Rapid nongenomic effects of aldosterone on the renal vasculature in humans

Hypertension

Volumn 47, Issue 4, 2006, Pages 650-655

  Schmidt, Bernhard M W ^a   Sammer, Ulla ^a   Fleischmann, Ingrid ^a   Schlaich, Markus ^a   Delles, Christian ^a   Schmieder, Roland E ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Aldosterone; Glomerular filtration rate; Nitric oxide

Indexed keywords

ALDOSTERONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; N(G) METHYLARGININE; VASOCONSTRICTOR AGENT;

ADULT; ARTICLE; ENDOTHELIAL DYSFUNCTION; ENZYME INHIBITION; GLOMERULUS FILTRATION RATE; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; KIDNEY ARTERY; KIDNEY BLOOD FLOW; KIDNEY PLASMA FLOW; KIDNEY VASCULAR RESISTANCE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; BLOOD; BLOOD VESSEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; KIDNEY CIRCULATION; RANDOMIZED CONTROLLED TRIAL; TIME; VASCULAR RESISTANCE; VASCULARIZATION;

ADULT; ALDOSTERONE; BLOOD VESSELS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; GLOMERULAR FILTRATION RATE; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; OMEGA-N-METHYLARGININE; RENAL CIRCULATION; TIME FACTORS; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 33645838372     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000205224.58715.cc     Document Type: Article

References (28)

1. Lim PO, Rodgers P, Cardale K, Watson AD, MacDonald TM. Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet. 1999;353:40.
2. Schmidt BMW, Schmieder RE. Aldosterone-induced cardiac damage: focus on blood pressure independent effects. Am J Hypertens. 2003;16:80-86.
3. Hollenberg NK. Aldosterone in the development and progression of renal injury. Kidney Int. 2004;66:1-9.
4. Funder JW. Non-genomic actions of aldosterone: role in hypertension. Curr Opin Nephrol Hypertens. 2001;10:227-230.
5. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol Rev. 2000;52:513-556.
6. Schmidt BMW, Gerdes D, Feuring M, Falkenstein E, Christ M, Wehling M. Rapid, nongenomic steroid actions: A new age? Front Neuroendocrinol. 2000;21:57-94.
7. Wehling M, Spes CH, Win N, Janson CP, Schmidt BMW, Theisen K, Christ M. Rapid cardiovascular action of aldosterone in man. J Clin Endocrinol Metab. 1998;83:3517-3522.
8. Schmidt BMW, Montealegre A, Janson CP, Martin N, Stein-Kemmesies C, Scherhag A, Feuring M, Christ M, Wehling M. Short term cardiovascular effects of aldosterone in healthy male volunteers. J Clin Endocrinol Metab. 1999;84:3528-3533.
9. Schmidt BMW, Georgens AC, Martin N, Tillmann HC, Feuring M, Christ M, Wehling M. Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system. J Clin Endocrinol Metab. 2001;86:761-767.
10. Klein K, Henk W. Klinisch-experimentelle Untersuchungen über den Einfluβ von Aldosteron auf Hämodynamik und Gerinnung. Z Kreislaufforsch. 1963;52:40-53.
11. Schmidt BMW, Oehmer S, Delles C, Bratke R, Schneider MP, Klingbeil A, Fleischmann EH, Schmieder RE. Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension. 2003;42:156-160.
12. Gunaruwan P, Schmitt M, Sharman J, Lee L, Struthers A, Frenneaux M. Effects of aldosterone on forearm vasculature in treated chronic heart failure. Am J Cardiol. 2005;95:412-414.
13. Arima S, Kohagura K, Xu HL, Sugawara A, Abe T, Satoh F, Takeuchi K, Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol. 2003;14:2255-2263.
14. Arima S, Kohagura K, Xu HL, Sugawara A, Uruno A, Satoh F, Takeuchi K, Ito S. Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole. Hypertension. 2004;43:352-357.
15. Uhrenholt TR, Schjerning J, Hansen PB, Nonegaard R, Jensen BL, Sorensen GL, Skott O. Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone. Circ Res. 2003;93:1258-1266.
16. Liu SL, Schmuck S, Chorazcyzewski JZ, Gros R, Feldman RD. Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidyl-inositol 3-kinase-dependent nitric oxide synthase activation. Circulation. 2003;108:2400-2406.
17. Skov K, Mulvany MJ. Structure of renal afferent arterioles in the pathogenesis of hypertension. Acta Physiol Scand. 2004;181:397-405.
18. Matthews JN. Multi-period crossover trials. Stat Methods Med Res. 1994;3:383-405.
19. Schmieder RE, Veelken R, Schobel H, Dominiak P, Mann JF, Luft FC. Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension. J Am Soc Nephrol. 1997;8:893-900.
20. Gomez DM. Evaluation of renal resistances, with special reference to changes in essential hypertension. J Clin Invest. 1951;30:1143-1155.
21. Guidi E, Cozzi MG, Minetti EE, Civati G, Busnach G, Brando B. Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy. Am J Hypertens. 2001;14:121-128.
22. Delles C, Klingbeil AU, Schneider MP, Handrock R, Weidinger G, Schmieder RE. Direct comparison of the effects of valsartan and amlodipine on renal hemodynamics in human essential hypertension. Am J Hypertens. 2003;16:1030-1035.
23. Schmieder RE, Gatzka C, Schobel H, Schachinger H, Weihprecht H. Renal hemodynamic response to stress is influenced by ACE-inhibitors. Clin Nephrol. 1994;42:381-388.
24. Schneider M, Ulsenheimer A, Christ M, Wehling M. Nongenomic effects of aldosterone on intracellular calcium in porcine endothelial cells. Am J Physiol. 1997;272:E616-E620.
25. Delles C, Jacobi J, Schlaich MP, John S, Schmieder RE. Assessment of endothelial function of the renal vasculature in human subjects. Am J Hypertens. 2002;15:3-9.
26. Delles C, Jacobi J, John S, Fleischmann I, Schmieder RE. Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension 1. Kidney Int. 2002;61:1462-1468.
27. Uhrenholt TR, Schjerning J, Rasmussen LE, Hansen PB, Norregaard R, Jensen BL, Skott O. Rapid non-genomic effects of aldosterone on rodent vascular function. Acta Physiol Scand. 2004;181:415-419.
28. Michea L, Delpiano AM, Hitschfeld C, Lobos L, Lavandero S, Marusic ET. Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels and vasoconstriction in mesenteric resistance vessels. Endocrinology. 2004;146:973-980.