p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage

Protein and Cell

Volumn 1, Issue 6, 2010, Pages 573-583

  Wu, Chia Cheng ^a   Wu, Xiaohua ^a   Han, Jiahuai ^a,b   Sun, Peiqing ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b XIAMEN UNIVERSITY   (China)

Author keywords

checkpoint signaling; DNA damage; DNA repair; p38 ; UV

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DNA; HISTONE H2AX; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EMBRYO; ENZYME REGULATION; EXCISION REPAIR; GENE DELETION; HISTONE PHOSPHORYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION EXPOSURE; SENSITIZATION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

EUKARYOTA;

EID: 79953206965     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-010-0075-1     Document Type: Article

References (41)

1. Abraham, R. T. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15, 2177-2196.
2. Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., et al. (2005). Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol 25, 10454-10464.
3. Bomgarden, R. D., Lupardus, P. J., Soni, D. V., Yee, M. C., Ford, J. M., and Cimprich, K. A. (2006). Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J 25, 2605-2614.
4. Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., and Fornace, A. J. Jr. (2001). Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411, 102-107.
5. Bulavin, D. V., Saito, S., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., and Fornace, A. J. Jr. (1999). Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18, 6845-6854.
6. Cimprich, K. A., and Cortez, D. (2008). ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 9, 616-627.
7. Cline, S. D., and Hanawalt, P. C. (2003). Who's on first in the cellular response to DNA damage? Nat Rev Mol Cell Biol 4, 361-372.
8. Dent, P., Yacoub, A., Fisher, P. B., Hagan, M. P., and Grant, S. (2003). MAPK pathways in radiation responses. Oncogene 22, 5885-5896.
9. Enslen, H., Brancho, D. M., and Davis, R. J. (2000). Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO J 19, 1301-1311.
10. Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25, 115-119.
11. Han, J., Lee, J. D., Bibbs, L., and Ulevitch, R. J. (1994). A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811.
12. Han, J., and Sun, P. (2007). The pathways to tumor suppression via route p38. Trends Biochem Sci 32, 364-371.
13. Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D. A., Berger, M. S., and Pieper, R. O. (2003). The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol 23, 8306-8315.
14. Hu, W., Feng, Z., and Tang, M. S. (2004). Nickel (II) enhances benzo [a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis 25, 455-462.
15. Jia, L., Wang, X. W., and Harris, C. C. (1999). Hepatitis B virus X protein inhibits nucleotide excision repair. Int J Cancer 80, 875-879.
16. Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J. A., Lin, S., and Han, J. (1996). Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem 271, 17920-17926.
17. Jiang, Y., Gram, H., Zhao, M., New, L., Gu, J., Feng, L., Di Padova, F., Ulevitch, R. J., and Han, J. (1997). Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem 272, 30122-30128.
18. Johnson, G. L., and Lapadat, R. (2002). Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912.
19. Kang, Y. J., Chen, J., Otsuka, M., Mols, J., Ren, S., Wang, Y., and Han, J. (2008). Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol 180, 5075-5082.
20. Kastan, M. B., and Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature 432, 316-323.
21. Latonen, L., and Laiho, M. (2005). Cellular UV damage responses-functions of tumor suppressor p53. Biochim Biophys Acta 1755, 71-89.
22. Li, Z., Jiang, Y., Ulevitch, R. J., and Han, J. (1996). The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun 228, 334-340.
23. Lim, D. S., Kim, S. T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H., and Kastan, M. B. (2000). ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404, 613-617.
24. Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E., and Yaffe, M. B. (2005). MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell 17, 37-48.
25. Nebreda, A. R., and Porras, A. (2000). p38 MAP kinases: beyond the stress response. Trends Biochem Sci 25, 257-260.
26. Olson, E., Nievera, C. J., Lee, A. Y., Chen, L., and Wu, X. (2007). The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem 282, 22939-22952.
27. Ono, K., and Han, J. (2000). The p38 signal transduction pathway: activation and function. Cell Signal 12, 1-13.
28. Otsuka, M., Kang, Y. J., Ren, J., Jiang, H., Wang, Y., Omata, M., and Han, J. (2010). Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology 138, 1255-65, 1265.
29. Raman, M., Earnest, S., Zhang, K., Zhao, Y., and Cobb, M. H. (2007). TAO kinases mediate activation of p38 in response to DNA damage. EMBO J 26, 2005-2014.
30. Sabio, G., Arthur, J. S., Kuma, Y., Peggie, M., Carr, J., Murray-Tait, V., Centeno, F., Goedert, M., Morrice, N. A., and Cuenda, A. (2005). p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J 24, 1134-1145.
31. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
32. She, Q. B., Chen, N., and Dong, Z. (2000). ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 275, 20444-20449.
33. Shi, Y., and Gaestel, M. (2002). In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol Chem 383, 1519-1536.
34. Sun, P., Dong, P., Dai, K., Hannon, G. J., and Beach, D. (1998). p53-independent role of MDM2 in TGF-beta1 resistance. Science 282, 2270-2272.
35. Tanoue, T., Yamamoto, T., Maeda, R., and Nishida, E. (2001). A novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem 276, 26629-26639.
36. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C., and Abraham, R. T. (1999). A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13, 152-157.
37. van Attikum, H., and Gasser, S. M. (2009). Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol 19, 207-217.
38. Wang, X., McGowan, C. H., Zhao, M., He, L., Downey, J. S., Fearns, C., Wang, Y., Huang, S., and Han, J. (2000). Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol 20, 4543-4552.
39. Wu, X., Ranganathan, V., Weisman, D. S., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G., et al. (2000). ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 405, 477-482.
40. Zhao, Q., Barakat, B. M., Qin, S., Ray, A., El-Mahdy, M. A., Wani, G., Arafa, S., Mir, S. N., Wang, Q. E., and Wani, A. A. (2008). The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. J Biol Chem 283, 32553-32561.
41. Zhao, S., Weng, Y. C., Yuan, S. S., Lin, Y. T., Hsu, H. C., Lin, S. C., Gerbino, E., Song, M. H., Zdzienicka, M. Z., Gatti, R. A., et al. (2000). Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405, 473-477.