Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: Activation of c-Jun NH2-terminal kinase and promoter response element

Blood

Volumn 96, Issue 6, 2000, Pages 2140-2148

  Cai, Y ^a   Zhang, C ^a   Nawa, T ^a   Aso, T ^a   Tanaka, M ^a   Oshiro, S ^a   Ichijo, H ^a   Kitajima, S ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DITHIOTHREITOL; HOMOCYSTEINE; MERCAPTOETHANOL; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TUNICAMYCIN;

ARTICLE; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; HOMOCYSTINURIA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 0034665653     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2140.h8002140_2140_2148     Document Type: Article

References (55)

1. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
2. Homocysteinuria
3. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy
4. Homocysteine and vascular disease
5. Homocysteine and atherothrombosis
6. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
7. Activation of endogenous factor V by homocysteine-induced vascular endothelial cell activator
8. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
9. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
10. Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum
11. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
12. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
13. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
14. Promotion of vascular smooth muscle cell growth by homocysteine A link to atherosclerosis
15. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells
16. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes
17. Characterization of the stress-inducing effects of homocysteine
18. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human endothelial cells
19. Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA
20. Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
21. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
22. CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
23. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
24. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A
25. Activating transcription factor-1 can mediate Ca (2+)- and cAMP-inducible transcriptional activation
26. ATF3 and ATF3 delta Zip: Transcriptional repression versus activation by alternatively spliced isoforms
27. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10
28. Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver
29. Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to E1A-dependent induction of ATF3
30. Protein measurement with folin phenol reagent
31. ATF3 gene: Genomic organization, promoter, and regulation
32. Characterization of the promoter for the human P-selectin gene
33. Structure and cell cycle-regulated transcription of the human cyclin A gene
34. The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells
35. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
36. Heterodimer formation of c-Jun and ATF-2 is responsible for induction of c-Jun by the 243 amino acid adenovirus E1A protein
37. Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
38. Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4
39. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
40. Transcription factor ATF2 regulation by the JNK signal transduction pathway
41. 2-terminal kinases target the ubiquitination of their associated transcription factors
42. Stress-activated kinases regulate protein stability
43. Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-κB and c-Jun N-terminal kinase/p38 mitogen-activated protein kinase pathways
44. Complexes containing activating transcription factor (ATF)/cAMP-responsive element binding protein (CREB) interact with the CCAAT/enhancer binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
45. Differential regulation of mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7) by signaling from G protein βγ, subunit in human embryonal kidney 293 cells
46. The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
47. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
48. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
49. Inhibition of growth and p21(ras) methylation in vascular endothelial cells by homocysteine but not cysteine
50. Selective killing induced by an inhibitor of N-linked glycosylation
51. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
52. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ, radiation-induced apoptosis
53. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ, radiation: Duration of JNK activation may determine cell death and proliferation
54. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells
55. Endothelial cell dysfunction in homocystinuria