Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 343-347

  Cramer, Benedikt ^a   Harrer, Henning ^a   Nakamura, Kazuhiko ^b   Uemura, Daisuke ^b   Humpf, Hans Ulrich ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b KEIO UNIVERSITY   (Japan)

Author keywords

14 (R) Ochratoxin A; Cell culture; Cytotoxicity; Mould; Mycotoxin; Ochratoxin A; OTA; Protein biosynthesis; Toxicity

Indexed keywords

CASPASE 3; OCHRATOXIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL;

APOPTOSIS; CYTOTOXINS; HEP G2 CELLS; HUMANS; MOLECULAR STRUCTURE; OCHRATOXINS; STEREOISOMERISM;

EID: 72049115482     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.050     Document Type: Article

References (29)

1. Van der Merwe K.J., Steyn P.S., Fourie L., Scott D.B., and Theron J.J. Nature 205 (1965A) 1112-1113
2. Battilani P., and Pietri A. Eur. J. Plant Pathol. 108 (2002) 639-643
3. Bonvehi J.S. J. Agric. Food Chem. 52 (2004) 6347-6352
4. Degelmann P., Becker M., Herderich M., and Humpf H.U. Chromatographia 49 (1999) 543-546
5. EFSA. EFSA J. 365 (2006) 1-56
6. Scott P.M., Van Walbeek W., Kennedy B., and Anyeti D. J. Agric. Food Chem. 20 (1972) 1103-1109
7. IARC. In IARC Monographs On the Evaluation of Carcinogenic Risks to Humans; WHO: Lyon, 1993; Vol. 56, pp. 489-521.
8. Gekle M., Sauvant C., and Schwerdt G. Mol. Nutr. Food Res. 49 (2005) 118-130
9. Pfohl-Leszkowicz A., and Manderville R.A. Mol. Nutr. Food Res. 51 (2007) 61-99
10. Delatour T., Mally A., Richoz J., Özden S., Dekant W., Ihmels H., Otto D., Gasparutto D., Marin-Kuan M., Schilter B., and Cavin C. Mol. Nutr. Food Res. 52 (2008) 472-482
11. Konrad I., and Roeschenthaler R. FEBS Lett. 83 (1977) 341-347
12. Roth A., Eriani G., Dirheimer G., and Gangloff J. FEBS Lett. 326 (1993) 87-91
13. McMasters D.R., and Vedani A. J. Med. Chem. 42 (1999) 3075-3086
14. Cramer B., Königs M., and Humpf H.-U. J. Agric. Food Chem. 56 (2008) 5673-5681
15. Ishiyama M., Tominaga H., Shiga M., Sasamoto K., Ohkura Y., and Ueno K. Biol. Pharm. Bull. 19 (1996) 1518-1520
16. Königs M., Schwerdt G., Gekle M., and Humpf H.-U. Mol. Nutr. Food Res. 52 (2008) 830-839
17. Karvinen J., Hurskainen P., Gopalakrishnan S., Burns D., Warrior U., and Hemmilà I. J. Biomol. Screening 7 (2002) 223-231
18. Weidmann E., Brieger J., Jahn B., Hoelzer D., Bergmann L., and Mitrou P.S. Ann. Hematol. 70 (1995) 153-158
19. Donner C.D., and Gill M. Aust. J. Chem. 55 (2002) 213-217
20. Kraus G.A. J. Org. Chem. 46 (1981) 201-202
21. Steyn P.S., and Holzapfel C.W. Tetrahedron 23 (1967) 4449-4461
22. Covarrubias-Zuniga A., and Rios-Barrios E. J. Org. Chem. 62 (1997) 5688-5689
23. Krogh P., Hald B., Plestina R., and Ceovic S. Acta Pathol. Microbiol. Scand. B 85 (1977) 238-240
24. Berndt W.O., and Hayes A.W. Toxicology 12 (1979) 5-17
25. Gekle M., Sauvant C., Schwerdt G., and Silbernagl S. Kidney Blood Press. Res. 21 (1998) 277-279
26. Petkova-Bocharova T., and Castegnaro M. IARC Sci. Publ. (1991) 135-137
27. Petrik J., Zanic-Grubisic T., Barisic K., Pepeljnjak S., Radic B., Ferencic Z., and Cepelak I. Arch. Toxicol. 77 (2003) 685-693
28. Schwerdt G., Freudinger R., Mildenberger S., Silbernagl S., and Gekle M. Cell. Biol. Toxicol. 15 (1999) 405-415
29. Sauvant C., Holzinger H., and Gekle M. Cell. Physiol. Biochem. 15 (2005) 125-134