Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 1873-1884

  Maiti, Arup ^a   Reddy, P V Narasimha ^a   Sturdy, Megan ^b   Marler, Laura ^c   Pegan, Scott D ^b   Mesecar, Andrew D ^b   Pezzuto, John M ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF HAWAII AT HILO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIMETHYLQUINOLIN 2(1H) ONE; 2,3 DIMETHOXY N METHYLANILINE; 2,3,4 TRIMETHOXY N METHYLANILINE; 2,3,4 TRIMETHOXYANILINE; 2,4 DIMETHOXY N METHYLANILINE; 2,4 DIMETHOXYANILINE; 2,4,5 TRIMETHOXYANILINE; 3 AMINOVERATROLE; 4 METHYLQUINOLIN 2(1H) ONE; 5,6,7,8 TETRAMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 5,6,7,8 TETRAMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 5,6,8 TRIMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 5,6,8 TRIMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 5,8 DIMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 5,8 DIMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 6 METHYL [1,3]DIOXOLO[4,5 H]QUINOLIN 8(9H) ONE; 6,7,8 TRIMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 6,7,8 TRIMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 6,8 DIMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 6,8 DIMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 6,9 DIMETHYL [1,3]DIOXOLO[4,5 H]QUINOLIN 8(9H)-ONE; 7,8 DIMETHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 7,8 DIMETHOXY 4 METHYLQUINOLIN 2(1H) ONE; 8 METHOXY 1,4 DIMETHYLQUINOLIN 2(1H) ONE; 8 METHOXY 4 METHYLQUINOLIN 2(1H) ONE; ANTINEOPLASTIC AGENT; BENZO[D][1,3]DIOXOL 4 AMINE; CASIMIROIN; N METHYLBENZO[D][1,3]DIOXOL 4 AMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CASIMIROA; CASIMIROA EDULIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; AROMATASE; AROMATASE INHIBITORS; BENZODIOXOLES; CASIMIROA; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FRUIT; HUMANS; MICE; MODELS, MOLECULAR; QUINOLONES; QUINONE REDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549085357     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801335z     Document Type: Article

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