VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom. Purification and cDNA cloning

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 153, Issue 3, 2009, Pages 253-260

  Vija, Heiki ^a   Samel, Mari ^a   Siigur, Ene ^a   Aaspõllu, Anu ^a   Tõnismägi, Külli ^a   Trummal, Katrin ^a   Subbi, Juhan ^a   Siigur, Jüri ^a  

^a NATIONAL INSTITUTE OF CHEMICAL PHYSICS AND BIOPHYSICS   (Estonia)

Author keywords

cDNA cloning; Heterodimeric disintegrin; Metalloprotease disintegrin; Platelet aggregation; Snake venom; Tandem polyadenylation; Vipera lebetina

Indexed keywords

COMPLEMENTARY DNA; DISINTEGRIN; DISINTEGRIN VIPLEBEDIN 2; HETERODIMER; METALLOPROTEINASE; METALLOPROTEINASE LEBETASE; SEPHADEX; SIGNAL PEPTIDE; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DNA PURIFICATION; GEL PERMEATION CHROMATOGRAPHY; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN SYNTHESIS; SNAKE; THROMBOCYTE AGGREGATION; VIPERA LEBETINA;

MACROVIPERA LEBETINA;

EID: 67349253023     PISSN: 10964959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpb.2009.03.002     Document Type: Article

References (51)

1. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., and Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25 (1997) 3389-3402
2. Ara T., Lopez F., Ritchie W., Benech P., and Gautheret D. Conservation of alternative polyadenylation patterns in mammalian genes. BMC Genomics 7 (2006) 189
3. 1 integrins. Biochemistry 43 (2004) 1639-1647
4. Beaudoing E., Freier S., Wyatt J.R., Claverie J.M., and Gautheret D. Patterns of variant polyadenylation signal usage in human genes. Genome Res. 10 (2000) 1001-1010
5. Bellavite P., Andrioli G., Guzzo P., Arigliano P., Chirumbolo S., Manzato F., and Santonastaso C.A. A colorimetric method for the measurement of platelet adhesion in microtiter plates. Anal. Biochem. 216 (1994) 444-450
6. Calvete J.J. Structure-function correlations of snake venom disintegrins. Curr. Pharm. Des. 11 (2005) 829-835
7. Calvete J.J., Moreno-Murciano M.P., Theakston R.D.G., Kisiel D.G., and Marcinkiewicz C. Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem. J. 372 (2003) 725-734
8. Calvete J.J., Marcinkiewicz C., Monleón D., Esteve V., Celda B., Juárez P., and Sanz L. Snake venom disintegrins: evolution of structure and function. Toxicon 45 (2005) 1063-1074
9. Eble J.A., and Haier J. Integrins in cancer treatment. Curr. Cancer Drug Targets 6 (2006) 561-571
10. 1 integrins. J. Biol. Chem 278 (2003) 26488-26496
11. Edwalds-Gilbert G., Veraldi K.L., and Milcarek C. Alternative poly(A) site selection in complex transcription units: means to an end?. Nucleic Acids Res. 25 (1997) 2547-2561
12. Farndale R.W., Sixma J.J., Barnes M.J., and de Groot P.G. The role of collagen in thrombosis and hemostasis. J. Thromb. Haemost 2 (2004) 561-573
13. Francischetti I.M., My-Pham V., Harrison J., Garfield M.K., and Ribeiro J.M. Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins. Gene 337 (2004) 55-69
14. Fry B.G. Structure-function properties of venom components from Australian elapids. Toxicon 37 (1999) 11-32
15. Fry B.G., and Wuster W. Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences. Mol. Biol. Evol 21 (2004) 870-873
16. Gasmi A., Srairi N., Guermazi S., Dkhil H., Karoui H., and El Ayeb M. Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom. Biochim. Biophys. Acta 1547 (2001) 51-56
17. Gautheret D., Poirot O., Lopez F., Audic S., and Claverie J.M. Alternate polyadenylation in human mRNAs: a large-scale analysis by EST clustering. Genome Res. 8 (1998) 524-530
18. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
19. Hite L.A., Shannon J.D., Bjarnason J.B., and Fox J.W. Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin e from Crotalus atrox: evidence for signal, zymogen, and disintegrin-like structures. Biochemistry 31 (1992) 6203-6211
20. Hong S.Y., Koh Y.S., Chung C.H., and Kim D.S. Snake venom disintegrin, saxatilin, inhibits platelet aggregation, human umbilical vein endothelial cell proliferation, and smooth muscle cell migration. Thromb. Res. 105 (2002) 79-86
21. Juarez P., Wagstaff S.C., Sanz L., Harrison R.A., and Calvete J.J. Molecular cloning of Echis ocellatus disintegrins reveals non-venom-secreted proteins and a pathway for the evolution of ocellatusin. J. Mol. Evol 63 (2006) 183-193
22. Kallech-Ziri O., Lois J., Daoud S., Bazaa A., Srairi A.N., Andreotti N., Lehmann M., Zouari R., Mabrouk K., Marvaldi J., Sabatier J.M., El-Ayeb M., and Marrakchi N. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab. Invest 85 (2005) 1507-1516
23. Knight L.C., and Romano J.E. Functional expression of bitistatin, a disintegrin with potential use in molecular imaging of thromboembolic disease. Protein Expr. Purif 39 (2005) 307-319
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
25. Marcinkiewicz C. Functional characteristic of snake venom disintegrins: potential therapeutic implication. Curr. Pharm. Des. 11 (2005) 815-827
26. Marcinkiewicz C., Calvete J.J., Marcinkiewicz M.M., Raida M., Vijay-Kumar S., Huang Z., Lobb R.R., and Niewiarowski S. EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits α4 and α5 integrins in an RGD-independent manner. J. Biol. Chem 274 (1999) 12468-12473
27. Markland F.S. Snake venoms. Drugs Suppl 54 (1997) 31-40
28. Markland F.S. Snake venoms and the hemostatic system. Toxicon 36 (1998) 1749-1800
29. Markland F.S., Shieh K., Zhou Q., Golubkov V., Sherwin R.P., Richters V., and Sposto R. A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model. Haemostasis 31 (2001) 183-191
30. McLane M.A., and Paquette-Straub C. On behalf of the Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis*. Scientific and standardization committee communications: classification and nomenclature of disintegrins isolated from snake venoms. J. Thromb. Haemost 5 (2007) 1971
31. McLane M.A., Sanchez E.E., Wong A., Paquette-Straub C., and Perez J.C. Disintegrins. Curr. Drug Targets Cardiovasc. Haematol. Disord. 4 (2004) 327-355
32. McLane M.A., Zhang X., Tian J., and Paquette-Straub C. Monomeric and dimeric disintegrins: platelet active agents from viper venom. Toxin Revs. 25 (2006) 435-464
33. McLane M.A., Joerger T., and Mahmoud A. Disintegrins in health and disease. Front. Biosci 13 (2008) 6617-6637
34. Okuda D., Koike H., and Morita T. A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region. Biochemistry 41 (2002) 14248-14254
35. Plow E.F., Haas T.A., Zhang L., Loftus J., and Smith J.W. Ligand binding to integrins. J. Biol. Chem 275 (2000) 21785-21788
36. Sanchez E.E., Galan J.A., Russell W.K., Soto J.G., Russell D.H., and Perez J.C. Isolation and characterization of two disintegrins inhibiting ADP-induced human platelet aggregation from the venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake). Toxicol. Appl. Pharmacol. 212 (2006) 59-68
37. Sanz L., Bazaa A., Marrakchi N., Perez A., Chenik M., Bel Lasfer Z., El Ayeb M., and Calvete J.J. Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system. Biochem. J. 395 (2006) 385-392
38. Shimaoka M., and Springer T.A. Therapeutic antagonists and conformational regulation of integrin function. Nat. Rev. Drug Discov. 2 (2003) 703-716
39. Siigur E., Aaspollu A., Tu A.T., and Siigur J. cDNA cloning and deduced amino acid sequence of fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochem. Biophys. Res. Commun 224 (1996) 229-236
40. Siigur J., Samel M., Tonismagi K., Subbi J., Siigur E., and Tu A.T. Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thromb. Res 90 (1998) 39-49
41. Siigur E., Aaspollu A., Trummal K., Tonismagi K., Tammiste I., Kalkkinen N., and Siigur J. Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochim. Biophys. Acta 1702 (2004) 41-51
42. Siigur E., Samel M., Tonismagi K., Vija H., Trummal K., Aaspollu A., Pikver R., Subbi J., and Siigur J. Platelet aggregation inhibiting components from Vipera lebetina snake venom. J. Thromb. Haemost. 5 Supplement 2 (2007) P-S-272
43. Swenson S., Costa F., Ernst W., Fujii G., and Markland F.S. Contortrostatin, a snake venom disintegrin with anti-angiogenic and anti-tumor activity. Pathophysiol. Haemost. Thromb 34 (2005) 169-176
44. Takeya H., Nishida S., Nishino N., Makinose Y., Omori-Satoh T., Nikai T., Sugihara H., and Iwanaga T. Primary structures of platelet aggregation inhibitors (disintegrins) autoproteolytically released from snake venom hemorrhagic metalloproteinases and new fluorogenic peptide substrates for these enzymes. J. Biochem 113 (1993) 473-483
45. Tian B., Hu J., Zhang H., and Lutz C.S. A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res 33 (2005) 201-212
46. Trummal K., Vija H., Subbi J., and Siigur J. MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochim. Biophys. Acta 1476 (2000) 331-336
47. Trummal K., Tõnismägi K., Siigur E., Aaspõllu A., Lopp A., Sillat T., Saat R., Kasak L., Tammiste I., Kogerman P., Kalkkinen N., and Siigur J. A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon 46 (2005) 46-61
48. Tõnismägi K., Samel M., Trummal K., Ronnholm G., Siigur J., Kalkkinen N., and Siigur E. L-amino acid oxidase from Vipera lebetina venom: isolation, characterization, effects on platelets and bacteria. Toxicon 48 (2006) 227-237
49. Zhou Q., Hu P., Ritter M.R., Swenson S.D., Argounova S., Epstein A.L., and Markland F.S. Molecular cloning and functional expression of contortrostatin, a homodimeric disintegrin from southern copperhead snake venom. Arch. Biochem. Biophys 375 (2000) 278-288
50. Zhou Q., Sherwin R.P., Parrish C., Richters V., Groshen S.G., Tsao-Wei D., and Markland F.S. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression. Breast Cancer Res. Treat. 61 (2000) 249-260
51. Zhu S., and Tytgat J. The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition. Cell. Mol. Life Sci. 61 (2004) 1751-1763