Roles of cyclooxygenase and lipoxygenases in ochratoxin A genotoxicity in human epithelial lung cells

Environmental Toxicology and Pharmacology

Volumn 7, Issue 2, 1999, Pages 95-107

  Pinelli, Eric ^a   El Adlouni, Chakib ^a,c   Pipy, Bernard ^b   Quartulli, Fabio ^b   Pfohl Leszkowicz, Annie ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b CHU RANGUEIL   (France)

^c FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Bronchial epithelial cells; DNA adduct; Genotoxicity; Lipoxygenase; Ochratoxin A; Ochratoxin A metabolites; Pig seminal vesicle; Prostaglandin synthase

Indexed keywords

ADRENALIN; INDOMETACIN; LEUKOTRIENE C4; LIPOXYGENASE; NORDIHYDROGUAIARETIC ACID; OCHRATOXIN; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; DNA ADDUCT; EPITHELIUM CELL; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; METABOLITE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; SEMINAL VESICLE; SWINE;

SUS SCROFA;

EID: 0032901070     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(99)00008-3     Document Type: Review

References (64)

1. Alric L., Pinelli E., Carrera G., Vinel J.P., Beraud M., Duffaut M., Pascal J.P., Pipy B. Involvement of calcium in macrophage leucotriene release during experimental cirrhosis. Hepathology. 23:1996;614.
2. Anzenbacher P., Soucek P., Anzenbacherova E., Gut I., Kruky K., Svoboda Z., Kvetina J. Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Drug Metab. Dispos. 26:1998;56.
3. Bendele A.M., Carlton W.W., Krogh P., Lillehoj E.B. Ochratoxin A carcinogenesis in the (C57BL/6J×C3H) F1 mouse. J. Natl. Cancer Inst. 75:1985;733.
4. Boorman, G. (Ed.) 1989. NTP technical report on the toxicology and carcinogenesis studies of ochratoxin A in F344/N rats, NIH publication No. 89-2813, US Department of Health and Human services, NIH, Research Triangle Park, NC, USA.
5. Bose S., Sinha S.P. Modulation of ochratoxin-produced genotoxicity in mice by vitamin C. Food Chem. Toxic. 32:1994;533.
6. Capdevila J.H., Falck J.R., Estabrook R.W. Cytochrome P450 and the arachidonate cascade. FASEB J. 6:1992;731.
7. Castegnaro M., Bartsch H., Chernozemsky I.V. Endemic nephropathy and urinary tract tumors in the Balkans. Cancer Res. 47:1987;3608.
8. Castegnaro M., Mohr U., Pfohl-Leszkowicz A., Estève J., Tillman T., Michelon J., Bartsch H. Sex and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction. Int. J. Cancer. 77:1998;70.
9. Degen G.H., Gerber M.M., Obrecht-Pflumio S., Pfohl-Leszkowicz A., Dirheimer G. Genotoxicity and cytotoxicity of ochratoxin A in ovine seminal vesicle cell cultures. Naunyn-Schmiedeberg's Arch. Pharmacol. (Suppl.). 349:1994;R121.
10. Degen G.H., Gerber M.M., Obrecht-Pflumio S., Dirheimer G. Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Arch. Toxicol. 71:1997;365.
11. Di Paolo N., Guarnieri A., Loi F., Sacchi G., Mangiarotti A.M., Di Paolo M. Acute renal failure from inhalation of mycotoxins. Nephron. 64:1993;621.
12. Eling T.E., Thompson D.C., Fouremen G.L., Curtis J.F., Hughes M.F. Prostaglandin-H-synthase and xenobiotic oxidation. Annu. Rev. Pharmacol. Toxicol. 30:1990;1-45.
13. Goetzl E.J., Songzhu A., Smith W. Specificity of expression and effects of ecosanoid mediators in normal physiology and human diseases. FASEB J. 9:1995;1051.
14. Green C.J. Animal Anaesthesia. 1979;Laboratory Animals Ltd, London.
15. de Groene E.M., Hassing G.I.A., Blom M.J., Seinen W., Fink-Gremmels J., Horbach G.J.M.J. Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. Cancer Res. 56:1996;299.
16. Grosse Y., Baudrimont I., Castegnaro M., Creppy E.E., Dirheimer G., Pfohl-Leszkowicz A. Ochratoxin A metabolites and DNA-adducts formation in monkey kidney cell. Chem. Biol. Interact. 95:1995;175.
17. Grosse Y., Chekir-Ghedira L., Huc A., Obrecht-Pflumio S., Dirheimer G., Bacha H., Pfohl-Leszkowicz A. Retinol, ascorbic acid and alpha tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone. Cancer Lett. 114:1997;225.
18. Grosse Y., Monje M.C., Macé K., Pfeifer A., Pfohl-Leszkowicz A. Use of bronchial epithelial cells expressing human cytochrome P450 for study on metabolism and genotoxicity of ochratoxin A. In Vitro Toxicol. 10:1997;97.
19. Henke D., Danilowicz R.M., Curtis J.F., Boucher R.C., Eling T.E. Metabolism of arachidonic acids by human nasal and bronchial epithelia cells. Arch. Biochem. Biophys. 268:1988;426.
20. Hennig A., Finks-Gremmels J., Leistner L. Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation. Castegnaro M., Plestina R., Dirheirmer G., Chernozemsky I.N., Bartsch H. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours No. 115. 1991;255 IARC Scientific Publications, Lyon.
21. Hoehler D., Marquadt R.R., Frohlich A.A. Lipide peroxidation as one mode of action in ochratoxin A toxicity in rats and chicks. Can. J. Anim. Sci. 77:1997;287.
22. Hoehler D., Marquadt R.R., McIntosh A.R., Hatch G.M. Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Biochem. Biophys. Acta. 1357:1997;225.
23. Holtzmann M.J. Arachidonic acid metabolism in airway epithelial cells. Annu. Rev. Physiol. 54:1992;303.
24. Hughes M.F., Chamulitrat W., Mason W., Eling T.E. Epoxydation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene via a hydroperoxidase-dependent mechanism catalyzed by lipoxygenases. Carcinogenesis. 10:1989;127.
25. Hunter J.A., Finkbeiner W.E., Nadel J.A., Goetzl E.J., Holtzman M.J. Predominant generation of 5-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. PNAS. 82:1985;4633.
26. 32P-postlabeling. Free Rad. Res. 28:1998;165.
27. Krogh P. Ochratoxin A residues in tissues of slaughter pigs with nephropathy. Nord Vet. Med. 29:1977;402-408.
28. Lash L.H. Role of renal metabolism in risk to toxic chemicals. Environ. Health Perspect. 102:1994;75.
29. Li S., Marquardt A., Frohlich A., Vitti T.G., Crow G. Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145:1997;82.
30. Liu L., Massey T.E. Bioactivation of aflatoxin B1 by lipoxygenase, prostaglandin H synthase and sytochrome P450 monooxygenase in guinea-pig tissues. Carcinogenesis. 13:1992;533.
31. Lutz W., Gaylor D. Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence. Regul. Toxicol. Pharmacol. 23:1996;29.
32. Malaveille C., Brun G., Bartsch H. Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. Castegnaro M., Plestina R., Dirheimer G., Chernozemsky I.N., Bartsch H. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours No. 115. 1991;261 IARC Scientific Publications, Lyon.
33. Manolova Y., Manolov G., Parvanova L., Petkova-Bocharova T., Castegnaro M., Chernozemsky I.N. Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy. Mutat. Res. 231:1990;143.
34. Markey C.M., Alward A., Weller P.E., Marnett L.J. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. J. Biol. Chem. 262:1987;6266.
35. McGiff J.C. Cytochrome P6450 metabolism of arachidonic acid. Annu. Rev. Toxicol. 31:1991;339.
36. Meade E., Smith A.W.L., DeWitt D.L. Differential inhibition of prostaglandin endoperoxide synthase isoenzymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:1993;6610.
37. Miller J.A., Miller E.C. Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res. 38:1981;1476.
38. Munday R. Bioactivation of thiols by one-electron oxidation. Adv. Pharmacol. 27:1994;237.
39. Obrecht-Pflumio S., Grosse Y., Pfohl-Leszkowicz A., Dirheimer G. Protection by indomethacin and aspirin against genotoxicity of ochratoxin A, particulary in the urinary bladder and kidney. Arch. Toxicol. 70:1996;277.
40. Namara P.J. Interspecies scaling in pharmacokinetics. Welling P.J., Tse F.L.S., Dighe S.V. Pharmaceutical Bioequivalence. 1991;267-300 Marcel Dekker, New York.
41. Oliw E.H. Biosynthesis of 18 (RD)-hydroeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. Some properties of a novel fatty acid omega 3-hydroxylase and omega 3-epoxygenase. J. Biol. Chem. 264:1989;17845.
42. Omar R.F., Hasinoff B.B., Mejilla F., Rahimtula A.D. Mechanism of ochratoxin A stimulated lipid peroxidation. Biochem. Pharmacol. 40:1990;1183.
43. Omar R.F., Gleboin H.V., Rahimtula D. Effect of cytochrome P450 induction on the metabolism and toxicity of ochratoxin A. Biochem. Pharmacol. 51:1996;207.
44. Pfohl-Leszkowicz A., Chakor K., Creppy E.E., Dirheimer G. DNA adduct formation in mice treated with ochratoxin A. Castegnaro M., Plestina R., Dirheimer G., Chernozemsky I.N., Bartsch H. Mycotoxin, Endemic Nephropathy and Urinary Tract Tumours No.115. 1991;245 IARC Scientific Publication, Lyon.
45. Pfohl-Leszkowicz A., Grosse Y., Kane A., Creppy E.E., Dirheimer G. Differential DNA adduct formation and disappearance in three mice tissues after treatment by the mycotoxin ochratoxin A. Mutat. Res. 289:1993;265.
46. Pfohl-Leszkowicz A., Grosse Y., Castegnaro M., Petkova-Bocharova T., Nicolov I.G., Chernozemsky I.N., Bartsch H., Betbeder A.M., Creppy E.E., Dirheimer G. Ochratoxin A related DNA adducts in urinary tract tumours of Bulgarian subjects. Phillips D.H., Castegnaro M., Bartsch H. Postlabelling Methods for Detection of DNA Adducts No. 124. 1993;141 IARC Scientific Publications, Lyon.
47. Pfohl-Leszkowicz, A., Grosse, Y., Kane, A., Gharbi, A., Baudrimont, I., Obrecht, S., Creppy, E.E., Dirheimer, G., 1993c. Is the oxidative pathway implicated in the genotoxicity of ochratoxin A? In Human Ochratoxicosis and its Pathologies. John Libbey Eurotext, Colloque INSERM, 231, 177.
48. Pfohl-Leszkowicz A., Obrecht S., Grosse Y., Dirheimer G. Involvement of antioxydants and inhibitors of glutathione conjugation in ochratoxin A genotoxicity in mice liver and kidney. Toxicol. Lett. 74:1994;64.
49. Pfohl-Leszkowicz A., Pinelli E., Bartsch H., Mohr U., Castegnaro M. Sex and Strain differences in ochratoxin A metabolism and DNA adduction in two strains of rats. Molec. Carcinogen. 32:1998;70.
50. Pinelli E., Monje M.C., El Adlouni C., Marty J., Grosse Y., Pfohl-Leszkowicz A. Phenobarbital enhanced genotoxicity of ochratoxin A. Cell Biol. Toxicol. 12:1996;392.
51. Ploemen J.H.T, . van Ommen B., van Bladeren P.J. Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. Biochem. Pharmacol. 40:1990;1631.
52. Rahimtula A., Bereziat J.C., Bussacchini-Griot V., Bartsch H. Lipid peroxydation as a possible cause of ochratoxin A toxicity. Biochem. Pharmacol. 37:1988;4469.
53. Randerath K., Randerath E., Smith C.V., Chang J. Structural origins of bulky oxidative DNA adducts (type II-I compounds) as deduced by oxidation of oligonucleotides of known sequence. Chem. Res. Toxicol. 9:1996;247.
54. Reddy M.V., Randerath K. Nuclease P1 mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA-adducts. Carcinogensis. 7:1986;1543.
55. Reed G.A. Oxidation of environmental carcinogens by prostaglandins H synthase. Environ. Carcinogen. Rev. 6:1988;223.
56. Rendic B., Di Carlo F.J. Human cytochrome P450 enzymes: a status summarizing their reactions, inducers and inhibitors. Drug Metab. Rev. 29:1997;413.
57. Roy P., Sajan M.P., Kulkarni A.P. Lipoxygenase-mediated glutathione oxidation and superoxide generation. J. Biochem. Toxicol. 10:1995;111-120.
58. Scoggan K.A., Jakobsson P.-J., Ford-Hutchinson A.W. Production of leukotrien C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. J. Biol. Chem. 272:1997;10182.
59. Shinjo F., Yoshimoto T., Yokoyama C., Yamamoto S., Izumi S.-I., Komatsu N., Watanabe K. Studies on porcine arachidonate 12-lipoxygenase using its monoclonal antibodies. J. Biol. Chem. 261:1986;3377.
60. Smith W.L., Marnett L.J., DeWitt D.L. Prostaglandin and thromboxane synthesis. Pharmacol. Ther. 49:1991;153.
61. Størmer F.C. Ochratoxin A. A mycotoxin of concern. Bhatnagar D., Lillehoj E.B., Arora D.K. Handbook of Applied Mycology. 1992;403 Marcel Dekker, New York.
62. Vukelic M., Sostaric B., Belicza M. Pathomorphology of Balkan endemic nephropathy. Food. Chem. Toxicol. 30:1992;193.
63. Xiao H., Marquadt R.R, Abramson D., Frohlich A. Metabolites of ochratoxins in rat urine and in a culture of Aspergillus ochraceus. Appl. Environ. Microbiol. 62:1996;648.
64. Yamamoto S. Mammalian lipoxygenases: molecular structures and functions. Biochim. Biophys. Acta. 1128:1992;117.