Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from streptomyces species, strain CNS284

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8688-8699

  Conda Sheridan, Martin ^a   Marler, Laura ^b   Park, Eun Jung ^b   Kondratyuk, Tamara P ^b   Jermihov, Katherine ^a   Mesecar, Andrew D ^a   Pezzuto, John M ^b   Asolkar, Ratnakar N ^c   Fenical, William ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF HAWAII AT HILO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHOXYBENZO[B]PHENAZINE; 2 BROMO 1 HYDROXYPHENAZINE; ANTINEOPLASTIC AGENT; DRUG METABOLITE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; QUINONE REDUCTASE 1; QUINONE REDUCTASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INDUCTION; ENZYME INHIBITION; FUNGAL STRAIN; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STREPTOMYCES; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICARCINOGENIC AGENTS; AQUATIC ORGANISMS; CELL LINE; CELL LINE, TUMOR; ENZYME INDUCTION; HUMANS; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHENAZINES; QUINONE REDUCTASES; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650354600     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1011066     Document Type: Article

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