Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 367-377

  Reddy, P V Narasimha ^a   Jensen, Katherine C ^b   Mesecar, Andrew D ^b   Fanwick, Phillip E ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,8 DICHLORO 1 METHYL 2 OXO 1,2 DIHYDROPYRROLO[4,3,2 D,E]QUINOLINE 4 CARBOXAMIDE; 6,8 DICHLORO N,N,1 TRIMETHYL 2 OXO 1,2 DIHYDROPYRROLO[4,3,2 D,E]QUINOLINE 4 CARBOXAMIDE; 7 AMINO 6 IODO 4 METHOXYCARBONYLQUINOLINE 2 CARBOXAMIDE; 7 AMINO 6 IODOQUINOLINE 2,4 DICARBOXAMIDE; AMMOSAMIDE B; ANTINEOPLASTIC AGENT; DIMETHYL 5 AMINO 6,8 DICHLOROQUINOLINE 2,4 DICARBOXYLATE; DIMETHYL 5 CHLORO 7 (DIMETHYLAMINO)QUINOLINE 2,4 DICARBOXYLATE; DIMETHYL 6,7 DIAMINO 5 CHLOROQUINOLINE 2,4 DICARBOXYLATE; DIMETHYL 7 ACETAMIDO 5 CHLOROQUINOLINE 2,4 DICARBOXYLATE; DIMETHYL 7 AMINO 5 CHLOROQUINOLINE 2,4 DICARBOXYLATE; DIMETHYL 7 AMINO 5,8 DICHLOROQUINOLINE 2,4 DICARBOXYLATE; METHYL 2 CARBAMOYL 5 CHLORO 7 (DIMETHYLAMINO)QUINOLINE 4 CARBOXYLATE; METHYL 6,7 DIAMINO 2 CARBAMOYL 5 CHLOROQUINOLINE 4 CARBOXYLATE; METHYL 6,8 DICHLORO 1 METHYL 7 NITRO 2 OXO 1,2 DIHYDROPYRROLO[4,3,2 D,E]QUINOLINE 4 CARBOXYLATE; METHYL 7 ACETAMIDO 2 CARBAMOYL 5 CHLOROQUINOLINE 4 CARBOXYLATE; METHYL 7 AMINO 2 CARBAMOYL 5 CHLOROQUINOLINE 4 CARBOXYLATE; N BENZYL 6,8 DICHLORO 1 METHYL 2 OXO 1,2 DIHYDROPYRROLO[4,3,2 D,E]QUINOLINE 4 CARBOXAMIDE; PYRROLOQUINOLINEQUINONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HCT116; CELL STRAIN MCF 7; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; METHYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; STEADY STATE;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLES; QUINOLINES; QUINONE REDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855853375     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201251c     Document Type: Article

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