Novel inhibitors of NRH:Quinone oxidoreductase 2 (NQO2): Crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6597-6611

  Dunstan, Mark S ^a   Barnes, John ^a   Humphries, Matthew ^a   Whitehead, Roger C ^a   Bryce, Richard A ^a   Leys, David ^a   Stratford, Ian J ^a   Nolan, Karen A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 (DIETHYLAMINO)ETHYLAMINO] 8 HYDROXY 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 6H IMIDAZO [4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 BROMO 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 BROMO 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 FLUORO 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 FLUORO 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 FLUORO 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 FLUORO 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 HYDROXY 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 HYDROXY 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 HYDROXY 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 METHOXY 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 METHOXY 1 METHYL 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 METHOXY 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE; 5 [2 (DIMETHYLAMINO)ETHYLAMINO] 8 METHOXY 6H IMIDAZO[4,5,1 DE]ACRIDIN 6 ONE N OXIDE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; IMIDACRINE; IMIDAZOLE DERIVATIVE; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACRIDINES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINONE REDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053899562     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200416e     Document Type: Article

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