메뉴 건너뛰기




Volumn 110, Issue 12, 2007, Pages 4055-4063

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; DASATINIB; IMATINIB; NILOTINIB; OXIDOREDUCTASE; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE;

EID: 37049014938     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-07-102061     Document Type: Article
Times cited : (574)

References (47)
  • 1
    • 33846828641 scopus 로고    scopus 로고
    • The biology of chronic myelogenous leukemia: Implications for imatinib therapy
    • Alvarez RH, Kantarjian H, Cortes JE. The biology of chronic myelogenous leukemia: implications for imatinib therapy. Semin Hematol. 2007;44:4-14.
    • (2007) Semin Hematol , vol.44 , pp. 4-14
    • Alvarez, R.H.1    Kantarjian, H.2    Cortes, J.E.3
  • 2
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340:1330-1340.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 3
    • 4344623889 scopus 로고    scopus 로고
    • Imatinib as a paradigm of targeted therapies
    • Druker BJ. Imatinib as a paradigm of targeted therapies. Adv Cancer Res. 2004;91:1-30.
    • (2004) Adv Cancer Res , vol.91 , pp. 1-30
    • Druker, B.J.1
  • 4
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
    • Nagar B, Bornmann WG, Pellicena P, et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 2002;62:4236-4243.
    • (2002) Cancer Res , vol.62 , pp. 4236-4243
    • Nagar, B.1    Bornmann, W.G.2    Pellicena, P.3
  • 5
    • 0344626926 scopus 로고    scopus 로고
    • Structural basis for the autoinhibition of c-Abl tyrosine kinase
    • Nagar B, Hantschel O, Young MA, et al. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell. 2003;112:859-871.
    • (2003) Cell , vol.112 , pp. 859-871
    • Nagar, B.1    Hantschel, O.2    Young, M.A.3
  • 6
    • 33745081606 scopus 로고    scopus 로고
    • Circumventing resistance to kinase-inhibitor therapy
    • Druker BJ. Circumventing resistance to kinase-inhibitor therapy. N Engl J Med. 2006;354:2594-2596.
    • (2006) N Engl J Med , vol.354 , pp. 2594-2596
    • Druker, B.J.1
  • 7
    • 0345688603 scopus 로고    scopus 로고
    • Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias
    • Shah NP, Sawyers CL. Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias. Oncogene. 2003;22:7389-7395.
    • (2003) Oncogene , vol.22 , pp. 7389-7395
    • Shah, N.P.1    Sawyers, C.L.2
  • 8
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005;7:129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 9
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006;354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 10
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004;47:6658-6661.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 11
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004;305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 12
    • 37049035270 scopus 로고    scopus 로고
    • Giles F, le Coutre P, Bhalla K, et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to patients with imatinib resistant or intolerant chronic myelogenous leukemia (CML) in chronic phase (CP), accelerated phase (AP) or blast crisis (BC) who have also failed dasatinib therapy [abstract]. Blood (ASH Annual Meeting Abstracts). 2006;108:2170.
    • Giles F, le Coutre P, Bhalla K, et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to patients with imatinib resistant or intolerant chronic myelogenous leukemia (CML) in chronic phase (CP), accelerated phase (AP) or blast crisis (BC) who have also failed dasatinib therapy [abstract]. Blood (ASH Annual Meeting Abstracts). 2006;108:2170.
  • 13
    • 37049033775 scopus 로고    scopus 로고
    • Jabbour E, Jones D, Kantarjian H, et al. Dynamics of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia (CML) after treatment with one, two or three tyrosine kinase inhibitors (TKI) [abstract]. Blood (ASH Annual Meeting Abstracts). 2006;108:750.
    • Jabbour E, Jones D, Kantarjian H, et al. Dynamics of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia (CML) after treatment with one, two or three tyrosine kinase inhibitors (TKI) [abstract]. Blood (ASH Annual Meeting Abstracts). 2006;108:750.
  • 14
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 15
    • 23344440655 scopus 로고    scopus 로고
    • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    • Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A. 2005;102:11011-11016.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11011-11016
    • Carter, T.A.1    Wodicka, L.M.2    Shah, N.P.3
  • 16
    • 19744365702 scopus 로고    scopus 로고
    • A small molecule-kinase interaction map for clinical kinase inhibitors
    • Fabian MA, Biggs WH III, Treiber DK, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol. 2005;23:329-336.
    • (2005) Nat Biotechnol , vol.23 , pp. 329-336
    • Fabian, M.A.1    Biggs III, W.H.2    Treiber, D.K.3
  • 17
    • 0034086397 scopus 로고    scopus 로고
    • Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitors
    • Knockaert M, Gray N, Damiens E, et al. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem Biol. 2000;7:411-422.
    • (2000) Chem Biol , vol.7 , pp. 411-422
    • Knockaert, M.1    Gray, N.2    Damiens, E.3
  • 18
    • 33847016153 scopus 로고    scopus 로고
    • Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography
    • Guiffant D, Tribouillard D, Gug F, et al. Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography. Biotechnol J. 2007;2:68-75.
    • (2007) Biotechnol J , vol.2 , pp. 68-75
    • Guiffant, D.1    Tribouillard, D.2    Gug, F.3
  • 19
    • 9144219693 scopus 로고    scopus 로고
    • An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
    • Godl K, Wissing J, Kurtenbach A, et al. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc Natl Acad Sci U S A. 2003;100:15434-15439.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15434-15439
    • Godl, K.1    Wissing, J.2    Kurtenbach, A.3
  • 20
    • 29144453813 scopus 로고    scopus 로고
    • Characterisation of kinase-selective inhibitors by chemical proteomics
    • Daub H. Characterisation of kinase-selective inhibitors by chemical proteomics. Biochim Biophys Acta. 2005;1754:183-190.
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 183-190
    • Daub, H.1
  • 21
    • 1842499791 scopus 로고    scopus 로고
    • Profiling core proteomes of human cell lines by one-dimensional PAGE and liquid chromatography-tandem mass spectrometry
    • Schirle M, Heurtier MA, Kuster B. Profiling core proteomes of human cell lines by one-dimensional PAGE and liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics. 2003;2:1297-1305.
    • (2003) Mol Cell Proteomics , vol.2 , pp. 1297-1305
    • Schirle, M.1    Heurtier, M.A.2    Kuster, B.3
  • 22
    • 33750492575 scopus 로고    scopus 로고
    • Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor
    • Jamieson D, Tung AT, Knox RJ, Boddy AV. Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor. Br J Cancer. 2006;95:1229-1233.
    • (2006) Br J Cancer , vol.95 , pp. 1229-1233
    • Jamieson, D.1    Tung, A.T.2    Knox, R.J.3    Boddy, A.V.4
  • 24
    • 33745283618 scopus 로고    scopus 로고
    • The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
    • Tokarski JS, Newitt JA, Chang CY, et al. The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res. 2006;66:5790-5797.
    • (2006) Cancer Res , vol.66 , pp. 5790-5797
    • Tokarski, J.S.1    Newitt, J.A.2    Chang, C.Y.3
  • 25
    • 0027157692 scopus 로고
    • A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain
    • Johnson JD, Edman JC, Rutter WJ. A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc Natl Acad Sci U S A. 1993;90:5677-5681.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5677-5681
    • Johnson, J.D.1    Edman, J.C.2    Rutter, W.J.3
  • 26
    • 34548097263 scopus 로고    scopus 로고
    • The Btk tyrosine kinase, is a major target of the anti-leukemic Bcr-Abl inhibitor dasatinib
    • Hantschel O, Rix U, Schmidt U, et al. The Btk tyrosine kinase, is a major target of the anti-leukemic Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A. 2007;104:13283-13288.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13283-13288
    • Hantschel, O.1    Rix, U.2    Schmidt, U.3
  • 27
    • 0035830855 scopus 로고    scopus 로고
    • Identification and characterization of a novel MAP kinase kinase kinase, MLTK
    • Gotoh I, Adachi M, Nishida E. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. J Biol Chem. 2001;276:4276-4286.
    • (2001) J Biol Chem , vol.276 , pp. 4276-4286
    • Gotoh, I.1    Adachi, M.2    Nishida, E.3
  • 28
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005;5:172-183.
    • (2005) Nat Rev Cancer , vol.5 , pp. 172-183
    • Ren, R.1
  • 29
    • 32344451150 scopus 로고    scopus 로고
    • Regulating the regulator: Negative regulation of Cbl ubiquitin ligases
    • Ryan PE, Davies GC, Nau MM, Lipkowitz S. Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends Biochem Sci. 2006;31:79-88.
    • (2006) Trends Biochem Sci , vol.31 , pp. 79-88
    • Ryan, P.E.1    Davies, G.C.2    Nau, M.M.3    Lipkowitz, S.4
  • 30
    • 33745749038 scopus 로고    scopus 로고
    • The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas
    • Paterson JC, Tedoldi S, Craxton A, et al. The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas. Haematologica. 2006;91:772-780.
    • (2006) Haematologica , vol.91 , pp. 772-780
    • Paterson, J.C.1    Tedoldi, S.2    Craxton, A.3
  • 31
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet. 2004;36:453-461.
    • (2004) Nat Genet , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3
  • 33
    • 4444267291 scopus 로고    scopus 로고
    • Crystal structure of quinone reductase 2 in complex with resveratrol
    • Buryanovskyy L, Fu Y, Boyd M, et al. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry. 2004;43:11417-11426.
    • (2004) Biochemistry , vol.43 , pp. 11417-11426
    • Buryanovskyy, L.1    Fu, Y.2    Boyd, M.3
  • 34
    • 0033520090 scopus 로고    scopus 로고
    • Crystal structure of human quinone reductase type 2, a metalloflavoprotein
    • Foster CE, Bianchet MA, Talalay P, Zhao Q, Amzel LM. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. Biochemistry. 1999;38:9881-9886.
    • (1999) Biochemistry , vol.38 , pp. 9881-9886
    • Foster, C.E.1    Bianchet, M.A.2    Talalay, P.3    Zhao, Q.4    Amzel, L.M.5
  • 35
    • 33746628593 scopus 로고    scopus 로고
    • Case histories, magic bullets and the state of drug discovery
    • Drews J. Case histories, magic bullets and the state of drug discovery. Nat Rev Drug Discov. 2006;5:635-640.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 635-640
    • Drews, J.1
  • 36
    • 31144438390 scopus 로고    scopus 로고
    • Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology
    • van der Greef J, McBurney RN. Innovation: rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat Rev Drug Discov. 2005;4:961-967.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 961-967
    • van der Greef, J.1    McBurney, R.N.2
  • 37
    • 0042305479 scopus 로고    scopus 로고
    • Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
    • Gambacorti-Passerini C, Zucchetti M, Russo D, et al. Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res. 2003;9:625-632.
    • (2003) Clin Cancer Res , vol.9 , pp. 625-632
    • Gambacorti-Passerini, C.1    Zucchetti, M.2    Russo, D.3
  • 38
  • 39
    • 0842278630 scopus 로고    scopus 로고
    • Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: Role of p38 mitogen-activated protein kinase and NF-kappa B
    • Matsuyama W, Wang L, Farrar WL, Faure M, Yoshimura T. Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B. J Immunol. 2004;172:2332-2340.
    • (2004) J Immunol , vol.172 , pp. 2332-2340
    • Matsuyama, W.1    Wang, L.2    Farrar, W.L.3    Faure, M.4    Yoshimura, T.5
  • 40
    • 18244384959 scopus 로고    scopus 로고
    • Discoidin domain receptor 1: A new class of receptor regulating leukocyte-collagen interaction
    • Yoshimura T, Matsuyama W, Kamohara H. Discoidin domain receptor 1: a new class of receptor regulating leukocyte-collagen interaction. Immunol Res. 2005;31:219-230.
    • (2005) Immunol Res , vol.31 , pp. 219-230
    • Yoshimura, T.1    Matsuyama, W.2    Kamohara, H.3
  • 41
    • 33645320530 scopus 로고    scopus 로고
    • Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2
    • Ram R, Lorente G, Nikolich K, Urfer R, Foehr E, Nagavarapu U. Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2. J Neurooncol. 2006;76:239-248.
    • (2006) J Neurooncol , vol.76 , pp. 239-248
    • Ram, R.1    Lorente, G.2    Nikolich, K.3    Urfer, R.4    Foehr, E.5    Nagavarapu, U.6
  • 42
    • 3042736088 scopus 로고    scopus 로고
    • Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    • Heinzelmann-Schwarz VA, Gardiner-Garden M, Henshall SM, et al. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clin Cancer Res. 2004;10:4427-4436.
    • (2004) Clin Cancer Res , vol.10 , pp. 4427-4436
    • Heinzelmann-Schwarz, V.A.1    Gardiner-Garden, M.2    Henshall, S.M.3
  • 43
    • 28644440460 scopus 로고    scopus 로고
    • Involvement of discoidin domain receptor 1 in the deterioration of pulmonary sarcoidosis
    • Matsuyama W, Mitsuyama H, Watanabe M, et al. Involvement of discoidin domain receptor 1 in the deterioration of pulmonary sarcoidosis. Am J Respir Cell Mol Biol. 2005;33:565-573.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 565-573
    • Matsuyama, W.1    Mitsuyama, H.2    Watanabe, M.3
  • 44
    • 0034954802 scopus 로고    scopus 로고
    • Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium
    • Sakamoto O, Suga M, Suda T, Ando M. Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium. Eur Respir J. 2001;17:969-974.
    • (2001) Eur Respir J , vol.17 , pp. 969-974
    • Sakamoto, O.1    Suga, M.2    Suda, T.3    Ando, M.4
  • 45
    • 0023159991 scopus 로고
    • Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients
    • Maxwell SA, Kurzrock R, Parsons SJ, et al. Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients. Cancer Res. 1987;47:1731-1739.
    • (1987) Cancer Res , vol.47 , pp. 1731-1739
    • Maxwell, S.A.1    Kurzrock, R.2    Parsons, S.J.3
  • 46
    • 19944434293 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase: Cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
    • Lindvall JM, Blomberg KE, Valiaho J, et al. Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Immunol Rev. 2005;203:200-215.
    • (2005) Immunol Rev , vol.203 , pp. 200-215
    • Lindvall, J.M.1    Blomberg, K.E.2    Valiaho, J.3
  • 47
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood. 2003;101:690-698.
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.