Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation

Journal of Vascular Research

Volumn 49, Issue 2, 2012, Pages 89-100

  Beeson, Craig C ^b   Beeson, Gyda C ^b   Buff, Haley ^a   Eldridge, Juanita ^a   Zhang, Aiguo ^d   Seth, Arun ^d   Demcheva, Marina ^c   Vournakis, John N ^c   Muise Helmericks, Robin C ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c Marine Polymer Technologies Inc   (United States)

^d Institute of Clinical Evaluative Sciences   (Canada)

Author keywords

Akt1 gene; Angiogenesis; Fatty acid oxidation; Integrin; Oxygen consumption; Peroxisome proliferator activated receptor coactivator 1

Indexed keywords

ETOMOXIR; FATTY ACID; INTEGRIN; N ACETYLGLUCOSAMINE; NANOFIBER; PALMITIC ACID DERIVATIVE; PALMITIC ACID H 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN AKT1; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE KINASE 4; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BIOGENESIS; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENERGY YIELD; ENZYME ACTIVITY; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ACETYLGLUCOSAMINE; CARNITINE O-PALMITOYLTRANSFERASE; EPOXY COMPOUNDS; FATTY ACIDS; HEAT-SHOCK PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIA; NANOFIBERS; OXIDATION-REDUCTION; PPAR GAMMA; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84855817733     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000332326     Document Type: Article

References (52)

1. Singer AJ, Clark RA: Cutaneous wound healing. N Engl J Med 1999; 341: 738-746. (Pubitemid 29407375)
2. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, Bunting S, Steinmetz HG, Gurtner GC: Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004; 164: 1935-1947. (Pubitemid 38669343)
3. Hong YK, Lange-Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M: VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J 2004; 18: 1111-1113. (Pubitemid 39561540)
4. Tonnesen MG, Feng X, Clark RA: Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000; 5: 40-46. (Pubitemid 32044088)
5. Madeddu P: Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Exp Physiol 2005; 90: 315-326.
6. Yla-Herttuala S, Markkanen JE, Rissanen TT: Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials. Trends Cardiovasc Med 2004; 14: 295-300. (Pubitemid 41110607)
7. Katsube K, Bishop AT, Simari RD, Yla-Herttuala S, Friedrich PF: Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone. J Orthop Res 2005; 23: 469-474. (Pubitemid 40287877)
8. Hirsch JA, Reddy SA, Capasso WE, Linfante I: Non-invasive hemostatic closure devices: 'Patches and pads'. Tech Vasc Interv Radiol 2003; 6: 92-95. (Pubitemid 36950952)
9. Palmer BL, Gantt DS, Lawrence ME, Rajab MH, Dehmer GJ: Effectiveness and safety of manual hemostasis facilitated by the syvekpatch with one hour of bedrest after coronary angiography using six-french catheters. Am J Cardiol 2004; 93: 96-97. (Pubitemid 38022044)
10. Thatte HS, Zagarins S, Khuri SF, Fischer TH: Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions. J Trauma 2004; 57:S13-S21. (Pubitemid 39079212)
11. Fischer TH, Thatte HS, Nichols TC, Bender- Neal DE, Bellinger AD, Vournakis JN: Synergistic platelet integrin signaling and factor xii activation in poly-N-acetyl glucosamine fiber-mediated hemostasis. Biomaterials 2005; 26: 5433-5443. (Pubitemid 40592133)
12. Pietramaggiori G, Yang HJ, Scherer SS, Kaipainen A, Chan RK, Alperovich M, Newalder J, Demcheva M, Vournakis JN, Valeri CR, Hechtman HB, Orgill DP: Effects of poly-N-acetyl glucosamine (PGLCNAC) patch on wound healing in db/db mouse. J Trauma 2008; 64: 803-808. (Pubitemid 351366913)
13. Scherer SS, Pietramaggiori G, Matthews J, Perry S, Assmann A, Carothers A, Demcheva M, Muise-Helmericks RC, Seth A, Vournakis JN, Valeri RC, Fischer TH, Hechtman HB, Orgill DP: Poly-N-acetyl glucosamine nano-fibers: a new bioactive material to enhance diabetic wound healing by cell migration and angiogenesis. Ann Surg 2009; 250: 322-330.
14. Vournakis JN, Eldridge J, Demcheva M, Muise-Helmericks RC: Poly-N-acetyl glucosamine nanofibers regulate endothelial cell movement and angiogenesis: dependency on integrin activation of Ets1. J Vasc Res 2008; 45: 222-232. (Pubitemid 351543146)
15. Lin J, Handschin C, Spiegelman BM: Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005; 1: 361-370. (Pubitemid 43960626)
16. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267-273. (Pubitemid 36792858)
17. Puigserver P, Spiegelman BM: Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003; 24: 78-90. (Pubitemid 36223280)
18. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP: Peroxisome proliferator- activated receptor gamma coactivator- 1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000; 106: 847-856.
19. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002; 418: 797-801.
20. Kelly DP, Scarpulla RC: Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004; 18: 357-368. (Pubitemid 38316342)
21. Ojuka EO: Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and glut4 levels in muscle. Proc Nutr Soc 2004; 63: 275-278.
22. Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RS: Regulation of mitochondrial biogenesis in skeletal muscle by CAMK. Science 2002; 296: 349-352. (Pubitemid 34303690)
23. Barger PM, Browning AC, Garner AN, Kelly DP: P38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 2001; 276: 44495-44501.
24. Nemoto S, Fergusson MM, Finkel T: SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC- 1{alpha}. J Biol Chem 2005; 280: 16456-16460. (Pubitemid 40616776)
25. Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC: VEGF stimulation of mitochondrial biogenesis: requirement of Akt3 kinase. FASEB J 2008.
26. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S: Phosphoinositide-3- OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/ Akt by the integrin-linked kinase. Proc Natl Acad Sci USA 1998; 95: 11211-11216. (Pubitemid 28450107)
27. Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA: Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. J Biol Chem 2005; 280: 26630-26639. (Pubitemid 41022261)
28. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S: Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 2000; 97: 3207-3212. (Pubitemid 30183280)
29. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA: Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem 2006; 281: 39897-39906. (Pubitemid 46041793)
30. Connaughton S, Chowdhury F, Attia RR, Song S, Zhang Y, Elam MB, Cook GA, Park EA: Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin. Mol Cell Endocrinol 2010; 315: 159-167.
31. King DR, Cohn SM, Proctor KG: Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries. J Trauma 2004; 57: 756-759. (Pubitemid 39431196)
32. Fischer TH, Valeri CR, Smith CJ, Scull CM, Merricks EP, Nichols TC, Demcheva M, Vournakis JN: Non-classical processes in surface hemostasis: mechanisms for the poly-N-acetyl glucosamine-induced alteration of red blood cell morphology and surface prothrombogenicity. Biomed Mater 2008; 3: 15009.
33. Lavenburg KR, Ivey J, Hsu T, Muise-Helmericks RC: Coordinated functions of Akt/PKB and Ets1 in tubule formation. FASEB J 2003; 17: 2278-2280. (Pubitemid 39561465)
34. Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A: Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 2003; 52: 642-649. (Pubitemid 36323569)
35. Woods A, Couchman JR: Syndecans: synergistic activators of cell adhesion. Trends Cell Biol 1998; 8: 189-192. (Pubitemid 28188112)
36. Du K, Montminy M: CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 1998; 273: 32377-32379. (Pubitemid 28557606)
37. Somanath PR, Kandel ES, Hay N, Byzova TV: Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem 2007; 282: 22964-22976. (Pubitemid 47267339)
38. Mahabeleshwar GH, Byzova TV: Vascular integrin signaling. Methods Enzymol 2008; 443: 199-226.
39. Somanath PR, Chen J, Byzova TV: Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis 2008; 11: 277-288.
40. Werner E, Werb Z: Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol 2002; 158: 357-368.
41. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ: Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005; 436: 123-127. (Pubitemid 40966197)
42. Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem 2006; 281: 36443-36453. (Pubitemid 46041378)
43. Welch H, Eguinoa A, Stephens LR, Hawkins PT: Protein kinase B and Rac are activated in parallel within a phosphatidylinositide 3oh-kinase- controlled signaling pathway. J Biol Chem 1998; 273: 11248-11256. (Pubitemid 28204977)
44. Kim EK, Tucker DF, Yun SJ, Do KH, Kim MS, Kim JH, Kim CD, Birnbaum MJ, Bae SS: Linker region of Akt1/protein kinase Balpha mediates platelet-derived growth factor-induced translocation and cell migration. Cell Signal 2008; 20: 2030-2037.
45. Coffer PJ, Jin J, Woodgett JR: Protein kinase B (C-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998; 335: 1-13. (Pubitemid 28477043)
46. Chan TO, Rittenhouse SE, Tsichlis PN: Akt/ PKB and other d3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 1999; 68: 965-1014. (Pubitemid 29449213)
47. Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M: Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 2001; 20: 4419-4423. (Pubitemid 32726886)
48. Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N: Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 2003; 17: 1352-1365. (Pubitemid 36666005)
49. Chin YR, Toker A: Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin. Cell Adh Migrat 2011; 5: 211-214.
50. Hay N: Akt isoforms and glucose homeostasis - the leptin connection. Trends Endocrinol Metab 2011; 22: 66-73.
51. Gonzalez E, McGraw TE: The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 2009; 8: 2502-2508.
52. Li X, Monks B, Ge Q, Birnbaum MJ: Akt/ PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007; 447: 1012-1016. (Pubitemid 46975750)