-
1
-
-
0030956626
-
Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase
-
Wang H., Iynedjian P.B. Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. P. Natl. Acad. Sci. USA 1997, 94:4372-4377.
-
(1997)
P. Natl. Acad. Sci. USA
, vol.94
, pp. 4372-4377
-
-
Wang, H.1
Iynedjian, P.B.2
-
2
-
-
12344252712
-
Diagnosis and management of maturity-onset diabetes of the young Treat
-
Timsit J., Bellanne-Chantelot C., Dubois-Laforgue D., Velho G. Diagnosis and management of maturity-onset diabetes of the young Treat. Endocrinology 2005, 4:9-18.
-
(2005)
Endocrinology
, vol.4
, pp. 9-18
-
-
Timsit, J.1
Bellanne-Chantelot, C.2
Dubois-Laforgue, D.3
Velho, G.4
-
3
-
-
0029417331
-
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose
-
Terauchi Y., Sakura H., Yasuda K., Iwamoto K., Takahashi N., Ito K., Kasai H., Suzuki H., Ueda O., Kamada N. Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J. Biol. Chem. 1995, 270:30253-30256.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30253-30256
-
-
Terauchi, Y.1
Sakura, H.2
Yasuda, K.3
Iwamoto, K.4
Takahashi, N.5
Ito, K.6
Kasai, H.7
Suzuki, H.8
Ueda, O.9
Kamada, N.10
-
4
-
-
0028826361
-
Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis
-
Grupe A., Hultgren B., Ryan A., Ma Y.H., Bauer M., Stewart T.A. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 1995, 83:69-78.
-
(1995)
Cell
, vol.83
, pp. 69-78
-
-
Grupe, A.1
Hultgren, B.2
Ryan, A.3
Ma, Y.H.4
Bauer, M.5
Stewart, T.A.6
-
5
-
-
0031019249
-
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
-
Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M.F., Surwit R.S., Ricquier D., Warden C.H. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 1997, 15:269-272.
-
(1997)
Nat. Genet.
, vol.15
, pp. 269-272
-
-
Fleury, C.1
Neverova, M.2
Collins, S.3
Raimbault, S.4
Champigny, O.5
Levi-Meyrueis, C.6
Bouillaud, F.7
Seldin, M.F.8
Surwit, R.S.9
Ricquier, D.10
Warden, C.H.11
-
7
-
-
0034883804
-
Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes
-
Dalgaard L.T., Pedersen O. Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Diabetology 2001, 44:946-965.
-
(2001)
Diabetology
, vol.44
, pp. 946-965
-
-
Dalgaard, L.T.1
Pedersen, O.2
-
8
-
-
0033605261
-
Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
-
Chavin K.D., Yang S., Lin H.Z., Chatham J., Chacko V.P., Hoek J.B., Walajtys-Rode E., Rashid A., Chen C.H., Huang C.C., Wu T.C., Lane M.D., Diehl A.M. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem. 1999, 274:5692-5700.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5692-5700
-
-
Chavin, K.D.1
Yang, S.2
Lin, H.Z.3
Chatham, J.4
Chacko, V.P.5
Hoek, J.B.6
Walajtys-Rode, E.7
Rashid, A.8
Chen, C.H.9
Huang, C.C.10
Wu, T.C.11
Lane, M.D.12
Diehl, A.M.13
-
9
-
-
0037039366
-
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
-
Krauss S., Zhang C.Y., Lowell B.B. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. P. Natl. Acad. Sci. USA 2002, 99:118-122.
-
(2002)
P. Natl. Acad. Sci. USA
, vol.99
, pp. 118-122
-
-
Krauss, S.1
Zhang, C.Y.2
Lowell, B.B.3
-
10
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion is a major link between obesity beta cell dysfunction and type 2 diabetes
-
Zhang C.Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., Hagen T., Vidal-Puig A.J., Boss O., Kim Y.B., Zheng X.X., Wheeler M.B., Shulman G.I., Chan C.B., Lowell B.B. Uncoupling protein-2 negatively regulates insulin secretion is a major link between obesity beta cell dysfunction and type 2 diabetes. Cell 2001, 105:745-755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
11
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
-
Krauss S., Zhang C.Y., Scorrano L., Dalgaard L.T., St Pierre J., Grey S.T., Lowell B.B. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J. Clin. Invest. 2003, 112:1831-1842.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
Dalgaard, L.T.4
St Pierre, J.5
Grey, S.T.6
Lowell, B.B.7
-
12
-
-
10944265062
-
Free fatty acid induced beta -cell defects are dependent on uncoupling protein 2 expression
-
Joseph J.W., Koshkin V., Saleh M.C., Sivitz W.I., Zhang C.Y., Lowell B.B., Chan C.B., Wheeler M.B. Free fatty acid induced beta -cell defects are dependent on uncoupling protein 2 expression. J. Biol. Chem. 2004, 279:51049-51056.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51049-51056
-
-
Joseph, J.W.1
Koshkin, V.2
Saleh, M.C.3
Sivitz, W.I.4
Zhang, C.Y.5
Lowell, B.B.6
Chan, C.B.7
Wheeler, M.B.8
-
13
-
-
0037160091
-
Topology of superoxide production from different sites in the mitochondrial electron transport chain
-
St Pierre J., Buckingham J.A., Roebuck S.J., Brand M.D. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 2002, 277:44784-44790.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44784-44790
-
-
St Pierre, J.1
Buckingham, J.A.2
Roebuck, S.J.3
Brand, M.D.4
-
14
-
-
0346814090
-
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone
-
Murphy M.P., Echtay K.S., Blaikie F.H., Asin-Cayuela J., Cocheme H.M., Green K., Buckingham J.A., Taylor E.R., Hurrell F., Hughes G., Miwa S., Cooper C.E., Svistunenko D.A., Smith R.A., Brand M.D. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J. Biol. Chem. 2003, 278:48534-48545.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48534-48545
-
-
Murphy, M.P.1
Echtay, K.S.2
Blaikie, F.H.3
Asin-Cayuela, J.4
Cocheme, H.M.5
Green, K.6
Buckingham, J.A.7
Taylor, E.R.8
Hurrell, F.9
Hughes, G.10
Miwa, S.11
Cooper, C.E.12
Svistunenko, D.A.13
Smith, R.A.14
Brand, M.D.15
-
15
-
-
0041465009
-
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
-
Echtay K.S., Esteves T.C., Pakay J.L., Jekabsons M.B., Lambert A.J., Portero-Otin M., Pamplona R., Vidal-Puig A.J., Wang S., Roebuck S.J., Brand M.D. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003, 22:4103-4110.
-
(2003)
EMBO J.
, vol.22
, pp. 4103-4110
-
-
Echtay, K.S.1
Esteves, T.C.2
Pakay, J.L.3
Jekabsons, M.B.4
Lambert, A.J.5
Portero-Otin, M.6
Pamplona, R.7
Vidal-Puig, A.J.8
Wang, S.9
Roebuck, S.J.10
Brand, M.D.11
-
16
-
-
0346788896
-
Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling
-
Miwa S., Brand M.D. Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Biochem. Soc. Trans. 2003, 31:1300-1301.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 1300-1301
-
-
Miwa, S.1
Brand, M.D.2
-
17
-
-
25144476923
-
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
-
Brand M.D., Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005, 2:85-93.
-
(2005)
Cell Metab.
, vol.2
, pp. 85-93
-
-
Brand, M.D.1
Esteves, T.C.2
-
18
-
-
23244454768
-
The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3
-
Esteves T.C., Brand M.D. The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochem. Biophys. Acta 2005, 1709:35-44.
-
(2005)
Biochem. Biophys. Acta
, vol.1709
, pp. 35-44
-
-
Esteves, T.C.1
Brand, M.D.2
-
19
-
-
0037181143
-
Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets
-
Brown J.E., Thomas S., Digby J.E., Dunmore S.J. Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets. FEBS Lett. 2002, 513:189-192.
-
(2002)
FEBS Lett.
, vol.513
, pp. 189-192
-
-
Brown, J.E.1
Thomas, S.2
Digby, J.E.3
Dunmore, S.J.4
-
20
-
-
0036724133
-
Role of ATP-production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition
-
Patane G., Anello M., Piro S., Vigneri R., Purrello F., Rabuazzo A.M. Role of ATP-production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 2002, 51:2749-2756.
-
(2002)
Diabetes
, vol.51
, pp. 2749-2756
-
-
Patane, G.1
Anello, M.2
Piro, S.3
Vigneri, R.4
Purrello, F.5
Rabuazzo, A.M.6
-
21
-
-
0036829870
-
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
-
Joseph J.W., Koshkin V., Zhang C.Y., Wang J., Lowell B.B., Chan C.B., Wheeler M.B. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 2002, 51:3211-3219.
-
(2002)
Diabetes
, vol.51
, pp. 3211-3219
-
-
Joseph, J.W.1
Koshkin, V.2
Zhang, C.Y.3
Wang, J.4
Lowell, B.B.5
Chan, C.B.6
Wheeler, M.B.7
-
22
-
-
0037044822
-
Regulation of the uncoupling Protein-2 gene in INS-1 beta-cells by oleic acid
-
Medvedev A.V., Robidoux J., Bai X., Cao W., Floering L.M., Daniel K.W., Collins S. Regulation of the uncoupling Protein-2 gene in INS-1 beta-cells by oleic acid. J. Biol. Chem. 2002, 277:42639-42644.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42639-42644
-
-
Medvedev, A.V.1
Robidoux, J.2
Bai, X.3
Cao, W.4
Floering, L.M.5
Daniel, K.W.6
Collins, S.7
-
23
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan K.A., Grimm A.A., Plueger M.M., Bernal-Mizrachi E., Ford E., Cras-Meneur C., Permutt M.A., Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2005, 2:105-117.
-
(2005)
Cell Metab.
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Meneur, C.6
Permutt, M.A.7
Imai, S.8
-
24
-
-
0034006587
-
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
-
Hohmeier H.E., Mulder H., Chen G., Henkel-Rieger R., Prentki M., Newgard C.B. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 2000, 49:424-430.
-
(2000)
Diabetes
, vol.49
, pp. 424-430
-
-
Hohmeier, H.E.1
Mulder, H.2
Chen, G.3
Henkel-Rieger, R.4
Prentki, M.5
Newgard, C.B.6
-
25
-
-
0029922989
-
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger
-
Szabo C., Day B.J., Salzman A.L. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 1996, 38:82-86.
-
(1996)
FEBS Lett.
, vol.38
, pp. 82-86
-
-
Szabo, C.1
Day, B.J.2
Salzman, A.L.3
-
26
-
-
18244379331
-
Superoxide activates mitochondrial uncoupling proteins
-
Echtay K.S., Roussel D., St Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., Clapham J.C., Brand M.D. Superoxide activates mitochondrial uncoupling proteins. Nature 2002, 415:96-99.
-
(2002)
Nature
, vol.415
, pp. 96-99
-
-
Echtay, K.S.1
Roussel, D.2
St Pierre, J.3
Jekabsons, M.B.4
Cadenas, S.5
Stuart, J.A.6
Harper, J.A.7
Roebuck, S.J.8
Morrison, A.9
Pickering, S.10
Clapham, J.C.11
Brand, M.D.12
-
27
-
-
0032991716
-
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
-
Chan C.B., MacDonald P.E., Saleh M.C., Johns D.C., Marban E., Wheeler M.B. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 1999, 48:1482-1486.
-
(1999)
Diabetes
, vol.48
, pp. 1482-1486
-
-
Chan, C.B.1
MacDonald, P.E.2
Saleh, M.C.3
Johns, D.C.4
Marban, E.5
Wheeler, M.B.6
-
28
-
-
0031793554
-
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice
-
Sreenan S.K., Cockburn B.N., Baldwin A.C., Ostrega D.M., Levisetti M., Grupe A., Bell G.I., Stewart T.A., Roe M.W., Polonsky K.S. Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. Diabetes 1998, 47:1881-1888.
-
(1998)
Diabetes
, vol.47
, pp. 1881-1888
-
-
Sreenan, S.K.1
Cockburn, B.N.2
Baldwin, A.C.3
Ostrega, D.M.4
Levisetti, M.5
Grupe, A.6
Bell, G.I.7
Stewart, T.A.8
Roe, M.W.9
Polonsky, K.S.10
-
29
-
-
2242425423
-
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
-
Brand M.D., Pamplona R., Portero-Otin M., Requena J.R., Roebuck S.J., Buckingham J.A., Clapham J.C., Cadenas S. Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem. J. 2002, 368:597-603.
-
(2002)
Biochem. J.
, vol.368
, pp. 597-603
-
-
Brand, M.D.1
Pamplona, R.2
Portero-Otin, M.3
Requena, J.R.4
Roebuck, S.J.5
Buckingham, J.A.6
Clapham, J.C.7
Cadenas, S.8
-
30
-
-
0033669527
-
Beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes
-
Andrikopoulos S., Verchere C.B., Terauchi Y., Kadowaki T., Kahn S.E. Beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. Diabetes 2000, 49:2056-2062.
-
(2000)
Diabetes
, vol.49
, pp. 2056-2062
-
-
Andrikopoulos, S.1
Verchere, C.B.2
Terauchi, Y.3
Kadowaki, T.4
Kahn, S.E.5
-
31
-
-
0032584237
-
Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
-
Surwit R.S., Wang S., Petro A.E., Sanchis D., Raimbault S., Ricquier D., Collins S. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. P. Natl. Acad. Sci. USA 1998, 95:4061-4065.
-
(1998)
P. Natl. Acad. Sci. USA
, vol.95
, pp. 4061-4065
-
-
Surwit, R.S.1
Wang, S.2
Petro, A.E.3
Sanchis, D.4
Raimbault, S.5
Ricquier, D.6
Collins, S.7
-
32
-
-
67649641804
-
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
-
Pi J., Bai Y., Daniel K.W., Liu D., Lyght O., Edelstein D., Brownlee M., Corkey B.E., Collins S. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 2009, 150:3040-3048.
-
(2009)
Endocrinology
, vol.150
, pp. 3040-3048
-
-
Pi, J.1
Bai, Y.2
Daniel, K.W.3
Liu, D.4
Lyght, O.5
Edelstein, D.6
Brownlee, M.7
Corkey, B.E.8
Collins, S.9
-
33
-
-
52949094588
-
Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells
-
Azzu V., Affourtit C., Breen E.P., Parker N., Brand M.D. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochem. Biophys. Acta 2008, 1777:1378-1383.
-
(2008)
Biochem. Biophys. Acta
, vol.1777
, pp. 1378-1383
-
-
Azzu, V.1
Affourtit, C.2
Breen, E.P.3
Parker, N.4
Brand, M.D.5
|