Isolation and some effects of functional, low-phenylalanine κ-casein expressed in the milk of transgenic rabbits

Journal of Biotechnology

Volumn 128, Issue 2, 2007, Pages 383-392

  Baranyi, Mária ^a   Hiripi, László ^a   Szabó, László ^a   Catunda, Ana Paula ^a   Harsányi, Ibolya ^a   Komáromy, Péter ^b   Bosze, Zsuzsanna ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

^b Institute of Isotopes   (Hungary)

Author keywords

Altered milk composition; Casein micelle size; Low phenylalanine casein; Phenylketonuria; Transgenic rabbit

Indexed keywords

DISEASES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MICELLES; MUTAGENESIS; PROTEINS;

ALTERED MILK COMPOSITIONS; CASEIN MICELLE SIZE; PHENYLKETONURIA; TRANSGENIC RABBITS;

NITROGEN COMPOUNDS;

CHYMOSIN; KAPPA CASEIN; MILK PROTEIN; OLIGONUCLEOTIDE; PHENYLALANINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE CONSTRUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICELLE; MILK; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; RABBIT; SITE DIRECTED MUTAGENESIS; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CASEINS; FEMALE; MICELLES; MILK; PHENYLALANINE; RABBITS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33846206753     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2006.10.016     Document Type: Article

References (21)

1. Baranyi M., Aszodi A., Devinoy E., Fontaine M.L., Houdebine L.M., and Bosze Z. Structure of the rabbit kappa-casein encoding gene: expression of the cloned gene in the mammary gland of transgenic mice. Gene 174 (1996) 27-34
2. Baranyi M., Brignon G., Anglade P., and Ribadeau-Dumas B. New data on the proteins of rabbit (Oryctolagus cuniculus) milk. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 111 (1995) 407-415
3. Bleck G.T., Jimenez-Flores R., and Bremel R.D. Abnormal properties of milk from transgenic mice expressing bovine β-casein under control of the bovine α-lactalbumin 5′ flanking region. Int. Dairy J. 5 (1995) 619-632
4. Bo{combining double acute accent}sze Zs., Hiripi L., Carnwath J.W., and Niemann H. The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins. Transgen. Res. 12 (2003) 541-553
5. Brignon G., Chtourou A., and Ribadeau-Dumas B. Preparation and amino acid sequence of human kappa-casein. FEBS Lett. 188 (1985) 48-54
6. Brophy B., Smolenski G., Wheeler T., Wells D., L'Huillier P., and Laible G. Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein. Nat. Biotechnol. 21 (2003) 157-162
7. Darling P.B., Dunn M., Gilani G.S., Ball R.O., and Pencharz P.B. Phenylalanine kinetics differ between formula-fed and human milk-fed preterm infants. J. Nutr. 134 (2004) 2540-2545
8. Devinoy E., Montoliu L., Baranyi M., Thepot D., Hiripi L., Fontaine M.L., Bodrogi L., and Bosze Z. Analysis of the efficiency of the rabbit whey acidic protein gene 5′ flanking region in controlling the expression of homologous and heterologous linked genes. J. Dairy Res. (2005) 113-119 72 Spec No
9. Dewan R.K., Bloomfield V.A., Chudgar A., and Morr C.V. Viscosity and voluminosity of bovine milk casein micelles. J. Dairy Sci. 56 (1973) 699-705
10. Ekstrand B., Larsson-Raznikiewicz M., and Perlmann C. Casein micelle size and composition related to the enzymatic coagulation process. Biochim. Biophys. Acta 630 (1980) 361-366
11. Fu Y.M., Yu Z.X., Ferrans V.J., and Meadows G.G. Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo. Nutr. Cancer 29 (1997) 104-113
12. Gutierrez-Adan A., Maga E.A., Meade H., Shoemaker C.F., Medrano J.F., Anderson G.B., and Murray J.D. Alterations of the physical characteristics of milk from transgenic mice producing bovine kappa-casein. J. Dairy Sci. 79 (1996) 791-799
13. Harvie M.N., Campbell I.T., Howell A., and Thatcher N. Acceptability and tolerance of a low tyrosine and phenylalanine diet in patients with advanced cancer-a pilot study. J. Hum. Nutr. Diet. 15 (2002) 193-202
14. Hiripi L., Baranyi M., Szabo L., Toth S., Fontaine M.L., Devinoy E., and Bosze Z. Effect of rabbit kappa-casein expression on the properties of milk from transgenic mice. J. Dairy Res. 67 (2000) 541-550
15. Jaubert A., and Martin P. Reverse-phase HPLC analysis of goat caseins. Identification of αS1 and αS2 genetic variants. Lait 72 (1992) 235-247
16. Lorincz A.B., Kuttner R.E., and Brandt M.B. Tumor response to phenylalanine-tyrosine-limited diets. J. Am. Diet. Assoc. 54 (1969) 198-205
17. Meadows G.G., Pierson H.F., Abdallah R.M., and Desai P.R. Dietary influence of tyrosine and phenylalanine on the response of B16 melanoma to carbidopa-levodopa methyl ester chemotherapy. Cancer Res. 42 (1982) 3056-3063
18. Pine M.J. Effect of low phenylalanine diet on murine leukemia L1210. J. Natl. Cancer Inst. 60 (1978) 633-641
19. Sullivan R.A., Fitzpatrick M.M., and Stanton E.K. Distribution of kappa casein in skim milk. Nature 183 (1959) 616-617
20. Visser S., Slangen C.J., and Rollema H.S. Phenotyping of bovine milk proteins by reversed-phase high-performance liquid chromatography. J. Chromatogr. 548 (1991) 361-370
21. Visser S., Van Rooijen P.J., Schattenkerk C., and Kerling K.E. Peptide substrates for chymosin (rennin). Kinetic studies with bovine kappa-casein-(103-108)-hexapeptide analogues. Biochim. Biophys. Acta 481 (1977) 171-176