Structure-activity relationships imply different mechanisms of action for ochratoxin A-mediated cytotoxicity and genotoxicity

Chemical Research in Toxicology

Volumn 25, Issue 1, 2012, Pages 181-190

  Hadjeba Medjdoub, Kheira ^a   Tozlovanu, Mariana ^a   Pfohl Leszkowicz, Annie ^a   Frenette, Christine ^b   Paugh, Robert J ^b   Manderville, Richard A ^b  

^a LABORATOIRE DE GÉNIE CHIMIQUE   (France)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE DERIVATIVE; BROMOOCHRATOXIN; DEOXYGUANOSINE; DNA; GLUTATHIONE; HYDROQUINONE DERIVATIVE; N [(5,8 DIHYDROXY 3 METHY 1 OXO 3,4 DIHYDRO 1H ISOCHROMEN 7 YL)CARBONY]PHENYLALANINE; N [(8 HYDROXY 3 METHYL 1 OXO 3,4 1H ISOCHROMEN 7 YL)CARBONYL]PHENYLALANINE; OCHRATOXIN; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA ADDUCT; DNA ADDUCTION; DNA DAMAGE; EPITHELIUM CELL; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; OPOSSUM; OXIDATIVE STRESS; PHOTOCHEMISTRY; PHOTODEGRADATION; PHOTOREACTIVITY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BIOTRANSFORMATION; CELL LINE; CELL SURVIVAL; DEOXYGUANOSINE; DNA ADDUCTS; GLUTATHIONE; HUMANS; LIGHT; MUTAGENS; MYCOTOXINS; OCHRATOXINS; OPOSSUMS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; DIDELPHIDAE;

EID: 84855841205     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200406c     Document Type: Article

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