Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries

Journal of Trauma - Injury, Infection and Critical Care

Volumn 57, Issue 4, 2004, Pages 756-759

  King, David R ^a   Cohn, Stephen M ^a,b   Proctor, Kenneth G ^a   Augenstein, Jeffrey ^a   Benjamin, Robert E ^a   Blackbourne, Lourne H ^a   Ginzburg, Enrique ^a   Lopez, Peter P ^a   Lynn, Mauricio ^a   Namias, Nicholas ^a   Pizano, Louis R ^a   Shatz, David ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

Acidosis; Hemostasis; Hypothermia; Liver; MRDH; RDH; Trauma

Indexed keywords

ACIDOSIS; ADULT; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD VESSEL INJURY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; HEMOSTASIS; HUMAN; HYPOTHERMIA; LIVER INJURY; PRIORITY JOURNAL; TREATMENT OUTCOME; WOUND DRESSING;

EID: 7244234579     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TA.0000147501.64610.AFS     Document Type: Article

References (21)

1. Hoyt DB, Bulger EM, Knudson MM, et al. Death in the operating room: an analysis of a multi-center experience. J Trauma. 1994;37:426-432.
2. Ong AW, Cohn SM. Trauma of the liver. In: Schiff E, Sorrell M, Maddrey W, eds. Schiff's Diseases of the Liver 9th ed. Baltimore: Lippincott Williams & Wilkins, 2002;1341-1350.
3. Pachter HL, Liang HG, Hofstetter SR. Liver and biliary tract trauma. In: Feliciano DV, Moore EE, Mattox KL, eds. Trauma. 3rd ed. Stamford, CN: Appleton and Lange, 1996;487-523.
4. Moore EE, Cogbill TH, Jurkovich GJ, Shackford SR, Malangoni MA, Champion HR. Organ injury scaling: spleen and liver (1994 revision). J Trauma. 1995;38:323-324.
5. Pusateri AE, Modrow HE, Harris RA, et al. Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine. J Trauma. 2003;55:518-526.
6. Jewelewicz DD, Cohn SM, Crookes BA, Proctor KG. Modified rapid deployment hemostat bandage reduces blood loss and mortality in coagulopathic pigs with severe liver injury. J Trauma. 2003;55:275-280; discussion 280-281. Erratum in J Trauma. 2003; 55:621.
7. Vournakis JN, Demcheva M, Whitson AB, Finkielsztein S, Connolly RJ. The RDH bandage: hemostasis and survival in a lethal aortotomy hemorrhage model. J Surg Res. 2003;113:1-5.
8. Chan MW, Schwaitzberg SD, Demcheva M, Vournakis J, Finkielsztein S, Connolly RJ. Comparison of poly-N-acetyl glucosamine (P-GlcNAc) with absorbable collagen (Actifoam), and fibrin sealant (Bolheal) for achieving hemostasis in a swine model of splenic hemorrhage. J Trauma. 2000;48:454-457.
9. Cole DJ, Connolly RJ, Chan MW, et al. A pilot study evaluating the efficacy of a fully acetylated poly-N-acetyl glucosamine membrane formulation as a topical hemostatic agent. Surgery. 1999;126:510-517.
10. Hirsch JA. Harvard symposium on the clinical efficacy and hemostatic mechanism of action of poly-N-acetyl glucosamine. J Invasive Cardiol 2003;15:1-4.
11. Vournakis J, Pariser ER, Finkielsztein S, et al. US Patent: #5,623,064 Poly-N-acetyl Glucosamine, issued April 22, 1997.
12. Kulling D, Woo S, Demcheva MV, Hawes RH, Vournakis JN. Poly-N-acetyl glucosamine: will it replace cyanoacrylate for treatment of gastric varices? A pilot study in a rabbit model. Endoscopy. 1998;30:S41-S42.
13. Kulling D, Vournakis JN, Woo S, et al. Endoscopic injection of bleeding esophageal varices with a poly-N-acetyl glucosamine gel formulation in the canine portal hypertension model. Gastrointest Endosc. 1999;49:764-771.
14. Nader RG, Garcia JC, Drushal K, Pesek T. Clinical evaluation of SyvekPatch in patients undergoing interventional, EPS and diagnostic cardiac catheterization procedures. J Invasive Cardiol. 2002;14:305-307.
15. Klokkevold PR, Fukayama H, Sung EC, Bertolami CN. The effect of chitosan (poly- N-acetyl glucosamine) on lingual hemostasis in heparinized rabbits. J Oral Maxillofac Surg. 1999;57:49-52.
16. Ikeda Y, Young LH, Vournakis JN, Lefer AM. Vascular effects of poly-N- acetylglucosamine in isolated rat aortic rings. J Surg Res. 2002;102:215-220.
17. Alam HB, Uy GB, Miller D, et al. Comparative analysis of hemostatic agents in a swine model of lethal groin injury. J Trauma. 2003;54(6):1077-82.
18. Tharanathan N, Kittur S. Chitin-the undisputed biomolecule of great potential. Critical Reviews in Food Science and Nutrition. 2003;43:61-87.
19. Thatte HS, Zagarins SE, Amiji, M, Khuri SF. Mechanisms of poly-N-acetyl glucosamine-mediated hemostasis: red blood cell interactions. Harvard Symposium on Clinical Activity and Mode of Action of the Hemostatic Agent Poly-N-Acetyl Glucosamine, February 25, 2003.
20. Vournakis JN, Demcheva, M, Whitson, A, Guirca, R, Pariser, ER. Isolation, purification and characterization of poly-N-acetyl glucosamine for use as hemostatic agent. Harvard Symposium on Clinical Activity and Mode of Action of the Hemostatic Agent Poly-N-Acetyl Glucosamine, February 25, 2003.
21. Vournakis JN, Finkielsztein S, Pariser ER, Helton M. Methods and Compositions for Poly-_-1-→4-N-Acetylglucosamine Biological Barriers. US Patent 5. 1997;624:679.