Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 696-706

  Nolan, Karen A ^a   Humphries, Matthew P ^a   Barnes, John ^a   Doncaster, Jeremy R ^a   Caraher, Mary C ^a   Tirelli, Nicola ^a   Bryce, Richard A ^a   Whitehead, Roger C ^a   Stratford, Ian J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Molecular modelling; NQ01; NQ02; Structure activity relationship; Toxicity

Indexed keywords

NAD(P)H:QUINONE OXIDOREDUCTASE 1; NRH:QUINONE OXIDOREDUCTASE 2; NSC 6455827; NSC 645827; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRIAZOLOACRIDIN 6 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CORRELATION COEFFICIENT; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACRIDINES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); QUINONE REDUCTASES; SALMON; SPERMATOZOA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE; TRIAZOLES;

EID: 76449088132     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.059     Document Type: Article

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