Lactation performance of transgenic goats expressing recombinant human butyryl-cholinesterase in the milk

Transgenic Research

Volumn 17, Issue 1, 2008, Pages 73-84

  Baldassarre, Hernan ^a,c   Hockley, Duncan K ^a   Doré, Monique ^b   Brochu, Eric ^a   Hakier, Bernard ^a   Zhao, Xin ^c   Bordignon, Vilceu ^c  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Cholinesterase; Goat; Lactation; Lipid secretion; Transgenic

Indexed keywords

CHOLINESTERASE; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETICS; GOAT; HISTOLOGY; HUMAN; LACTATION; MILK; PATHOLOGY; PHYSIOLOGY; PREGNANCY; TRANSGENIC ANIMAL; UDDER;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BUTYRYLCHOLINESTERASE; FEMALE; GENE EXPRESSION; GOATS; HUMANS; LACTATION; MAMMARY GLANDS, ANIMAL; MILK; PREGNANCY; RECOMBINANT PROTEINS;

ANIMALIA; CAPRA HIRCUS;

EID: 37549043956     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-007-9137-4     Document Type: Article

References (43)

1. Baldassarre H, Karatzas CN (2004) Advanced assisted reproduction technologies (ART) in goats. Anim Reprod Sci 82-83:255-266
2. Baldassarre H, Wang B, Keefer CL, Lazaris A, Karatzas CN (2004) State of the art in the production of transgenic goats. Reprod Fertil Dev 16:465-470
3. Behboodi E, Ayres SL, Memili E, O'Coin M, Chen LH, Reggio BC, Landry AM, Gavin WG, Meade HM, Godke RA, Echelard Y (2005) Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer. Cloning Stem Cells 7:107-118
4. Bodrogi L, Brands R, Raaben W, Seinen W, Baranyi M, Fiechter D, Bosze Z (2006) High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits. Transgenic Res 15:627-636
5. Brophy B, Smolenski G, Wheeler T, Wells D, L'Huillier P, Laible G (2003) Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein. Nat Biotechnol 21:157-162
6. Capuco AV, Akers RM (1999) Mammary involution in dairy animals. J Mammary Gland Biol Neoplasia 4:137-144
7. Cerasoli DM, Griffiths EM, Doctor, BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE (2005) In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact 157-158:363-365
8. Denman J, Hayes M, O'Day C, Edmunds T, Bartlett C, Hirani S, Ebert KM, Gordon K, McPherson JM (1991) Transgenic expression of a variant of human tissue-type plasminogen activator in goat milk: purification and characterization of the recombinant enzyme. Biotechnology (NY) 9:839-843
9. Doctor, BP, Saxena A (2005) Bioscavengers for the protection of humans against organophosphate toxicity. Chem Biol Interact 157-158:167-171
10. Ebert KM, DiTullio P, Barry CA, Schindler JE, Ayres SL, Smith TE, Pellerin LJ, Meade HM, Denman J, Roberts B (1994) Induction of human tissue plasminogen activator in the mammary gland of transgenic goats. Biotechnology (N Y ) 12:699-702
11. Echelard Y, Destrempes MM, Koster JA, Blackwell C, Groen W, Pollock D, Williams JL, Behboodi E, Pommer J, Meade HM (2002) Production of recombinant human serum albumin in the milk of transgenic cows. Theriogenology 57:779
12. Eichner W, Sommermeyer K (1999) Large scale production of RH-albumin expressed in the milk of transgenic cattle-an economic and technical challenge. Anasthesiol Intensivmed Notfallmed Schmerzther 34:777-778
13. Ellman GC, Courtney KP, Andres V Jr, Featherstone RM (1961) A new rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95
14. Evans G, Maxwell WM (1987) Salamon's artificial insemination of sheep and goats. Butterworths, Sydney, Australia
15. Houdebine LM (2000) Transgenic animal bioreactors. Transgenic Res 9:305-320
16. Hyvonen P, Suojala L, Haaranen J, von, WA, Pyorala S (2006) Human and bovine lactoferrins in the milk of recombinant human lactoferrin-transgenic dairy cows during lactation. Biotechnol J 1:410-412
17. Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Cote M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemee N, Wilgus H, Begin I, Bhatia B, Rao K, Neveu N, Brochu E, Pierson J, Hockley DK, Cerasoli DM, Lenz, DE, Karatzas CN, Langermann S (2007) Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci USA 104:13603 - 13608
18. Jones ML (2002) Lipids. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques. Churchill Livingston, Philadelphia, pp 201-230
19. Karatzas CN, Zhou FJ, Huang Y, Duguay F, Chretien N, Bhatia B, Bilodeau AS, Keyston R, Tao T, Keefer CL, Wang B, Baldassarre H, Lazaris A (1999) Production of recombinant spider silk (BioSteel®) in the milk of transgenic animals. Transgenic Res 8:476-477
20. Keefer CL (2004) Production of bioproducts through the use of transgenic animal models. Anim Reprod Sci 82-83:5-12
21. Ko JH, Lee CS, Kim KH, Pang MG, Koo JS, Fang N, Koo DB, Oh KB, Youn WS, Zheng GD, Park JS, Kim SJ, Han YM, Choi IY, Lim J, Shin ST, Jin SW, Lee KK, Yoo OJ (2000) Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat. Transgenic Res 9:215-222
22. Maga EA, Shoemaker CF, Rowe JD, Bondurant RH, Anderson GB, Murray JD (2006) Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland. J Dairy Sci 89:518-524
23. Mather IH, Keenan TW (1998) Origin and secretion of milk lipids. J Mammary Gland Biol Neoplasia 3:259-273
24. Niemann H, Halter R, Carnwath JW, Herrmann D, Lemme E, Paul D (1999) Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep. Transgenic Res 8:237-247
25. Ogg SL, Weldon AK, Dobbie L, Smith AJ, Mather IH (2004) Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A 101:10084-10089
26. Palmer CA, Lubon H, McManaman JL (2003) Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development. Transgenic Res 12:283-292
27. Parker MH, Birck-Wilson E, Allard G, Masiello N, Day M, Murphy KP, Paragas V, Silver S, Moody MD (2004) Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goats. Protein Expr Purif 38:177-183
28. Pollock DP, Kutzko JP, Birck-Wilson E, Williams JL, Echelard Y, Meade HM (1999) Transgenic milk as a method for the production of recombinant antibodies. J Immunol Methods 231:147-157
29. Prunkard D, Cottingham I, Garner I, Bruce S, Dalrymple M, Lasser G, Bishop P, Foster D (1996) High-level expression of recombinant human fibrinogen in the milk of transgenic mice. Nat Biotechnol 14:867-871
30. Pursel VG, Wall RJ, Solomon MB, Bolt DJ, Murray JE, Ward KA (1997) Transfer of an ovine metallothionein-ovine growth hormone fusion gene into swine. J Anim Sci 75:2208-2214
31. Rainard P (2003) The complement in milk and defense of the bovine mammary gland against infections. Vet Res 34:647-670
32. Salamone D, Baranao L, Santos C, Bussmann L, Artuso J, Werning C, Prync A, Carbonetto C, Dabsys S, Munar C, Salaberry R, Berra G, Berra I, Fernandez N, Papouchado M, Foti M, Judewicz N, Mujica I, Munoz L, Alvarez SF, Gonzalez E, Zimmermann J, Criscuolo M, Melo C (2006) High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow. J Biotechnol 124:469-472
33. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, New York
34. Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, Wilmut I, Colman A, Campbell KH (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278:2130-2133
35. Vorbach C, Scriven A, Capecchi MR (2002) The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev 16:3223-3235
36. Wall RJ, Kerr DE, Bondioli KR (1997) Transgenic dairy cattle: genetic engineering on a large scale. J Dairy Sci 80:2213-2224
37. Wall RJ, Powell AM, Paape MJ, Kerr DE, Bannerman DD, Pursel VG, Wells KD, Talbot N, Hawk HW (2005) Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nat Biotechnol 23:445-451
38. Weng MH, Chang CJ, Chen WY, Chou WK, Peh HC, Huang MC, Chen MT, Nagahata H (2006) Contribution of somatic cell-associated activation of plasminogen to caseinolysis within the goat mammary gland. J Dairy Sci 89:2025-2037
39. Wheeler MB (2003) Production of transgenic livestock: promise fulfilled. J Anim Sci 81(Suppl 3):32-37
40. Wheeler MB, Walters EM, Clark SG (2003) Transgenic animals in biomedicine and agriculture: outlook for the future. Anim Reprod Sci 79:265-289
41. Young MW, Meade H, Curling JM, Ziomek CA, Harvey M (1998) Production of recombinant antibodies in the milk of transgenic animals. Res Immunol 149:609-610
42. Zhang RH, Mustafa AF, Ng-Kwai-Hang KF, Zhao X (2006) Effects of freezing on composition and fatty acid profiles of sheep milk and cheese. Small Ruminant Research 64:203-210
43. Zhou Q, Kyazike J, Echelard Y, Meade HM, Higgins E, Cole ES, Edmunds T (2005) Effect of genetic background on glycosylation heterogeneity in human antithrombin produced in the mammary gland of transgenic goats. J Biotechnol 117:57-72