Drosophila as a genetic model for studying pathogenic human viruses

Virology

Volumn 423, Issue 1, 2012, Pages 1-5

  Hughes, Tamara T ^a   Allen, Amanda L ^a   Bardin, Joseph E ^a   Christian, Megan N ^a   Daimon, Kansei ^a   Dozier, Kelsey D ^a   Hansen, Caom L ^a   Holcomb, Lisa M ^a   Ahlander, Joseph ^a  

^a NORTHEASTERN STATE UNIVERSITY   (United States)

Author keywords

Drosophila; GAL4 UAS system; Human pathogens; Model organism; Transgenic expression; Viruses

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NEF PROTEIN; REV PROTEIN; TRANSCRIPTION FACTOR GAL4;

CONTROLLED STUDY; COPY NUMBER VARIATION; DENGUE VIRUS; DROSOPHILA MELANOGASTER; EPSTEIN BARR VIRUS; GENE EXPRESSION SYSTEM; GENE FUNCTION; GENETIC MODEL; HEPATITIS B VIRUS; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VIVO CULTURE; INFLUENZA VIRUS A; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SARS CORONAVIRUS; SHORT SURVEY; SIMIAN VIRUS 40; SINDBIS VIRUS; VESICULAR STOMATITIS VIRUS; VIRAL GENETICS; VIRUS CULTURE; VIRUS INFECTION; VIRUS PATHOGENESIS; VIRUS VIRULENCE; WEST NILE FLAVIVIRUS;

ANIMALS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; HUMANS; MODELS, GENETIC; VIRUS DISEASES; VIRUS PHYSIOLOGICAL PHENOMENA; VIRUSES;

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 84855352423     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.11.016     Document Type: Short Survey

References (59)

1. Adamson A.L., Wright N., LaJeunesse D.R. Modeling early Epstein-Barr virus infection in Drosophila melanogaster: the BZLF1 protein. Genetics 2005, 171:1125-1135.
2. Adamson A.L., Chohan K., Swenson J., Lajeunesse D.R. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics 2011, 189:495-506.
3. Asano M., Wharton R.P. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J. 1999, 18:2435-2448.
4. Avadhanula V., Weasner B.P., Hardy G.G., Kumar J.P., Hardy R.W. A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response. PLoS Pathog. 2009, 5:e1000582.
5. Battaglia P.A., Zito S., Macchini A., Gigliani F. A Drosophila model of HIV-Tat-related pathogenicity. J. Cell Sci. 2001, 114:2787-2794.
6. Brackney D.E., Scott J.C., Sagawa F., Woodward J.E., Miller N.A., Schilkey F.D., Mudge J., Wilusz J., Olson K.E., Blair C.D., Ebel G.D. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl. Trop. Dis. 2010, 4:e856.
7. Brighty D.W., Rosenberg M. A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs independently of known splice signals. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:8314-8318.
8. Butler T.R., Smith K.J., Self R.L., Braden B.B., Prendergast M.A. Neurodegenerative effects of recombinant HIV-1 Tat(1-86) are associated with inhibition of microtubule formation and oxidative stress-related reductions in microtubule-associated protein-2(a, b). Neurochem. Res. 2011, 36:819-828.
9. Cavener D.R. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Res. 1987, 15:1353-1361.
10. Chan H.Y., Tung C.K., O'Kane C.J. Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila. Genesis 2002, 34:139-141.
11. Chan C.M., Ma C.W., Chan W.Y., Chan H.Y. The SARS-coronavirus membrane protein induces apoptosis through modulating the Akt survival pathway. Arch. Biochem. Biophys. 2007, 459:197-207.
12. Chan C.M., Tsoi H., Chan W.M., Zhai S., Wong C.O., Yao X., Chan W.Y., Tsui S.K., Chan H.Y. The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function. Int. J. Biochem. Cell Biol. 2009, 41:2232-2239.
13. Chaudhuri R., Lindwasser O.W., Smith W.J., Hurley J.H., Bonifacino J.S. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J. Virol. 2007, 81:3877-3890.
14. Chen D., Wang M., Zhou S., Zhou Q. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. EMBO J. 2002, 21:6801-6810.
15. Chen C., Zhao B., Yang X., Li Y. Role of two-way airflow owing to temperature difference in severe acute respiratory syndrome transmission: revisiting the largest nosocomial severe acute respiratory syndrome outbreak in Hong Kong. J. R. Soc. Interface 2011, 8:699-710.
16. Cherepanov P., Maertens G.N., Hare S. Structural insights into the retroviral DNA integration apparatus. Curr. Opin. Struct. Biol. 2011, 21:249-256.
17. Cherry S. VSV infection is sensed by Drosophila, attenuates nutrient signaling, and thereby activates antiviral autophagy. Autophagy 2009, 5:1062-1063.
18. Chotkowski H.L., Ciota A.T., Jia Y., Puig-Basagoiti F., Kramer L.D., Shi P.Y., Glaser R.L. West Nile virus infection of Drosophila melanogaster induces a protective RNAi response. Virology 2008, 377:197-206.
19. Chou Y.T., Tam B., Linay F., Lai E.C. Transgenic inhibitors of RNA interference in Drosophila. Fly (Austin) 2007, 1:311-316.
20. Dimova D.K., Dyson N.J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005, 24:2810-2826.
21. Duffy J.B. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 2002, 34:1-15.
22. Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398.
23. Galiana-Arnoux D., Dostert C., Schneemann A., Hoffmann J.A., Imler J.L. Essential function in vivo for Dicer-2 in host defense against RNA viruses in Drosophila. Nat. Immunol. 2006, 7:590-597.
24. Garcia J.V., Miller A.D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 1991, 350:508-511.
25. Glaser R.L., Meola M.A. The native Wolbachia endosymbionts of Drosophila melanogaster and Culex quinquefasciatus increase host resistance to West Nile virus infection. PLoS One 2010, 5:e11977.
26. Hao L., Sakurai A., Watanabe T., Sorensen E., Nidom C.A., Newton M.A., Ahlquist P., Kawaoka Y. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 2008, 454:890-893.
27. Hong S.W., Qi W., Brabant M., Bosco G., Martinez J.D. Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster. Cell Div 2008, 3:2.
28. Ivey-Hoyle M., Rosenberg M. Rev-dependent expression of human immunodeficiency virus type 1 gp160 in Drosophila melanogaster cells. Mol. Cell. Biol. 1990, 10:6152-6159.
29. Kilmarx P.H. Global epidemiology of HIV. Curr. Opin. HIV AIDS 2009, 4:240-246.
30. Kotadia S., Kao L.R., Comerford S.A., Jones R.T., Hammer R.E., Megraw T.L. PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen. Oncogene 2008, 27:6334-6346.
31. Lam V.K., Tokusumi T., Cerabona D., Schulz R.A. Specific cell ablation in Drosophila using the toxic viral protein M2(H37A). Fly (Austin) 2010, 4:338-343.
32. Lee S.B., Park J., Jung J.U., Chung J. Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila. J. Cell Sci. 2005, 118:1851-1859.
33. Leulier F., Marchal C., Miletich I., Limbourg-Bouchon B., Benarous R., Lemaitre B. Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses. EMBO Rep. 2003, 4:976-981.
34. Li W.X., Li H., Lu R., Li F., Dus M., Atkinson P., Brydon E.W., Johnson K.L., Garcia-Sastre A., Ball L.A., Palese P., Ding S.W. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:1350-1355.
35. Moser T.S., Jones R.G., Thompson C.B., Coyne C.B., Cherry S. A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog. 2010, 6:e1000954.
36. Mudiganti U., Hernandez R., Ferreira D., Brown D.T. Sindbis virus infection of two model insect cell systems-a comparative study. Virus Res. 2006, 122:28-34.
37. Mudiganti U., Hernandez R., Brown D.T. Insect response to alphavirus infection-establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage. Virus Res. 2010, 150:73-84.
38. Mueller S., Gausson V., Vodovar N., Deddouche S., Troxler L., Perot J., Pfeffer S., Hoffmann J.A., Saleh M.C., Imler J.L. RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:19390-19395.
39. Mukherjee S., Hanley K.A. RNA interference modulates replication of dengue virus in Drosophila melanogaster cells. BMC Microbiol. 2010, 10:127.
40. Musselman L.P., Fink J.L., Narzinski K., Ramachandran P.V., Hathiramani S.S., Cagan R.L., Baranski T.J. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis. Model. Mech. 2011, 4:842-849.
41. NIH, 2011. NIH Guidelines for Research Involving Recombinant DNA Molecules, May ed, pp. III-D-4-a.
42. Padhan K., Minakshi R., Towheed M.A., Jameel S. Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation. J. Gen. Virol. 2008, 89:1960-1969.
43. Pfeiffer B.D., Ngo T.T., Hibbard K.L., Murphy C., Jenett A., Truman J.W., Rubin G.M. Refinement of tools for targeted gene expression in Drosophila. Genetics 2010, 186:735-755.
44. Ponti D., Troiano M., Bellenchi G.C., Battaglia P.A., Gigliani F. The HIV Tat protein affects processing of ribosomal RNA precursor. BMC Cell Biol. 2008, 9:32.
45. Read R.D., Goodfellow P.J., Mardis E.R., Novak N., Armstrong J.R., Cagan R.L. A Drosophila model of multiple endocrine neoplasia type 2. Genetics 2005, 171:1057-1081.
46. Reiter L.T., Potocki L., Chien S., Gribskov M., Bier E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001, 11:1114-1125.
47. Rose P.P., Hanna S.L., Spiridigliozzi A., Wannissorn N., Beiting D.P., Ross S.R., Hardy R.W., Bambina S.A., Heise M.T., Cherry S. Natural resistance-associated macrophage protein is a cellular receptor for Sindbis virus in both insect and mammalian hosts. Cell Host Microbe 2011, 10:97-104.
48. Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R., Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.H., Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D., Peret T.C., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R., Gunther S., Osterhaus A.D., Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003, 300:1394-1399.
49. Sabin L.R., Zhou R., Gruber J.J., Lukinova N., Bambina S., Berman A., Lau C.K., Thompson C.B., Cherry S. Ars2 regulates both miRNA- and siRNA-dependent silencing and suppresses RNA virus infection in Drosophila. Cell 2009, 138:340-351.
50. Sabin L.R., Hanna S.L., Cherry S. Innate antiviral immunity in Drosophila. Curr. Opin. Immunol. 2010, 22:4-9.
51. Saleh M.C., Tassetto M., van Rij R.P., Goic B., Gausson V., Berry B., Jacquier C., Antoniewski C., Andino R. Antiviral immunity in Drosophila requires systemic RNA interference spread. Nature 2009, 458:346-350.
52. Sessions O.M., Barrows N.J., Souza-Neto J.A., Robinson T.J., Hershey C.L., Rodgers M.A., Ramirez J.L., Dimopoulos G., Yang P.L., Pearson J.L., Garcia-Blanco M.A. Discovery of insect and human dengue virus host factors. Nature 2009, 458:1047-1050.
53. Shelly S., Lukinova N., Bambina S., Berman A., Cherry S. Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity 2009, 30:588-598.
54. Steinberg R., Shemer-Avni Y., Adler N., Neuman-Silberberg S. Human cytomegalovirus immediate-early-gene expression disrupts embryogenesis in transgenic Drosophila. Transgenic Res. 2008, 17:105-119.
55. Stockman L.J., Bellamy R., Garner P. SARS: systematic review of treatment effects. PLoS Med. 2006, 3:e343.
56. Wang H.D., Trivedi A., Johnson D.L. Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol. Cell. Biol. 1998, 18:7086-7094.
57. Welch M., Villalobos A., Gustafsson C., Minshull J. Designing genes for successful protein expression. Methods Enzymol. 2011, 498:43-66.
58. Wong S.L., Chen Y., Chan C.M., Chan C.S., Chan P.K., Chui Y.L., Fung K.P., Waye M.M., Tsui S.K., Chan H.Y. In vivo functional characterization of the SARS-coronavirus 3a protein in Drosophila. Biochem. Biophys. Res. Commun. 2005, 337:720-729.
59. Zhang J., Schulze K.L., Hiesinger P.R., Suyama K., Wang S., Fish M., Acar M., Hoskins R.A., Bellen H.J., Scott M.P. Thirty-one flavors of Drosophila rab proteins. Genetics 2007, 176:1307-1322.