-
1
-
-
0000665443
-
Enzymatic oxidation of some nonphosphorylated derivatives of dihydronicotinamide
-
S. Liao, and H.G. Williams-Ashmau Enzymatic oxidation of some nonphosphorylated derivatives of dihydronicotinamide Biochem. Biophys. Res. Commun. 4 1961 208 213
-
(1961)
Biochem. Biophys. Res. Commun.
, vol.4
, pp. 208-213
-
-
Liao, S.1
Williams-Ashmau, H.G.2
-
2
-
-
0033520090
-
Crystal structure of human quinone reductase type 2, a metalloflavoprotein
-
C.E. Foster, M.A. Bianchet, P. Talalay, Q. Zhao, and L.M. Amzel Crystal structure of human quinone reductase type 2, a metalloflavoprotein Biochemistry 38 1999 9881 9886
-
(1999)
Biochemistry
, vol.38
, pp. 9881-9886
-
-
Foster, C.E.1
Bianchet, M.A.2
Talalay, P.3
Zhao, Q.4
Amzel, L.M.5
-
3
-
-
0025018844
-
Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6
-
A.K. Jaiswal, P. Burnett, M. Adesnik, and O.W. McBride Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6 Biochemistry 29 1990 1899 1906
-
(1990)
Biochemistry
, vol.29
, pp. 1899-1906
-
-
Jaiswal, A.K.1
Burnett, P.2
Adesnik, M.3
McBride, O.W.4
-
4
-
-
0035834571
-
An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: Glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
-
S. Harada, C. Fujii, A. Hayashi, and N. Ohkoshi An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2 Biochem. Biophys. Res. Commun. 288 2001 887 892
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.288
, pp. 887-892
-
-
Harada, S.1
Fujii, C.2
Hayashi, A.3
Ohkoshi, N.4
-
5
-
-
0347592777
-
A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia
-
S. Harada, H. Tachikawa, and Y. Kawanishi A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia Psychiatr. Genet. 13 2003 205 209
-
(2003)
Psychiatr. Genet.
, vol.13
, pp. 205-209
-
-
Harada, S.1
Tachikawa, H.2
Kawanishi, Y.3
-
6
-
-
0043165082
-
Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms
-
T. Okubo, S. Harada, S. Higuchi, and S. Matsushita Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms Alcohol Clin. Exp. Res. 27 2003 68S 71S
-
(2003)
Alcohol Clin. Exp. Res.
, vol.27
-
-
Okubo, T.1
Harada, S.2
Higuchi, S.3
Matsushita, S.4
-
7
-
-
0345688810
-
NQO2 gene is associated with clozapine-induced agranulocytosis
-
O. Ostrousky, S. Meged, R. Loewenthal, A. Valevski, A. Weizman, H. Carp, and E. Gazit NQO2 gene is associated with clozapine-induced agranulocytosis Tissue Antigens 62 2003 483 491
-
(2003)
Tissue Antigens
, vol.62
, pp. 483-491
-
-
Ostrousky, O.1
Meged, S.2
Loewenthal, R.3
Valevski, A.4
Weizman, A.5
Carp, H.6
Gazit, E.7
-
8
-
-
0033805326
-
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
-
A.T. Dinkova-Kostova, and P. Talalay Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen Free Radic. Biol. Med. 29 2000 231 240
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 231-240
-
-
Dinkova-Kostova, A.T.1
Talalay, P.2
-
9
-
-
0033805383
-
Structure-function studies of DT-diaphorase (NQO1) and NRH: Quinone oxidoreductase (NQO2)
-
S. Chen, K. Wu, and R. Knox Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2) Free Radic. Biol. Med. 29 2000 276 284
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 276-284
-
-
Chen, S.1
Wu, K.2
Knox, R.3
-
10
-
-
0033800872
-
Structures of mammalian cytosolic quinone reductases
-
C.E. Foster, M.A. Bianchet, P. Talalay, M. Faig, and L.M. Amzel Structures of mammalian cytosolic quinone reductases Free Radic. Biol. Med. 29 2000 241 245
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 241-245
-
-
Foster, C.E.1
Bianchet, M.A.2
Talalay, P.3
Faig, M.4
Amzel, L.M.5
-
11
-
-
0033871181
-
Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: A novel co-substrate-mediated antitumor prodrug therapy
-
R.J. Knox, T.C. Jenkins, S.M. Hobbs, S. Chen, R.G. Melton, and P.J. Burke Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy Cancer Res. 60 2000 4179 4186
-
(2000)
Cancer Res.
, vol.60
, pp. 4179-4186
-
-
Knox, R.J.1
Jenkins, T.C.2
Hobbs, S.M.3
Chen, S.4
Melton, R.G.5
Burke, P.J.6
-
12
-
-
12644302182
-
Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
-
Q. Zhao, X.L. Yang, W.D. Holtzclaw, and P. Talalay Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) Proc. Natl. Acad. Sci. USA 94 1997 1669 1674
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1669-1674
-
-
Zhao, Q.1
Yang, X.L.2
Holtzclaw, W.D.3
Talalay, P.4
-
13
-
-
4444267291
-
Crystal structure of quinone reductase 2 in complex with resveratrol
-
L. Buryanovskyy, Y. Fu, M. Boyd, Y. Ma, T.C. Hsieh, J.M. Wu, and Z. Zhang Crystal structure of quinone reductase 2 in complex with resveratrol Biochemistry 43 2004 11417 11426
-
(2004)
Biochemistry
, vol.43
, pp. 11417-11426
-
-
Buryanovskyy, L.1
Fu, Y.2
Boyd, M.3
Ma, Y.4
Hsieh, T.C.5
Wu, J.M.6
Zhang, Z.7
-
14
-
-
0036605993
-
Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia
-
D.J. Long 2nd, A. Gaikwad, A. Multani, S. Pathak, C.A. Montgomery, F.J. Gonzalez, and A.K. Jaiswal Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia Cancer Res. 62 2002 3030 3036
-
(2002)
Cancer Res.
, vol.62
, pp. 3030-3036
-
-
Long II, D.J.1
Gaikwad, A.2
Multani, A.3
Pathak, S.4
Montgomery, C.A.5
Gonzalez, F.J.6
Jaiswal, A.K.7
-
15
-
-
0037195924
-
Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity
-
D.J. Long 2nd, K. Iskander, A. Gaikwad, M. Arin, D.R. Roop, R. Knox, R. Barrios, and A.K. Jaiswal Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity J. Biol. Chem. 277 2002 46131 46139
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 46131-46139
-
-
Long II, D.J.1
Iskander, K.2
Gaikwad, A.3
Arin, M.4
Roop, D.R.5
Knox, R.6
Barrios, R.7
Jaiswal, A.K.8
-
16
-
-
0036015563
-
Nitroreductase-based GDEPT
-
W.A. Denny Nitroreductase-based GDEPT Curr. Pharm. Des. 8 2002 1349 1361
-
(2002)
Curr. Pharm. Des.
, vol.8
, pp. 1349-1361
-
-
Denny, W.A.1
-
17
-
-
0027182862
-
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
-
R.J. Knox, F. Friedlos, and M.P. Boland The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT) Cancer Metastasis Rev. 12 1993 195 212
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 195-212
-
-
Knox, R.J.1
Friedlos, F.2
Boland, M.P.3
-
18
-
-
0034814342
-
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A phase I and pharmacokinetic study of its prodrug, CB1954
-
G. Chung-Faye, D. Palmer, D. Anderson, J. Clark, M. Downes, J. Baddeley, S. Hussain, P.I. Murray, P. Searle, L. Seymour, P.A. Harris, D. Ferry, and D.J. Kerr Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954 Clin. Cancer Res. 7 2001 2662 2668
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2662-2668
-
-
Chung-Faye, G.1
Palmer, D.2
Anderson, D.3
Clark, J.4
Downes, M.5
Baddeley, J.6
Hussain, S.7
Murray, P.I.8
Searle, P.9
Seymour, L.10
Harris, P.A.11
Ferry, D.12
Kerr, D.J.13
-
19
-
-
0024205344
-
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
-
R.J. Knox, M.P. Boland, F. Friedlos, B. Coles, C. Southan, and J.J. Roberts The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) Biochem. Pharmacol. 37 1988 4671 4677
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 4671-4677
-
-
Knox, R.J.1
Boland, M.P.2
Friedlos, F.3
Coles, B.4
Southan, C.5
Roberts, J.J.6
-
20
-
-
4544327822
-
Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography
-
Z. Wang, T.C. Hsieh, Z. Zhang, Y. Ma, and J.M. Wu Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography Biochem. Biophys. Res. Commun. 323 2004 743 749
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.323
, pp. 743-749
-
-
Wang, Z.1
Hsieh, T.C.2
Zhang, Z.3
Ma, Y.4
Wu, J.M.5
-
21
-
-
0031059866
-
-
J.R.M.S.C.W. Carter Academic Press New York
-
Z. Otwinowski, and W. Minor J.R.M.S.C.W. Carter Methods in Enzymology 1997 Academic Press New York 307 326
-
(1997)
Methods in Enzymology
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
22
-
-
3543012707
-
Crystallography & NMR system: A new software suite for macromolecular structure determination
-
A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.S. Jiang, J. Kuszewski, M. Nilges, N.S. Pannu, R.J. Read, L.M. Rice, T. Simonson, and G.L. Warren Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr. D 54 Pt 5 1998 905 921
-
(1998)
Acta Crystallogr. D
, vol.54
, Issue.5 PART
, pp. 905-921
-
-
Brunger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
Read, R.J.11
Rice, L.M.12
Simonson, T.13
Warren, G.L.14
-
23
-
-
0031473847
-
SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
-
N. Guex, and M.C. Peitsch SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling Electrophoresis 18 1997 2714 2723
-
(1997)
Electrophoresis
, vol.18
, pp. 2714-2723
-
-
Guex, N.1
Peitsch, M.C.2
-
24
-
-
0034903751
-
Molray-a web interface between O and the POV-Ray ray tracer
-
M. Harris, and T.A. Jones Molray-a web interface between O and the POV-Ray ray tracer Acta Crystallogr. D 57 2001 1201 1203
-
(2001)
Acta Crystallogr. D
, vol.57
, pp. 1201-1203
-
-
Harris, M.1
Jones, T.A.2
-
25
-
-
0026075733
-
Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species
-
R.J. Knox, F. Friedlos, T. Marchbank, and J.J. Roberts Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species Biochem. Pharmacol. 42 1991 1691 1697
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 1691-1697
-
-
Knox, R.J.1
Friedlos, F.2
Marchbank, T.3
Roberts, J.J.4
-
26
-
-
0031573462
-
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase
-
K. Wu, R. Knox, X.Z. Sun, P. Joseph, A.K. Jaiswal, D. Zhang, P.S. Deng, and S. Chen Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase Arch. Biochem. Biophys. 347 1997 221 228
-
(1997)
Arch. Biochem. Biophys.
, vol.347
, pp. 221-228
-
-
Wu, K.1
Knox, R.2
Sun, X.Z.3
Joseph, P.4
Jaiswal, A.K.5
Zhang, D.6
Deng, P.S.7
Chen, S.8
-
27
-
-
0029068515
-
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: Mechanism of the two-electron reduction
-
R. Li, M.A. Bianchet, P. Talalay, and L.M. Amzel The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction Proc. Natl. Acad. Sci. USA 92 1995 8846 8850
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8846-8850
-
-
Li, R.1
Bianchet, M.A.2
Talalay, P.3
Amzel, L.M.4
-
28
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
J.A. Bridgewater, C.J. Springer, R.J. Knox, N.P. Minton, N.P. Michael, and M.K. Collins Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954 Eur. J. Cancer 31A 1995 2362 2370
-
(1995)
Eur. J. Cancer
, vol.31
, pp. 2362-2370
-
-
Bridgewater, J.A.1
Springer, C.J.2
Knox, R.J.3
Minton, N.P.4
Michael, N.P.5
Collins, M.K.6
-
29
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
-
N. Wakabayashi, A.T. Dinkova-Kostova, W.D. Holtzclaw, M.I. Kang, A. Kobayashi, M. Yamamoto, T.W. Kensler, and P. Talalay Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers Proc. Natl. Acad. Sci. USA 101 2004 2040 2045
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
30
-
-
0344118703
-
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy
-
M.P. Hay, R.F. Anderson, D.M. Ferry, W.R. Wilson, and W.A. Denny Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy J. Med. Chem. 46 2003 5533 5545
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5533-5545
-
-
Hay, M.P.1
Anderson, R.F.2
Ferry, D.M.3
Wilson, W.R.4
Denny, W.A.5
-
31
-
-
0038101357
-
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase
-
M.P. Hay, G.J. Atwell, W.R. Wilson, S.M. Pullen, and W.A. Denny Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase J. Med. Chem. 46 2003 2456 2466
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2456-2466
-
-
Hay, M.P.1
Atwell, G.J.2
Wilson, W.R.3
Pullen, S.M.4
Denny, W.A.5
-
32
-
-
1942424798
-
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
-
N.A. Helsby, D.M. Ferry, A.V. Patterson, S.M. Pullen, and W.R. Wilson 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT Br. J. Cancer 90 2004 1084 1092
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1084-1092
-
-
Helsby, N.A.1
Ferry, D.M.2
Patterson, A.V.3
Pullen, S.M.4
Wilson, W.R.5
|