Kinetic Mechanism of Quinone Oxidoreductase 2 and Its Inhibition by the Antimalarial Quinolines

Biochemistry

Volumn 43, Issue 15, 2004, Pages 4538-4547

  Kwiek, Jesse J ^a,c   Haystead, Timothy A J ^a,b   Rudolph, Johannes ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Serenex Inc   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CATALYSIS; CELLS; DRUG PRODUCTS; ENZYMES; MALARIA CONTROL; OXIDATION; PHYSIOLOGY; REACTION KINETICS; REDUCTION;

ANTIMALARIAL COMPOUNDS; BINDING SITES; RED BLOOD CELLS; TRANSITION STATE KINETICS;

BIOCHEMICAL ENGINEERING;

ANTIMALARIAL AGENT; CHLOROQUINE; FLAVINE ADENINE NUCLEOTIDE; MEPACRINE; NICOTINAMIDE; PRIMAQUINE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 2 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CATALYST; DRUG POTENCY; ELECTRON; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME KINETICS; ENZYME METABOLISM; ERYTHROCYTE; ESCHERICHIA COLI; HUMAN; LIVER CELL; MALARIA; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REDUCTION; STEADY STATE;

ANTIMALARIALS; BINDING, COMPETITIVE; CHLOROQUINE; COPPER; HUMANS; KINETICS; NIACINAMIDE; OXIDATION-REDUCTION; PRIMAQUINE; QUINACRINE; QUINOLINES; QUINONE REDUCTASES; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; ZINC;

ESCHERICHIA COLI; PROTOZOA;

EID: 4444265496     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035923w     Document Type: Article

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