Multidrug resistance reversal by 3-formylchromones in human colon concer and human mdr1 gene-transfected mouse lymphoma cells

In Vivo

Volumn 20, Issue 5, 2006, Pages 645-650

  Baráth, Zoltán ^a   Radics, Rita ^a   Spengler, Gabriella ^a   Ocsovszki, Imre ^b   Kawase, Masami ^c   Motohashi, Noboru ^d   Shirataki, Yoshiaki ^c   Shah, Anamik ^e   Molnár, József ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c JOSAI UNIVERSITY   (Japan)

^d MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^e SAURASHTRA UNIVERSITY   (India)

Author keywords

Formylchromones; Multidrug resistance reversing effect

Indexed keywords

3 ACETYLCOUMARIN; 3 FORMYL 6 ISOPROPYLCHROMONE; 3 FORMYL 6 METHYLCHROMONE; 3 FORMYL 6 NITROCHROMONE; 3 FORMYLCHROMONE; 6 BROMO 3 FORMYLCHROMONE; 6 CHLORO 3 FORMYL 7 METHYLCHROMONE; 6 CHLORO 3 FORMYLCHROMONE; 6 CYANOCHROMONE; 6 FLUORO 3 FORMYLCHROMONE; 6 METHOXY 3 FORMYLCHROMONE; 6,8 DIBROMO 3 FORMYLCHROMONE; 6,8 DICHLORO 3 FORMYLCHROMONE; ANTINEOPLASTIC AGENT; CHROMONE; CHROMONE DERIVATIVE; COUMARIN 3 CARBOXYLIC ACID; COUMARIN DERIVATIVE; ETHYLCOUMARIN 3 CARBOXYLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DIPOLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOMA CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY;

EID: 33750593936     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Gottesman MM and Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Rev Biochem 62: 385-427, 1993.
2. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC: Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and cross reactivity of one antibody with a muscle protein. J Histochem Cytochem 37: 159-164, 1989.
3. Molnár J, Szabo D, Mándi Y, Mucsi I, Fischer J, Varga A, König S and Motohashi N: Multidrug resistance reversal in mouse lymphoma cells by heterocyclic compounds. Anticancer Res 18: 3033-3038, 1998.
4. Ruetz S and Gross P: Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77: 1071-1081, 1994.
5. Zhou Y, Gottesman MM and Pastan I: Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2). Mol Pharmacol 56(5): 997-1004, 1999.
6. Molnár J, Gyémánt N, Mucsi I, Molnár A, Szabó M, Körtvétyesi T, Varga A, Molnár P and Toth Gy: Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo 18: 237-244, 2004.
7. Dimmock JR, Das U, Gul HI, Kawase M, Sakagami H, Baráth Z, Ocsovszki I and Molnár J: 3-Arylidene-l-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalene-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells. Bioorganic and Medicinal Chemistry Letters 15: 1633-1636, 2005.
8. Cornwell MM, Pastan I and Gottesmann M: Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987.
9. Gruber A, Peterson C and Reizenstein P: D-verapamil and L-verapamil are equally effective in increasing vincri stine accumulation in leukemic cells in vitro. Int J Cancer 41: 224-226, 1988.
10. Ryabukhin SV, Plaskon AS, Volochnyuk DM and Tolmachev AA: 3-Formylchromones in Guareschi synthesis of 5-(2-hydroxybenzoyl)-2-pyridones. Synlett 13: 2287-2290, 2004.
11. Gyémánt N, Tanaka M, Antus S, Hohmann J, Csuka O, Mándoky L and Molnár J: In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In Vivo 19: 367-374, 2005.
12. Ugocsai K, Varga A, Molnár P, Antus S and Molnár J: Effets of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDRl/LRP. In Vivo 19: 433-438, 2005.
13. Molnar P, Kawase M, Satoh Y, Sohara Y, Tanaka T, Tani S, Sakagami H, Nakashima H, Motohashi N, Gyemant N and Molnar J: Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple. Phytother Res 19(8): 700-707, 2005.
14. Ferreira MJ, Gyemant N, Madureira AM and Molnar J: Inhibition of P-glycoprotein transport activity in a resistant mouse lymphoma cell line by diterpenic lactones. Anticancer Res 25(5): 3259-3262, 2005.
15. Ferreira MJU, Gyemant N, Madureira AM, Tanaka M, Koós K, Didiziapetris R and Molnár J: The effects of jatrophane derivatives on the reversion of MDR-1 and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line. Anticancer Res 25: 4173-4178, 2005.
16. Molnás J, Gyémánt N, Tanaka M, Hohmann J, Bergmann-Leitner E, Molnár P, Deli J, Didiziapetris, R and Ferreira MJU: Inhibition of multidrug resistance of cancer cells by natural diterpenes, triterpenes and carotenoids. Current Pharm Design 12(3): 287-311, 2006.
17. Valente C, Ferreira MJ, Abreu PM, Gyemant N, Ugocsai V, Hohmann J and Molnar J: Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells. Planta Med 70: 81-84, 2004.
18. Shirataki Y, Kawase M, Sakagami H, Nakashima H, Tani S, Tanaka T, Sohara Y, Schelz Z, Molnar J and Motohashi N: Bioactivities of anastasia black (Russian sweet pepper). Anticancer Res 25(3B): 1991-2000, 2005.
19. Molnár J, Mucsi I, Nacsa J, Hevér A, Gyémánt N, Ugocsai K, Hegyes P, Kiessig ST, Gaal D, Lage H and Varga A: New silicon compounds as resistance, modifiers against multidrug-resistant cancer cells. Anticancer Res 24: 865-872, 2004.
20. Pajak B, Molnár J, Engi H and Orzechowski A: Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells. In Vivo 19(6): 1101-1104, 2005.
21. Sharples D, Spengler G, Molnár J, Antal Zs, Molnár A, Kiss TJ, Szabó AJ, Hilgeroth A, Gallo S, Mahamoud A and Barbe J: The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA Eur J Med Chem 40: 195-202, 2005.
22. Szabó D and Molnár J: The role of stereoselectivity of chemosensitizers in the reversal of multidrug resistance of mouse lymphoma cells. Anticancer Res 18: 3039-3044, 1998.
23. Kawase M, Sakagami H, Motohashi N, Hauer H, Chatterje SS, Spengler G, Vigyikanne AV, Molnar A and Molnar J: Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity. In Vivo 19(4): 705-712, 2005.
24. Gyémánt N: Multidrug restistance reversal effect of organosilicon, terpenoid and flavonoid derivatives on various tumor cell lines in vitro. Ph. D. Thesis. Hungarian Academy of Science, p. 33, 2005.