Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: Implications for fluperlapine-induced agranulocytosis

Drug Metabolism and Disposition

Volumn 28, Issue 3, 2000, Pages 255-263

  George Lai, W ^a   Gardner, Iain ^a   Zahid, Nasir ^a   Uetrecht, Jack P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYFLUPERLAPINE; ACETYLCYSTEINE; ANTIBODY; CLOZAPINE; DRUG METABOLITE; FLUPERLAPINE; GLUTATHIONE; MIANSERIN; PROCAINAMIDE; UNCLASSIFIED DRUG;

AGRANULOCYTOSIS; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; ENZYME MODIFICATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NEUTROPHIL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ACETYLCYSTEINE; AGRANULOCYTOSIS; BINDING, COMPETITIVE; CLOZAPINE; DIBENZAZEPINES; GLUTATHIONE; HEMOCYANIN; HUMANS; HYPOCHLOROUS ACID; IMMUNE SERA; IMMUNOBLOTTING; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; PROTEIN BINDING;

EID: 20644465609     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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