
29. Mutskov, V. J., Farrell, C. M., Wade, P. A., et al., (2002) The barrier function of an insulator couples high histone acetylation levels with specifi c protection of promoter DNA from methylation. Genes Develop. 16, 1540-1554. (Pubitemid 34686335)
30. Wang, Y., DeMayo, F. J., Tsai, S. Y., et al., (1997) Ligand-inducible and liver-specifi c target gene expression in transgenic mice. Nature Biotechnol. 15, 239-243. (Pubitemid 27118267)
31. Potts, W., Tucker, D., Wood, H., et al., (2000) Chicken beta-globin 5 HS4 insulators function to reduce variability in transgenic founder mice. Biochem. Biophys. Res. Comm. 273, 1015-1018. (Pubitemid 30481071)
32. Cremer, T., Kreth, G., Koester, H., et al., (2000) Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture. Crit. Rev. Eukaryiot. Gene Exp. 10, 179-212.
33. Phi-Van, L., and Stratling, W. H. (1996) Dissection of the ability of the chicken lysozyme gene 5 matrix attachment region to stimulate transgene expression and to dampen position effects. Biochemistry 35, 10735-10742. (Pubitemid 26279653)
34. Goetze, S., Baer, A., Winkelmann, S., et al., (2005) Performance of genomic bordering elements at predefi ned genomic loci. Molec. Cell. Biol. 25, 2260-2272. (Pubitemid 40354623)
35. Evans, K., Ott, S., Hansen, A., et al., (2007) A comparative study of S/MAR prediction tools, BMC Bioinformatics 8, 71.
36. Lunyak, V. V., Prefontaine, G. G., Nunez, E., et al., (2007) Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis, Science 317, 248-251. (Pubitemid 47076201)
37. Willoughby, D. A., Vilalta, A., and Oshima, R. G. (2000) An Alu element from the K18 gene confers position-independent expression in transgenic mice, The J. Biol.Chem. 275, 759-768. (Pubitemid 30051113)
38. Li, Q., Peterson, K. R., Fang, X., et al., (2002) Locus control regions, Blood 100, 3077-3086. (Pubitemid 35217052)
39. Grosveld, F., van Assendelft, G. B., Greaves, D. R., et al., (1987) Position-independent, highlevel expression of the human beta-globin gene in transgenic mice. Cell 51, 975-985.
40. Bessa, J., Tena, J. J., de la Calle-Mustienes, E., et al., (2009) Zebrafi sh enhancer detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafi sh, Dev. Dyn. 238, 2409-2417.
41. Montoliu, L., Roy, R., Regales, L., et al., (2009) Design of vectors for transgene expression: The use of genomic comparative approaches, Comp. Immunol. Microbiol. Infect. Dis. 32, 81-90.
42. Woolfe, A., Goodson, M., Goode, D. K., et al., (2005) Highly conserved non-coding sequences are associated with vertebrate development, PLoS Biology 3, e7.
43. de la Calle-Mustienes, E., Feijoo, C. G., Manzanares, M., et al., (2005) A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts. Genome Res. 15, 1061-1072. (Pubitemid 41126861)
44. Gerencser, A., Barta, E., Boa, S., et al., (2002) Comparative analysis on the structural features of the 5 fl anking region of kappa-casein genes from six different species. Genet. Sel. Evol. 34, 117-128. (Pubitemid 34456330)
45. Yang, X. W., Model, P., and Heintz, N. (1997) Homologous recombination based modifi cation in Escherichia coli and germline transmission in transgenic mice of a bacterial artifi cial chromosome, Nature Biotechnol. 15, 859-865.
46. Sparwasser, T., Gong, S., Li, J. Y., et al., (2004) General method for the modifi cation of different BAC types and the rapid generation of BAC transgenic mice, Genesis 38, 39-50. (Pubitemid 38197608)
47. Muyrers J P., Zhang, Y., Testa, G., et al., (1999) Rapid modifi cation of bacterial artifi cial chromosomes by ET-recombination. Nucl. Acids Res. 27, 1555-1557. (Pubitemid 29206301)
48. Van Keuren, M. L., Gavrilina, G. B., Filipiak, W. E., et al., (2009) Generating transgenic mice from bacterial artifi cial chromosomes: transgenesis effi ciency, integration and expression outcomes. Transgenic Res. 18, 769-785.
49. DiTullio, P., Cheng, S. H., Marshall, J., et al., (1992) Production of cystic fi brosis transmembrane conductance regulator in the milk of transgenic mice. Bio/technology 10, 74-77.
50. Bodrogi, L., Brands, R., Raaben, W., et al., (2006) High level expression of tissue-nonspecifi c alkaline phosphatase in the milk of transgenic rabbits. Transgenic Res. 15, 627-636. (Pubitemid 44401442)
51. Ahn, Y. S., and Snow, L. D. (1993) Selective extraction of alkaline phosphatase and 5 - nucleotidase from milk fat globule membranes by a single phase n-butanol procedure. Prep. Biochem. 23, 409-419.
52. Baldassarre, H., Hockley, D. K., Dore, M., et al., (2008) Lactation performance of transgenic goats expressing recombinant human butyryl-cholinesterase in the milk. Transgenic Res. 17, 73-84.
53. Van Cott, K. E., Lubon, H., Russell, C. G., et al., (1997) Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C. Transgenic Res. 6, 203-212. (Pubitemid 27218644)
54. Hiripi, L., Makovics, F., Halter, R., et al., (2003) Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits. DNA Cell Biol. 22, 41-45. (Pubitemid 36570517)
55. Al-Ghobashy, M. A., Williams, M. A., Brophy, B., et al., (2009) On-line casein micelle disruption for downstream purifi cation of recombinant human myelin basic protein produced in the milk of transgenic cows. J. Chromat. 877, 1667-1677.
56. Wang, J., Yang, P., Tang, B., et al., (2008) Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows. J. Dairy Sci. 91, 4466-4476. (Pubitemid 352847736)