Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor

British Journal of Cancer

Volumn 95, Issue 9, 2006, Pages 1229-1233

  Jamieson, D ^a   Tung, A T Y ^b   Knox, R J ^a   Boddy, A V ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

Bioreductive drugs; Mitomycin C; NQO1; NQO2

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; DIHYDRONICOTINAMIDE RIBOSIDE; MITOMYCIN C; NICOTINAMIDE DERIVATIVE; OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE 1; QUINONE OXIDOREDUCTASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER; CANCER RESEARCH; CATALYSIS; CELL LINE; CELL STRAIN V 79; CONTROLLED STUDY; DNA ALKYLATION; DNA CROSS LINKING; DRUG METABOLISM; ELECTRON TRANSPORT; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; REDUCTION;

ALKYLATING AGENTS; ANIMALS; AZIRIDINES; CATALYSIS; CELL LINE; COMET ASSAY; ELECTRON TRANSPORT; HUMANS; MITOMYCIN; NAD; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; QUERCETIN; QUINONE REDUCTASES; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 33750492575     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603414     Document Type: Article

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