Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28

Toxicon

Volumn 59, Issue 2, 2012, Pages 241-248

  Carey, Clayton M ^a   Bueno, Raymund ^a   Gutierrez, Daniel A ^a   Petro, Christopher ^a   Lucena, Sara E ^b   Sanchez, Elda E ^b,c   Soto, Julio G ^a  

^a SAN JOSE STATE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

Author keywords

Apoptosis induction; Cell migration; Cell proliferation; Melanoma cell line; MVD disintegrin; Recombinant disintegrin

Indexed keywords

APOPTOSIS INDUCING FACTOR; DISINTEGRIN; RECOMBINANT RUBISTATIN; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; ESCHERICHIA COLI; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; MELANOMA CELL; MIGRATION INHIBITION; NICK END LABELING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CLONING, MOLECULAR; CROTALID VENOMS; CROTALUS; DISINTEGRINS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PLATELET AGGREGATION; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA;

CROTALUS RUBER RUBER; ESCHERICHIA COLI; VIPERINAE;

EID: 84855225404     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.12.002     Document Type: Article

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