메뉴 건너뛰기




Volumn 36, Issue 5, 2011, Pages 819-828

Neurodegenerative effects of recombinant HIV-1 Tat(1-86) are associated with inhibition of microtubule formation and oxidative stress-related reductions in microtubule-associated protein-2(a,b)

Author keywords

Acquired immune deficiency syndrome; Neurotoxicity; Trolox; Tubulin

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; PROPIDIUM IODIDE; TRANSACTIVATOR PROTEIN; TROLOX C; TUBULIN; VINCRISTINE SULFATE;

EID: 79954448574     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-011-0409-2     Document Type: Article
Times cited : (19)

References (54)
  • 1
    • 78149473179 scopus 로고    scopus 로고
    • ER-beta mediates 17 beta-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling
    • 20340172 10.1002/syn.20793 1:CAS:528:DC%2BC3cXhtFGqtbzF
    • SM Adams MV Aksenova MY Aksenov, et al. 2010 ER-beta mediates 17 beta-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling Synapse 64 11 829 838 20340172 10.1002/syn.20793 1:CAS:528:DC%2BC3cXhtFGqtbzF
    • (2010) Synapse , vol.64 , Issue.11 , pp. 829-838
    • Adams, S.M.1    Aksenova, M.V.2    Aksenov, M.Y.3
  • 2
    • 69749116487 scopus 로고    scopus 로고
    • Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cultures
    • 19615365 10.1016/j.expneurol.2009.07.005 1:CAS:528:DC%2BD1MXhtFajs7vK
    • MY Aksenov MV Aksenov CF Mactutus, et al. 2009 Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cultures Exp Neurol 219 586 590 19615365 10.1016/j.expneurol.2009.07.005 1:CAS:528: DC%2BD1MXhtFajs7vK
    • (2009) Exp Neurol , vol.219 , pp. 586-590
    • Aksenov, M.Y.1    Aksenov, M.V.2    MacTutus, C.F.3
  • 3
    • 32244441947 scopus 로고    scopus 로고
    • Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: The role of oxidative stress and D1 dopamine receptor
    • DOI 10.1016/j.neuro.2005.10.003, PII S0161813X05001816
    • MY Aksenov MV Aksenova A Nath, et al. 2006 Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: The role of oxidative stress and D1 dopamine receptor Neurotoxicology 27 217 228 16386305 10.1016/j.neuro.2005.10.003 1:CAS:528:DC%2BD28XhtlCksLk%3D (Pubitemid 43212830)
    • (2006) NeuroToxicology , vol.27 , Issue.2 , pp. 217-228
    • Aksenov, M.Y.1    Aksenova, M.V.2    Nath, A.3    Ray, P.D.4    Mactutus, C.F.5    Booze, R.M.6
  • 4
    • 0142011177 scopus 로고    scopus 로고
    • Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum
    • DOI 10.1016/S0006-8993(03)03194-9
    • MY Aksenov U Hasselrot G Wu, et al. 2003 Temporal relationships between HIV-1 Tat induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum Brain Res 987 1 1 9 14499939 10.1016/S0006-8993(03)03194-9 1:CAS:528:DC%2BD3sXnt1aru7s%3D (Pubitemid 37267880)
    • (2003) Brain Research , vol.987 , Issue.1 , pp. 1-9
    • Aksenov, M.Y.1    Hasselrot, U.2    Wu, G.3    Nath, A.4    Anderson, C.5    Mactutus, C.F.6    Booze, R.M.7
  • 5
    • 1642307513 scopus 로고    scopus 로고
    • A comparative study of the effect of oxidative stress on the cytoskeleton in human cortical neurons
    • DOI 10.1016/j.taap.2003.12.010, PII S0041008X03005696
    • PK Allani T Sum SG Bhansali, et al. 2004 Comparative study of the effect of oxidative stress on the cytoskeleton in human cortical neurons Toxicol Appl Pharmacol 196 29 36 15050405 10.1016/j.taap.2003.12.010 1:CAS:528: DC%2BD2cXisFyrs7c%3D (Pubitemid 38393691)
    • (2004) Toxicology and Applied Pharmacology , vol.196 , Issue.1 , pp. 29-36
    • Allani, P.K.1    Sum, T.2    Bhansali, S.G.3    Mukherjee, S.K.4    Sonee, M.5
  • 6
    • 33646104431 scopus 로고    scopus 로고
    • Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage
    • DOI 10.1523/JNEUROSCI.0603-06.2006
    • S Aprea L Del Valle G Mameli, et al. 2006 Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage J Neurosci 26 4054 4062 16611822 10.1523/JNEUROSCI.0603-06.2006 1:CAS:528:DC%2BD28XktFantb0%3D (Pubitemid 44315426)
    • (2006) Journal of Neuroscience , vol.26 , Issue.15 , pp. 4054-4062
    • Aprea, S.1    DeL Valle, L.2    Mameli, G.3    Sawaya, B.E.4    Khalili, K.5    Peruzzi, F.6
  • 8
    • 16244400107 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier to HIV-1 Tat
    • DOI 10.1016/j.expneurol.2004.11.019
    • WA Banks SM Robinson A Nath 2005 Permeability of the blood-brain barrier to HIV-1 Tat Exp Neurol 193 218 227 15817280 10.1016/j.expneurol.2004.11.019 1:CAS:528:DC%2BD2MXjtVyku7o%3D (Pubitemid 40463283)
    • (2005) Experimental Neurology , vol.193 , Issue.1 , pp. 218-227
    • Banks, W.A.1    Robinson, S.M.2    Nath, A.3
  • 9
    • 0035037852 scopus 로고    scopus 로고
    • Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: Role of envelope proteins and adsorptive endocytosis
    • DOI 10.1128/JVI.75.10.4681-4691.2001
    • WA Banks EO Freed KM Wolf, et al. 2001 Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis J Virol 75 4681 4691 11312339 10.1128/JVI.75.10.4681-4691.2001 1:STN:280:DC%2BD3M3it1ehsA%3D%3D (Pubitemid 32381510)
    • (2001) Journal of Virology , vol.75 , Issue.10 , pp. 4681-4691
    • Banks, W.A.1    Freed, E.O.2    Wolf, K.M.3    Robinson, S.M.4    Franko, M.5    Kumar, V.B.6
  • 10
    • 0034865342 scopus 로고    scopus 로고
    • A Drosophila model of HIV-tat-related pathogenicity
    • PA Battaglia S Zito A Macchini, et al. 2001 A Drosophila model of HIV-Tat related pathogenicity J Cell Sci 114 Pt 15 2787 2794 11683412 1:CAS:528:DC%2BD3MXmt1Wgu7s%3D (Pubitemid 32785457)
    • (2001) Journal of Cell Science , vol.114 , Issue.15 , pp. 2787-2794
    • Battaglia, P.A.1    Zito, S.2    Macchini, A.3    Gigliani, F.4
  • 11
    • 1642430703 scopus 로고    scopus 로고
    • Microtubule-targeted anticancer agents and apoptosis
    • DOI 10.1038/sj.onc.1207233, Apoptosis - Part 2
    • KN Bhalla 2003 Microtubule-targeted anticancer agents and apoptosis Oncogene 22 9075 9086 14663486 10.1038/sj.onc.1207233 1:CAS:528: DC%2BD3sXpsFOms78%3D (Pubitemid 38121708)
    • (2003) Oncogene , vol.22 , pp. 9075-9086
    • Bhalla, K.N.1
  • 13
    • 0034810579 scopus 로고    scopus 로고
    • Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: Attenuation by 17β-estradiol
    • DOI 10.1046/j.1471-4159.2001.00511.x
    • AJ Bruce-Keller SW Barger NI Moss, et al. 2001 Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol J Neurochem 78 1315 1324 11579140 10.1046/j.1471-4159.2001.00511.x 1:CAS:528:DC%2BD3MXnt12is7w%3D (Pubitemid 32899763)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.6 , pp. 1315-1324
    • Bruce-Keller, A.J.1    Barger, S.W.2    Moss, N.I.3    Pham, J.T.4    Keller, J.N.5    Nath, A.6
  • 14
    • 0141632883 scopus 로고    scopus 로고
    • Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain
    • AJ Bruce-Keller A Chauhan FO Dimayuga, et al. 2003 Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain J Neurosci 23 8417 8422 12968004 1:CAS:528:DC%2BD3sXnsVGnsro%3D (Pubitemid 37129659)
    • (2003) Journal of Neuroscience , vol.23 , Issue.23 , pp. 8417-8422
    • Bruce-Keller, A.J.1    Chauhan, A.2    Dimayuga, F.O.3    Gee, J.4    Keller, J.N.5    Nath, A.6
  • 15
    • 0037631328 scopus 로고    scopus 로고
    • Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport
    • DOI 10.1074/jbc.M209381200
    • A Chauhan J Turchan C Pocernich, et al. 2003 Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport J Biol Chem 278 13512 13519 12551932 10.1074/jbc.M209381200 1:CAS:528: DC%2BD3sXislGqs7Y%3D (Pubitemid 36800126)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 13512-13519
    • Chauhan, A.1    Turchan, J.2    Pocernich, C.3    Bruce-Keller, A.4    Roth, S.5    Butterfield, D.A.6    Major, E.O.7    Nath, A.8
  • 16
    • 12244304872 scopus 로고    scopus 로고
    • HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    • DOI 10.1093/emboj/cdf683
    • D Chen M Wang S Zhou, et al. 2002 HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the proapoptotic Bcl-2 relative Bim EMBO J 21 6801 6810 12486001 10.1093/emboj/cdf683 1:CAS:528:DC%2BD38XpslOgs74%3D (Pubitemid 36014552)
    • (2002) EMBO Journal , vol.21 , Issue.24 , pp. 6801-6810
    • Chen, D.1    Wang, M.2    Zhou, S.3    Zhou, Q.4
  • 18
    • 0031466304 scopus 로고    scopus 로고
    • Microtubule polymerization dynamics
    • DOI 10.1146/annurev.cellbio.13.1.83
    • A Desai TJ Mitchison 1997 Microtubule polymerization dynamics Annu Rev Cell Dev Biol 13 83 117 9442869 10.1146/annurev.cellbio.13.1.83 1:CAS:528:DyaK1cXisFSksg%3D%3D (Pubitemid 28034521)
    • (1997) Annual Review of Cell and Developmental Biology , vol.13 , pp. 83-117
    • Desai, A.1    Mitchison, T.J.2
  • 19
    • 48549083724 scopus 로고    scopus 로고
    • Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat
    • 18613978 10.1186/1742-4690-5-62
    • C Egele P Barbier P Didier, et al. 2008 Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat Retrovirology 5 62 18613978 10.1186/1742-4690-5-62
    • (2008) Retrovirology , vol.5 , pp. 62
    • Egele, C.1    Barbier, P.2    Didier, P.3
  • 21
    • 0038579653 scopus 로고    scopus 로고
    • MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis
    • DOI 10.1046/j.1471-4159.2003.01775.x
    • EA Eugenin TG D'Aversa L Lopez, et al. 2003 MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis J Neurochem 85 1299 1311 12753088 10.1046/j.1471-4159.2003.01775.x 1:CAS:528: DC%2BD3sXksVKqurc%3D (Pubitemid 36613277)
    • (2003) Journal of Neurochemistry , vol.85 , Issue.5 , pp. 1299-1311
    • Eugenin, E.A.1    D'Aversa, T.G.2    Lopez, L.3    Calderon, T.M.4    Berman, J.W.5
  • 22
    • 0030936357 scopus 로고    scopus 로고
    • Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes
    • DOI 10.1074/jbc.272.11.6951
    • LF Garcia-Martinez D Ivanov RB Gaynor 1997 Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes J Biol Chem 272 6951 6958 9054383 10.1074/jbc.272.11.6951 1:CAS:528:DyaK2sXhvFKjsL8%3D (Pubitemid 27166394)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.11 , pp. 6951-6958
    • Garcia-Martinez, L.F.1    Ivanov, D.2    Gaynor, R.B.3
  • 23
    • 18144371652 scopus 로고    scopus 로고
    • HIV-1 Tat, apoptosis and the mitochondria: A tubulin link?
    • DOI 10.1186/1742-4690-2-7
    • M Giacca 2005 HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? Retrovirology 2 7 15698476 10.1186/1742-4690-2-7 (Pubitemid 40617973)
    • (2005) Retrovirology , vol.2 , pp. 7
    • Giacca, M.1
  • 25
    • 11244271607 scopus 로고    scopus 로고
    • The neuropathogenesis of AIDS
    • DOI 10.1038/nri1527
    • F Gonzalez-Scarano J Martin-Garcia 2005 The neuropathogenesis of AIDS Nat Rev Immunol 5 69 81 15630430 10.1038/nri1527 1:CAS:528:DC%2BD2MXlvVOn (Pubitemid 40070332)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.1 , pp. 69-81
    • Gonzalez-Scarano, F.1    Martin-Garcia, J.2
  • 26
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • DOI 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U
    • A Jordan JA Hadfield NJ Lawrence, et al. 1998 Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle Med Res Rev 18 259 296 9664292 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0. CO;2-U 1:CAS:528:DyaK1cXkvVeisLY%3D (Pubitemid 28346389)
    • (1998) Medicinal Research Reviews , vol.18 , Issue.4 , pp. 259-296
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3    McGown, A.T.4
  • 27
    • 33744920797 scopus 로고    scopus 로고
    • HIV tat and neurotoxicity
    • DOI 10.1016/j.micinf.2005.11.014, PII S1286457906000049
    • JE King EA Eugenin CM Buckner, et al. 2006 HIV tat and neurotoxicity Microbes Infect 8 1347 1357 16697675 10.1016/j.micinf.2005.11.014 1:CAS:528:DC%2BD28XlsFOgsLY%3D (Pubitemid 43842005)
    • (2006) Microbes and Infection , vol.8 , Issue.5 , pp. 1347-1357
    • King, J.E.1    Eugenin, E.A.2    Buckner, C.M.3    Berman, J.W.4
  • 28
    • 0032412520 scopus 로고    scopus 로고
    • HIV-1 protein tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
    • DOI 10.1006/exnr.1998.6958
    • II Kruman A Nath MP Mattson 1998 HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress Exp Neurol 154 276 288 9878167 10.1006/exnr.1998.6958 1:CAS:528:DyaK1MXms1Kjsg%3D%3D (Pubitemid 29044201)
    • (1998) Experimental Neurology , vol.154 , Issue.2 , pp. 276-288
    • Kruman, I.I.1    Nath, A.2    Mattson, M.P.3
  • 29
    • 0034529953 scopus 로고    scopus 로고
    • Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
    • DOI 10.1038/82199
    • Y Liu M Jones CM Hingtgen, et al. 2000 Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands Nat Med 6 1380 1387 11100124 10.1038/82199 1:CAS:528:DC%2BD3cXosl2hs7o%3D (Pubitemid 32001023)
    • (2000) Nature Medicine , vol.6 , Issue.12 , pp. 1380-1387
    • Liu, Y.1    Jones, M.2    Hingtgen, C.M.3    Bu, G.4    Laribee, N.5    Tanzi, R.E.6    Moir, R.D.7    Nath, A.8    He, J.J.9
  • 30
    • 0031052029 scopus 로고    scopus 로고
    • Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells
    • M Ma A Nath 1997 Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells J Virol 71 2495 2499 9032389 1:CAS:528:DyaK2sXht1ajsbY%3D (Pubitemid 27078635)
    • (1997) Journal of Virology , vol.71 , Issue.3 , pp. 2495-2499
    • Ma, M.1    Nath, A.2
  • 31
    • 0037451775 scopus 로고    scopus 로고
    • Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat
    • DOI 10.1016/S0306-4522(02)00713-3
    • WF Maragos P Tillman M Jones, et al. 2003 Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat Neuroscience 117 43 53 12605891 10.1016/S0306-4522(02)00713-3 1:CAS:528:DC%2BD3sXhsVCiurg%3D (Pubitemid 36246502)
    • (2003) Neuroscience , vol.117 , Issue.1 , pp. 43-53
    • Maragos, W.F.1    Tillman, P.2    Jones, M.3    Bruce-Keller, A.J.4    Roth, S.5    Bell, J.E.6    Nath, A.7
  • 32
    • 0030797336 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau
    • MP Mattson W Fu G Waeq, et al. 1997 Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau Neuroreport 8 2275 2281 9243625 10.1097/00001756-199707070-00036 1:CAS:528:DyaK2sXlt1Wgtro%3D (Pubitemid 27319686)
    • (1997) NeuroReport , vol.8 , Issue.9-10 , pp. 2275-2281
    • Mattson, M.P.1    Fu, W.2    Waeg, G.3    Uchida, K.4
  • 33
    • 41849099281 scopus 로고    scopus 로고
    • Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: Significance of dicysteine C30C31 motif
    • DOI 10.1002/ana.21292
    • M Mishra S Vetrivel NB Siddappa, et al. 2008 Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: Significance of dicysteine C30C31 motif Ann Neurol 63 366 376 18074388 10.1002/ana.21292 1:CAS:528:DC%2BD1cXlt1CktLs%3D (Pubitemid 351499866)
    • (2008) Annals of Neurology , vol.63 , Issue.3 , pp. 366-376
    • Mishra, M.1    Vetrivel, S.2    Siddappa, N.B.3    Ranga, U.4    Seth, P.5
  • 34
    • 0034282238 scopus 로고    scopus 로고
    • Cytotoxicity of tributyltin in rat hippocampal slice cultures
    • 10997576 10.1016/S0168-0102(00)00137-1 1:CAS:528:DC%2BD3cXms1Wksb8%3D
    • S Mizuhashi Y Ikegaya N Matsuki 2000 Cytotoxicity of tributyltin in rat hippocampal slice cultures Neurosci Res 38 35 42 10997576 10.1016/S0168-0102(00) 00137-1 1:CAS:528:DC%2BD3cXms1Wksb8%3D
    • (2000) Neurosci Res , vol.38 , pp. 35-42
    • Mizuhashi, S.1    Ikegaya, Y.2    Matsuki, N.3
  • 37
    • 26944487265 scopus 로고    scopus 로고
    • Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures
    • DOI 10.1016/j.neuroscience.2005.07.043, PII S0306452205007980
    • PJ Mulholland TD Stepanyan RL Self, et al. 2005 Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures Neuroscience 136 259 267 16182452 10.1016/j.neuroscience.2005.07.043 1:CAS:528:DC%2BD2MXhtFersrbN (Pubitemid 41483853)
    • (2005) Neuroscience , vol.136 , Issue.1 , pp. 259-267
    • Mulholland, P.J.1    Stepanyan, T.D.2    Self, R.L.3    Hensley, A.K.4    Harris, B.R.5    Kowalski, A.6    Littleton, J.M.7    Prendergast, M.A.8
  • 38
    • 0030068995 scopus 로고    scopus 로고
    • Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic
    • A Nath K Psooy C Martin, et al. 1996 Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic J Virol 70 1475 1480 8627665 1:CAS:528:DyaK28XpvFagsw%3D%3D (Pubitemid 26062905)
    • (1996) Journal of Virology , vol.70 , Issue.3 , pp. 1475-1480
    • Nath, A.1    Psooy, K.2    Martin, C.3    Knudsen, B.4    Magnuson, D.S.K.5    Haughey, N.6    Geiger, J.D.7
  • 39
    • 0033006380 scopus 로고    scopus 로고
    • The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin
    • DOI 10.1046/j.1471-4159.1999.0722323.x
    • MD Neely KR Sidell DG Graham, et al. 1999 The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules and modifies cellular tubulin J Neurochem 72 2323 2333 10349841 10.1046/j.1471-4159. 1999.0722323.x 1:CAS:528:DyaK1MXjsV2hs7s%3D (Pubitemid 29242182)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.6 , pp. 2323-2333
    • Neely, M.D.1    Sidell, K.R.2    Graham, D.G.3    Montine, T.J.4
  • 40
    • 0032953691 scopus 로고    scopus 로고
    • Markers for neuronal degeneration in organotypic slice cultures
    • DOI 10.1016/S1385-299X(98)00050-6, PII S1385299X98000506
    • J Noraberg BW Kristensen J Zimmer 1999 Markers for neuronal degeneration in organotypic slice cultures Brain Res Protoc 3 278 290 10.1016/S1385-299X(98) 00050-6 1:CAS:528:DyaK1MXosF2ksg%3D%3D (Pubitemid 29023528)
    • (1999) Brain Research Protocols , vol.3 , Issue.3 , pp. 278-290
    • Noraberg, J.1    Kristensen, B.W.2    Zimmer, J.3
  • 41
    • 0037044856 scopus 로고    scopus 로고
    • Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor
    • DOI 10.1016/S0006-8993(02)03360-7, PII S0006899302033607
    • MA Prendergast DT Rogers PJ Mulholland, et al. 2002 Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor Brain Res 954 300 307 12414113 10.1016/S0006-8993(02)03360-7 1:CAS:528:DC%2BD38Xot1Wqsbc%3D (Pubitemid 35284670)
    • (2002) Brain Research , vol.954 , Issue.2 , pp. 300-307
    • Prendergast, M.A.1    Rogers D.Trent2    Mulholland, P.J.3    Littleton, J.M.4    Wilkins Jr., L.H.5    Self, R.L.6    Nath, A.7
  • 43
    • 19444362384 scopus 로고    scopus 로고
    • HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells
    • DOI 10.1016/j.brainres.2005.03.031, PII S0006899305004609
    • TO Price N Ercal R Nakaoke, et al. 2005 HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells Brain Res 1045 57 63 15910762 1:CAS:528:DC%2BD2MXks1antr0%3D (Pubitemid 40725220)
    • (2005) Brain Research , vol.1045 , Issue.1-2 , pp. 57-63
    • Price, T.O.1    Ercal, N.2    Nakaoke, R.3    Banks, W.A.4
  • 44
    • 0842265000 scopus 로고    scopus 로고
    • Dendritic changes in the hippocampal formation of AIDS patients: A quantitative Golgi study
    • DOI 10.1007/s00401-003-0781-3
    • MJ Sa MD Madeira C Ruela, et al. 2004 Dendritic changes in the hippocampal formation of AIDS patients: a quantitative Golgi study Acta Neuropathol 107 97 110 14605830 10.1007/s00401-003-0781-3 1:STN:280: DC%2BD2c%2FjvVOmtQ%3D%3D (Pubitemid 38165259)
    • (2004) Acta Neuropathologica , vol.107 , Issue.2 , pp. 97-110
    • Sa, M.J.1    Madeira, M.D.2    Ruela, C.3    Volk, B.4    Mota-Miranda, A.5    Paula-Barbosa, M.M.6
  • 45
    • 10844258260 scopus 로고    scopus 로고
    • Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment
    • DOI 10.1097/01.ALC.0000148108.93782.05
    • RL Self PJ Mulholland BR Harris, et al. 2004 Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment Alcohol Clin Exp Res 28 1916 1924 15608609 10.1097/01.ALC.0000148108.93782.05 1:CAS:528:DC%2BD2cXhtVyltL7J (Pubitemid 39665209)
    • (2004) Alcoholism: Clinical and Experimental Research , vol.28 , Issue.12 , pp. 1916-1924
    • Self, R.L.1    Mulholland, P.J.2    Harris, B.R.3    Nath, A.4    Prendergast, M.A.5
  • 46
    • 0345303772 scopus 로고    scopus 로고
    • 2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site
    • DOI 10.1016/j.brainres.2003.09.052
    • RL Self PJ Mulholland A Nath, et al. 2004 The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2 + that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site Brain Res 995 39 45 14644469 10.1016/j.brainres.2003.09.052 1:CAS:528:DC%2BD3sXptlOrtLg%3D (Pubitemid 37486013)
    • (2004) Brain Research , vol.995 , Issue.1 , pp. 39-45
    • Self, R.L.1    Mulholland, P.J.2    Nath, A.3    Harris, B.R.4    Prendergast, M.A.5
  • 47
    • 70449650501 scopus 로고    scopus 로고
    • Neurologic presentations of AIDS
    • 19932385 10.1016/j.ncl.2009.09.018
    • EJ Singer M Valdes-Sueiras D Commins, et al. 2010 Neurologic presentations of AIDS Neurol Clin 28 253 275 19932385 10.1016/j.ncl.2009.09.018
    • (2010) Neurol Clin , vol.28 , pp. 253-275
    • Singer, E.J.1    Valdes-Sueiras, M.2    Commins, D.3
  • 48
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures in nervous tissue
    • 1715499 10.1016/0165-0270(91)90128-M 1:STN:280:DyaK3MzltVymtA%3D%3D
    • L Stoppini PA Buchs D Muller 1991 A simple method for organotypic cultures in nervous tissue J Neurosci Methods 37 173 182 1715499 10.1016/0165-0270(91)90128-M 1:STN:280:DyaK3MzltVymtA%3D%3D
    • (1991) J Neurosci Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 51
    • 0032880829 scopus 로고    scopus 로고
    • The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
    • DOI 10.1007/s002800050989
    • LG Wang XM Liu W Kreis, et al. 1999 The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review Cancer Chemother Pharmacol 44 355 361 10501907 10.1007/s002800050989 1:CAS:528:DyaK1MXmsVWlu7w%3D (Pubitemid 29455579)
    • (1999) Cancer Chemotherapy and Pharmacology , vol.44 , Issue.5 , pp. 355-361
    • Wang, L.G.1    Liu, X.M.2    Kreis, W.3    Budman, D.R.4
  • 52
    • 0028861429 scopus 로고
    • HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state
    • 7859743 1:CAS:528:DyaK2MXjs1Kgtrg%3D
    • MO Westendorp VA Shatrov K Schulze-Osthoff, et al. 1995 HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state EMBO J 14 546 554 7859743 1:CAS:528:DyaK2MXjs1Kgtrg%3D
    • (1995) EMBO J , vol.14 , pp. 546-554
    • Westendorp, M.O.1    Shatrov, V.A.2    Schulze-Osthoff, K.3
  • 53
    • 33749000311 scopus 로고    scopus 로고
    • Local caspase activity directs engulfment of dendrites during pruning
    • DOI 10.1038/nn1774, PII NN1774
    • DW Williams S Kondo A Krzyzanowska, et al. 2006 Local caspase acitivity directs engulfment of dendrites during pruning Nat Neurosci 9 1234 1236 16980964 10.1038/nn1774 1:CAS:528:DC%2BD28XhtVSgu7fP (Pubitemid 44454262)
    • (2006) Nature Neuroscience , vol.9 , Issue.10 , pp. 1234-1236
    • Williams, D.W.1    Kondo, S.2    Krzyzanowska, A.3    Hiromi, Y.4    Truman, J.W.5
  • 54
    • 67649085899 scopus 로고    scopus 로고
    • The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: A foreseeable medical challenge in post-HAART era
    • 10.1007/s11481-008-9136-0 1:CAS:528:DC%2BD1MXpsV2js7k%3D
    • J Xu T Ikez 2009 The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era Neuroimmune Pharmacol 4 200 212 10.1007/s11481-008-9136-0 1:CAS:528:DC%2BD1MXpsV2js7k%3D
    • (2009) Neuroimmune Pharmacol , vol.4 , pp. 200-212
    • Xu, J.1    Ikez, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.