Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 234-241

  Sauvant, Christoph ^a   Holzinger, H ^a   Gekle, M ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACTIN; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYCOTOXIN; OCHRATOXIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME RELEASE; FIBROSIS; INFLAMMATION; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY TRACT TUMOR;

ALKALINE PHOSPHATASE; CASPASE 3; CASPASES; COLLAGEN; CYTOSOL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; L-LACTATE DEHYDROGENASE; NF-KAPPA B; OCHRATOXINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 15744381934     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.079475     Document Type: Article

References (40)

1. Anonymous (1993) Ochratoxin A. IARC Monogr Eval Carcinog Risks Hum 56:489-521.
2. 2) cytotoxicity in mouse renal proximal tubule cells. Kidney Int 65:1231-1239.
3. Aukema HM, House JD, Bankovic-Calic N, and Ogborn MR (2004) Increased renal fibrosis and expression of renal phosphatidylinositol 4-kinase-beta and phospholipase C(gammal) proteins in piglets exposed to ochratoxin-A. Nephron Physiol 96:P19-25.
4. Benesic A, Mildenberger S, and Gekle M (2000) Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells. Pflugers Arch 439:278-287.
5. di Mari JF, Davis R, and Safirstein RL (1999) MAPK activation determines renal epithelial cell survival during oxidative injury. Am J Physiol 277:F195-F203.
6. Evan GI and Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature (Lond) 411:342-348.
7. Gekle M, Knaus P, Nielsen R, Mildenberger S, Freudinger R, Wohlfarth V, Sauvant C, and Christensen EI (2003) TGFβ1 reduces megalin/cubilin-mediated endocytosis of albumin in proximal tubule-derived OK-cells. Nephrol Dial Transplant 18 (Suppl 4):561.
8. Gekle M, Sauvant C, Schwerdt G, and Silbernagl S (1998) Tubulotoxic mechanisms of Ochratoxin A. Kidney Blood Press Res 21:277-279.
9. Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilflingseder D, Pollack V, Dander M, and Schramek H (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 293:837-844.
10. Horvath A, Upham BL, Ganev V, and Trosko JE (2002) Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40:273-282.
11. Hou DX, Kai K, Li JJ, Lin S, Terahara N, Wakamatsu M, Fujii M, Young MR, and Colburn N (2003) Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. Carcinogenesis 25:29-36.
12. Hung KY, Chen CT, Huang JW, Lee PH, Tsai TJ, and Hsieh BS (2001) Dipyridamole inhibits TGF-beta-induced collagen gene expression in human peritoneal mesothelial cells. Kidney Int 60:1249-1257.
13. Johnson GL and Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science (Wash DC) 298:1911-1912.
14. Kiely B, Feldman G, and Ryan MP (2003) Modulation of renal epithelial barrier function by mitogen-activated protein kinases (MAPKs): mechanism of cyclosporine A-induced increase in transepithelial resistance. Kidney Int 63:908-916.
15. Klahr S and Morrissey J (2002) Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 283:F861-F875.
16. Krogh P, Axelsen NH, Elling F, Gyrd-Hansen N, Hald B, Hyldgaard-Jensen J, Larsen AE, Madsen A, Mortensen HP, Moller T, et al. (1974) Experimental porcine nephropathy: changes of renal function and structure induced by ochratoxin A-contaminated feed. Acta Pathol Microbiol Scand (Suppl 246):1-21.
17. Krug AW, Schuster C, Gassner B, Freudinger R, Mildenberger S, Troppmair J, and Gekle M (2002) Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling. J Biol Chem 277:45892-45897.
18. Lentsch AB and Ward PA (2000) The NFkappaBb/IkappaB system in acute inflammation. Arch Immunol Ther Exp (Warsz) 48:59-63.
19. Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, and Lan HY (2002) Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13:1464-1472.
20. Liu Y (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism and therapeutic intervention. J Am Soc Nephrol 15:1-12.
21. Masszi A, Di Ciano C, Sirokmany G, Arthur WT, Rotstein OD, Wang J, McCulloch CA, Rosivall L, Mucsi I, and Kapus A (2003) Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 284:F911-F924.
22. Montesano R, Soriano JV, Hosseini G, Pepper MS, and Schramek H (1999) Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells. Cell Growth Differ 10:317-332.
23. Oka H, Chatani Y, Hoshino R, Ogawa O, Kakehi Y, Terachi T, Okada Y, Kawaichi M, Kohno M, and Yoshida O (1995) Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res 55:4182-4187.
24. Petzinger E and Ziegler K (2000) Ochratoxin A from a toxicological perspective. J Vet Pharmacol Ther 23:91-98.
25. Pfohl-Leszkowicz A, Petkova-Bocharova T, Chernozemsky IN, and Castegnaro M (2002) Balkan endemic nephropathy and associated urinary tract tumours: a review on etiological causes and the potential role of mycotoxins. Food Addit Contam 19:282-302.
26. Remuzzi G and Bertani T (1998) Pathophysiology of progressive nephropathies. N Engl J Med 339:1448-1456.
27. Rodriguez-Barbero A (1989) NTP Technical Report on the Toxicology and Carcinogenesis Studies on Ochratoxin A (CAS No. 303-47-8) in F334/N Rats (Gavage Studies), U.S. Department of Health and Human Services, Research Triangle Park, NC.
28. Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, and Yue W (2002) The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol 80:239-256.
29. Sauvant C, Holzinger H, and Gekle M (2004) Exposure to nephrotoxic Ochratoxin A enhances collagen secretion in human renal proximal tubular cells. Mol Nutr Food Res 49:31-37.
30. Sauvant C, Holzinger H, and Gekle M (2005) The nephrotoxin Ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cell Physiol Biochem 15:125-134.
31. Sauvant C, Silbernagl S, and Gekle M (1998) Exposure to ochratoxin A impairs organic anion transport in proximal tubule-derived opossum kidney cells. J Pharmacol Exp Ther 287:13-20.
32. Schlatter C, Studer-Rohr J, and Rasonyi T (1996) Carcinogenicity and kinetic aspects of ochratoxin A. Food Addit Contam 13 (Suppl 43):43-44.
33. Schwerdt G, Freudinger R, Mildenberger S, Silbernagl S, and Gekle M (1999) The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biol Toxicol 15:405-415.
34. Stambe C, Atkins RC, Hill PA, and Nikolic-Paterson DJ (2003) Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. Kidney Int 64:2121-2132.
35. Tian W, Zhang Z, and Cohen DM (2001) MAPK signaling and the kidney. Am J Physiol Renal Physiol 279:F593-F604.
36. Vrabcheva T, Petkova-Bocharova T, Grosso F, Nikolov I, Chernozemsky IN, Castegnaro M, and Dragacci S (2004) Analysis of ochratoxin A in foods consumed by inhabitants from an area with Balkan endemic nephropathy: a 1 month follow-up study. J Agric Food Chem 52:2404-2410.
37. Walker R (2002) Risk assessment of ochratoxin: current views of the European Scientific Committee on Food, the JECFA and the Codex Committee on Food Additives and Contaminants. Adv Exp Med Biol 504:249-255.
38. Wang Y, Li XM, and Wang HY (2002) IL-1beta stimulates alpha-smooth muscle actin expression through JNK/p38 signal pathway in cultured rat mesangial cells. Sheng Li Xue Bao 54:244-250.
39. Yang J and Liu Y (2001) Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159:1465-1475.
40. Yoshida K, Kuwano K, Hagimoto N, Watanabe K, Matsuba T, Fujita M, Inoshima I, and Kara N (2002) MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis. J Pathol 198:388-396.