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Volumn 1433, Issue , 2012, Pages 104-113

Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease

Author keywords

1 methyl 4 phenyl 1, 2, 3, 6 tetrahydropyridine probenecid (MPTP p); Apoptosis; Dopamine transporter; Theaflavin; Tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BLACK TEA EXTRACT; CASPASE 3; CASPASE 8; CASPASE 9; DOPAMINE TRANSPORTER; POLYPHENOL; PROBENECID; THEAFLAVIN; TYROSINE 3 MONOOXYGENASE;

EID: 84855204111     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.11.021     Document Type: Article
Times cited : (96)

References (56)
  • 1
    • 34248164348 scopus 로고    scopus 로고
    • Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: Relevance to oxidative damage in Parkinson's disease
    • DOI 10.1016/j.neuint.2007.02.003, PII S0197018607000460
    • V. Anantharam, E. Lehrmann, K. Kanthasamy, Y. Yang, P. Banerjee, K.G. Becker, W.J. Freed, and A.G. Kanthasamy Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease Neurochem. Int. 50 2007 834 847 (Pubitemid 46722646)
    • (2007) Neurochemistry International , vol.50 , Issue.6 , pp. 834-847
    • Anantharam, V.1    Lehrmann, E.2    Kanthasamy, A.3    Yang, Y.4    Banerjee, P.5    Becker, K.G.6    Freed, W.J.7    Kanthasamy, A.G.8
  • 3
    • 73049129373 scopus 로고
    • The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia
    • W. Birkmayer, and O. Hornykiewicz The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia Wien. Klin. Wochenschr. 73 1961 787 788
    • (1961) Wien. Klin. Wochenschr. , vol.73 , pp. 787-788
    • Birkmayer, W.1    Hornykiewicz, O.2
  • 4
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • DOI 10.1016/S0301-0082(01)00003-X, PII S030100820100003X
    • D. Blum, S. Torch, N. Lambeng, M. Nissou, A.L. Benabid, R. Sadoul, and J.M. Verna Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease Prog. Neurobiol. 65 2001 135 172 (Pubitemid 32524182)
    • (2001) Progress in Neurobiology , vol.65 , Issue.2 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.-F.4    Benabid, A.-L.5    Sadoul, R.6    Verna, J.-M.7
  • 5
    • 34247185925 scopus 로고    scopus 로고
    • Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1
    • F. Cai, C.R. Li, J.L. Wu, J.G. Chen, C. Liu, Q. Min, W. Yu, C.H. Ouyang, and J.H. Chen Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1 Mediators Inflamm. 2006 2006 1 9
    • (2006) Mediators Inflamm. , vol.2006 , pp. 1-9
    • Cai, F.1    Li, C.R.2    Wu, J.L.3    Chen, J.G.4    Liu, C.5    Min, Q.6    Yu, W.7    Ouyang, C.H.8    Chen, J.H.9
  • 6
    • 79954437554 scopus 로고    scopus 로고
    • Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds
    • M. Caruana, T. Högen, J. Levin, A. Hillmer, A. Giese, and N. Vassallo Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds FEBS Lett. 585 2011 1113 1120
    • (2011) FEBS Lett. , vol.585 , pp. 1113-1120
    • Caruana, M.1    Högen, T.2    Levin, J.3    Hillmer, A.4    Giese, A.5    Vassallo, N.6
  • 7
    • 33646137778 scopus 로고    scopus 로고
    • Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    • R.K. Chaturvedi, S. Shukla, K. Seth, S. Chauhan, C. Sinha, Y. Shukla, and A.K. Agrawal Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease Neurobiol. Dis. 22 2006 421 434
    • (2006) Neurobiol. Dis. , vol.22 , pp. 421-434
    • Chaturvedi, R.K.1    Shukla, S.2    Seth, K.3    Chauhan, S.4    Sinha, C.5    Shukla, Y.6    Agrawal, A.K.7
  • 9
    • 44449128168 scopus 로고    scopus 로고
    • Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: Role of MAPK- and JAK/STAT-signaling
    • J.S. Choi, Y.J. Choi, S.Y. Shin, J. Li, S.W. Kang, J.Y. Bae, D.S. Kim, G.E. Ji, J.S. Kang, and Y.H. Kang Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: role of MAPK- and JAK/STAT-signaling J. Nutr. 138 2008 983 990 (Pubitemid 351769118)
    • (2008) Journal of Nutrition , vol.138 , Issue.6 , pp. 983-990
    • Choi, J.-S.1    Choi, Y.-J.2    Shin, S.-Y.3    Li, J.4    Kang, S.-W.5    Bae, J.-Y.6    Dong, S.K.7    Ji, G.-E.8    Kang, J.-S.9    Kang, Y.-H.10
  • 10
    • 58149333148 scopus 로고    scopus 로고
    • Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model
    • Y.G. Choi, J.H. Park, and S. Lim Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model Neurosci. Lett. 450 2009 92 96
    • (2009) Neurosci. Lett. , vol.450 , pp. 92-96
    • Choi, Y.G.1    Park, J.H.2    Lim, S.3
  • 13
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909 (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 14
    • 0030984429 scopus 로고    scopus 로고
    • Involvement of a caspase-3-like cysteine protease in 1-methyl-4- phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons
    • Y. Du, R.C. Dodel, K.R. Bales, R. Jemmerson, E. Hamilton-Byrd, and S.M. Paul Involvement of a caspase-3-like cysteine protease in 1-methyl-4- phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons J. Neurochem. 69 1997 1382 1388 (Pubitemid 27406938)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.4 , pp. 1382-1388
    • Du, Y.1    Dodel, R.C.2    Bales, K.R.3    Jemmerson, R.4    Hamilton-Byrd, E.5    Paul, S.M.6
  • 15
    • 0034941792 scopus 로고    scopus 로고
    • A review of latest research findings on the health promotion properties of tea
    • DOI 10.1016/S0955-2863(01)00155-3, PII S0955286301001553
    • C.J. Dufresne, and E.R. Farnworth A review of latest research findings on the health promotion properties of tea J. Nutr. Biochem. 7 2001 404 421 (Pubitemid 32633828)
    • (2001) Journal of Nutritional Biochemistry , vol.12 , Issue.7 , pp. 404-421
    • Dufresne, C.J.1    Farnworth, E.R.2
  • 16
    • 0037196246 scopus 로고    scopus 로고
    • A simple method to measure stride length as an index of nigrostriatal dysfunction in mice
    • DOI 10.1016/S0165-0270(01)00485-X, PII S016502700100485X
    • P.O. Fernagut, E. Diguet, B. Labattu, and F. Tison A simple method to measure stride length as an index of nigrostriatal dysfunction in mice J. Neurosci. Methods 113 2002 123 130 (Pubitemid 34076535)
    • (2002) Journal of Neuroscience Methods , vol.113 , Issue.2 , pp. 123-130
    • Fernagut, P.O.1    Diguet, E.2    Labattu, B.3    Tison, F.4
  • 18
    • 0141639855 scopus 로고    scopus 로고
    • Antioxidant activity of tea polyphenols in vivo: Evidence from animal studies
    • B. Frei, and J.V. Higdon Antioxidant activity of tea polyphenols in vivo: evidence from animal studies J. Nutr. 133 2003 3275 3284
    • (2003) J. Nutr. , vol.133 , pp. 3275-3284
    • Frei, B.1    Higdon, J.V.2
  • 19
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • DOI 10.1056/NEJMra022366
    • R.M. Friedlander Apoptosis and caspases in neurodegenerative diseases N. Engl. J. Med. 348 2003 1365 1375 (Pubitemid 36384105)
    • (2003) New England Journal of Medicine , vol.348 , Issue.14 , pp. 1365-1375
    • Friedlander, R.M.1
  • 20
    • 0032767876 scopus 로고    scopus 로고
    • Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study
    • DOI 10.1093/brain/122.7.1271
    • T. Hanakawa, Y. Katsumi, H. Fukuyuma, M. Honda, T. Hayashi, J. Kimura, and H. Shibasaki Mechanisms underlying gait disturbance in Parkinson's disease: a single photon emission computed tomography study Brain 122 1999 1271 1282 (Pubitemid 29324848)
    • (1999) Brain , vol.122 , Issue.7 , pp. 1271-1282
    • Hanakawa, T.1    Katsumi, Y.2    Fukuyama, H.3    Honda, M.4    Hayashi, T.5    Kimura, J.6    Shibasaki, H.7
  • 22
    • 0035313071 scopus 로고    scopus 로고
    • Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
    • A. Hartmann, J.D. Troadec, S. Hunot, K. Kikly, B.A. Faucheux, A. Mouatt- Prigent, M. Ruberg, Y. Agid, and E.C. Hirsch Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis J. Neurosci. 21 2001 2247 2255 (Pubitemid 32240523)
    • (2001) Journal of Neuroscience , vol.21 , Issue.7 , pp. 2247-2255
    • Hartmann, A.1    Troadec, J.-D.2    Hunot, S.3    Kikly, K.4    Faucheux, B.A.5    Mouatt-Prigent, A.6    Ruberg, M.7    Agid, Y.8    Hirsch, E.C.9
  • 23
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
    • R.E. Heikkila, L. Manzino, F.S. Cabbat, and R.C. Duvoisin Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine by monoamine oxidase inhibitors Nature 311 1984 467 469 (Pubitemid 14035453)
    • (1984) Nature , vol.311 , Issue.5985 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Duvoisin, R.C.4
  • 24
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • DOI 10.1016/S0891-5849(00)00498-6, PII S0891584900004986
    • K. Ishige, D. Schubert, and Y. Sagara Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms Free Radic. Biol. Med. 30 2001 433 446 (Pubitemid 32155542)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.4 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 25
    • 0028784523 scopus 로고
    • Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine
    • V. Jackson-Lewis, M. Jakowec, R.E. Burke, and S. Przedborski Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine Neurodegeneration 4 1995 257 269
    • (1995) Neurodegeneration , vol.4 , pp. 257-269
    • Jackson-Lewis, V.1    Jakowec, M.2    Burke, R.E.3    Przedborski, S.4
  • 26
    • 34347251501 scopus 로고    scopus 로고
    • Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra
    • DOI 10.1016/j.neuint.2007.03.006, PII S0197018607000733
    • H. Jiang, N. Song, J. Wang, L. Ren, and J. Xie Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra Neurochem. Int. 51 2007 32 36 (Pubitemid 47002045)
    • (2007) Neurochemistry International , vol.51 , Issue.1 , pp. 32-36
    • Jiang, H.1    Song, N.2    Wang, J.3    Ren, L.-Y.4    Xie, J.-X.5
  • 27
    • 0032901351 scopus 로고    scopus 로고
    • Antimutagenic and anticarcinogenic activity of tea polyphenols
    • DOI 10.1016/S1383-5742(98)00019-2, PII S1383574298000192
    • Y. Kuroda, and Y. Hara Antimutagenic and anticarcinogenic activity of tea polyphenols Mutat. Res. 436 1999 69 97 (Pubitemid 29044047)
    • (1999) Mutation Research - Reviews in Mutation Research , vol.436 , Issue.1 , pp. 69-97
    • Kuroda, Y.1    Hara, Y.2
  • 28
    • 0038171270 scopus 로고    scopus 로고
    • Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice
    • DOI 10.1023/A:1023863003093
    • R. Kurosaki, Y. Muramatsu, H. Watanabe, M. Michimata, M. Matsubara, Y. Imai, and T. Araki Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice Metab. Brain Dis. 18 2003 139 146 (Pubitemid 36718126)
    • (2003) Metabolic Brain Disease , vol.18 , Issue.2 , pp. 139-146
    • Kurosaki, R.1    Muramatsu, Y.2    Watanabe, H.3    Michimata, M.4    Matsubara, M.5    Imai, Y.6    Araki, T.7
  • 29
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • J.W. Langston, P. Ballard, J.W. Tetrud, and I. Irwin Chronic parkinsonism in humans due to a product of meperidine-analog synthesis Science 219 1983 979 980 (Pubitemid 13189531)
    • (1983) Science , vol.219 , Issue.4587 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 30
    • 21444451858 scopus 로고    scopus 로고
    • MPTP treatment in mice does not transmit and cause Parkinsonian neurotoxicity in non-treated cagemates through close contact
    • DOI 10.1016/j.neures.2005.04.010, PII S0168010205001240
    • Y.S. Lau, L. Novikova, and C. Roels MPTP treatment in mice does not transmit and cause Parkinsonian neurotoxicity in non treated cagemates through close contact Neurosci. Res. 52 2005 371 378 (Pubitemid 40917216)
    • (2005) Neuroscience Research , vol.52 , Issue.4 , pp. 371-378
    • Lau, Y.-S.1    Novikova, L.2    Roels, C.3
  • 31
    • 79953292347 scopus 로고    scopus 로고
    • Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration
    • Y.S. Lau, G. Patki, K. Das-Panja, W.D. Le, and S.O. Ahmad Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration Eur. J. Neurosci. 33 2011 1264 1274
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 1264-1274
    • Lau, Y.S.1    Patki, G.2    Das-Panja, K.3    Le, W.D.4    Ahmad, S.O.5
  • 32
    • 0034856072 scopus 로고    scopus 로고
    • Theaflavins in black tea and catechins in green tea are equally effective antioxidants
    • L.K. Leung, Y. Su, R. Chen, Z. Zhang, Y. Huang, and Z.Y. Chen Theaflavins in black tea and catechins in green tea are equally effective antioxidants J. Nutr. 131 2001 2248 2251 (Pubitemid 32851864)
    • (2001) Journal of Nutrition , vol.131 , Issue.9 , pp. 2248-2251
    • Leung, L.K.1    Su, Y.2    Chen, R.3    Zhang, Z.4    Huang, Y.5    Chen, Z.-Y.6
  • 33
    • 0034851553 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
    • DOI 10.1046/j.1471-4159.2001.00490.x
    • Y. Levites, O. Weinreb, G. Maor, M.B. Youdim, and S. Mandel Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced dopaminergic neurodegeneration J. Neurochem. 78 2001 1073 1082 (Pubitemid 32823156)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.5 , pp. 1073-1082
    • Levites, Y.1    Weinreb, O.2    Maor, G.3    Youdim, M.B.H.4    Mandel, S.5
  • 34
    • 0036145435 scopus 로고    scopus 로고
    • Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures
    • DOI 10.1016/S0006-2952(01)00813-9, PII S0006295201008139
    • Y. Levites, M.B. Youdim, G. Maor, and S. Mandel Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures Biochem. Pharmacol. 63 2002 21 29 (Pubitemid 34075289)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.1 , pp. 21-29
    • Levites, Y.1    Youdim, M.B.H.2    Maor, G.3    Mandel, S.4
  • 35
    • 80051512571 scopus 로고    scopus 로고
    • Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine-Induced Mouse Model of Parkinson's Disease
    • S. Li, and X.P. Pu Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease Biol. Pharm. Bull. 34 2011 1291 1296
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1291-1296
    • Li, S.1    Pu, X.P.2
  • 36
    • 39049145972 scopus 로고    scopus 로고
    • Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity
    • DOI 10.1016/j.cellbi.2007.08.016, PII S1065699507002144
    • B. Liu, J.X. Xie, L.L. Tsang, D.K. Rowlands, L.S. Ho, Y.L. Gou, Y.W. Chung, and H.C. Chan Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity Cell Biol. Int. 32 2008 86 92 (Pubitemid 351249143)
    • (2008) Cell Biology International , vol.32 , Issue.1 , pp. 86-92
    • Liu, B.1    Xie, J.X.2    Tsang, L.L.3    Rowlands, D.K.4    Ho, L.S.5    Gou, Y.L.6    Chung, Y.W.7    Chan, H.C.8
  • 38
    • 13844271390 scopus 로고    scopus 로고
    • Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: Investigations in primary rat mesencephalic cultures
    • DOI 10.1016/j.bcp.2004.09.018
    • L.D. Mercer, B.L. Kelly, M.K. Horne, and P.M. Beart Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures Biochem. Pharmacol. 69 2005 339 345 (Pubitemid 41556580)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.2 , pp. 339-345
    • Mercer, L.D.1    Kelly, B.L.2    Horne, M.K.3    Beart, P.M.4
  • 39
    • 33750503773 scopus 로고    scopus 로고
    • Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice
    • DOI 10.1016/j.jns.2006.06.018, PII S0022510X06002954
    • M. Mohanasundari, M.S. Srinivasan, S. Sethupathy, and M. Sabesan Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice J. Neurol. Sci. 249 2006 140 144 (Pubitemid 44665916)
    • (2006) Journal of the Neurological Sciences , vol.249 , Issue.2 , pp. 140-144
    • Mohanasundari, M.1    Srinivasan, M.S.2    Sethupathy, S.3    Sabesan, M.4
  • 40
    • 33747889995 scopus 로고    scopus 로고
    • Glutamate-induced cell death and formation of radicals can be reduced by lisuride in mesencephalic primary cell culture
    • DOI 10.1007/s00702-005-0394-1
    • R. Moldzio, K. Radad, J.C. Duvigneau, B. Kranner, C. Krewenka, C. Piskernik, and W.D. Rausch Glutamate-induced cell death and formation of radicals can be reduced by lisuride in mesencephalic primary cell culture J. Neural Transm. 113 2006 1095 1105 (Pubitemid 44291006)
    • (2006) Journal of Neural Transmission , vol.113 , Issue.9 , pp. 1095-1105
    • Moldzio, R.1    Radad, K.2    Duvigneau, J.C.3    Kranner, B.4    Krewenka, C.5    Piskernik, C.6    Rausch, W.D.7
  • 41
    • 0035960066 scopus 로고    scopus 로고
    • Mouse model of Parkinsonism: A comparison between subacute MPTP and chronic MPTP/probenecid treatment
    • DOI 10.1016/S0306-4522(01)00295-0, PII S0306452201002950
    • E. Petroske, G.E. Meredith, S. Callen, S. Totterdell, and Y.S. Lau Mouse model of parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment Neuroscience 106 2001 589 601 (Pubitemid 32925247)
    • (2001) Neuroscience , vol.106 , Issue.3 , pp. 589-601
    • Petroske, E.1    Meredith, G.E.2    Callen, S.3    Totterdell, S.4    Lau, Y.-S.5
  • 42
    • 0037713489 scopus 로고    scopus 로고
    • The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: A tool to explore the pathogenesis of Parkinson's disease
    • S. Przedborski, and M. Vila The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease Ann. N. Y. Acad. Sci. 991 2003 189 198 (Pubitemid 36793814)
    • (2003) Annals of the New York Academy of Sciences , vol.991 , pp. 189-198
    • Przedborski, S.1    Vila, M.2
  • 43
    • 62349087989 scopus 로고    scopus 로고
    • Ashwagandha leaf extract: A potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease
    • S. RajaSankar, T. Manivasagam, and S. Surendran Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease Neurosci. Lett. 454 2009 11 15
    • (2009) Neurosci. Lett. , vol.454 , pp. 11-15
    • Rajasankar, S.1    Manivasagam, T.2    Surendran, S.3
  • 44
    • 0023001744 scopus 로고
    • Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria
    • R.R. Ramsay, and T.P. Singer Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine, by mitochondria J. Biol. Chem. 261 1986 7585 7587 (Pubitemid 17208669)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.17 , pp. 7585-7587
    • Ramsay, R.R.1    Singer, T.P.2
  • 45
    • 0023833858 scopus 로고
    • Tyrosine hydroxylase activity in caudate nucleus from Parkinson's disease: Effects of iron and phosphorylating agents
    • W.D. Rausch, Y. Hirata, T. Nagatsu, P. Riederer, and K. Jellinger Tyrosine hydroxylase activity in caudate nucleus from Parkinson's disease, effects of iron and phosphorylating agents J. Neurochem. 50 1988 202 208 (Pubitemid 18023500)
    • (1988) Journal of Neurochemistry , vol.50 , Issue.1 , pp. 202-208
    • Rausch, W.-D.1    Hirata, Y.2    Nagatsu, T.3    Riederer, P.4    Jellinger, K.5
  • 46
    • 0032168609 scopus 로고    scopus 로고
    • The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism
    • DOI 10.1016/S0165-0270(98)00078-8, PII S0165027098000788
    • G. Rozas, E. Lopez-Martin, M.J. Guerra, and J.L. Labandeira-Garcia The overall rod performance test in the MPTP-treated mouse model of Parkinsonism J. Neurosci. Methods 83 1998 165 175 (Pubitemid 28442608)
    • (1998) Journal of Neuroscience Methods , vol.83 , Issue.2 , pp. 165-175
    • Rozas, G.1    Lopez-Martin, E.2    Guerra, M.J.3    Labandeira-Garcia, J.L.4
  • 47
    • 0023187166 scopus 로고
    • Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP
    • DOI 10.1016/0006-8993(87)90691-3
    • J.S. Schneider, A. Yuwiler, and C.H. Markham Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP Brain Res. 411 1987 144 150 (Pubitemid 17084779)
    • (1987) Brain Research , vol.411 , Issue.1 , pp. 144-150
    • Schneider, J.S.1    Yuwiler, A.2    Markham, C.H.3
  • 48
    • 0033749345 scopus 로고    scopus 로고
    • MPTP susceptivility in the mouse: Behavioral, neurochemical, and histological analysis of gender and strain differences
    • M. Sedelis, K. Hofele, G.W. Auburger, S. Morgan, J.P. Huston, and R.K. Schwarting MPTP susceptivility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences Behav. Genet. 30 2000 171 182
    • (2000) Behav. Genet. , vol.30 , pp. 171-182
    • Sedelis, M.1    Hofele, K.2    Auburger, G.W.3    Morgan, S.4    Huston, J.P.5    Schwarting, R.K.6
  • 49
    • 15844397278 scopus 로고    scopus 로고
    • Neurotoxins and neurotoxic species implicated in neurodegeneration
    • J. Segura Aguilar, and R.M. Kostrzewa Neurotoxins and neurotoxic species implicated in neurodegeneration Neurotox. Res. 6 2004 615 630
    • (2004) Neurotox. Res. , vol.6 , pp. 615-630
    • Segura Aguilar, J.1    Kostrzewa, R.M.2
  • 50
    • 79959884176 scopus 로고    scopus 로고
    • A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease
    • (Epub 2011 Jun 29)
    • A. Seidi, H. Kaji, N. Annabi, S. Ostrovidov, M. Ramalingam, and A. Khademhosseini A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease Biomicrofluidics 2 2011 22214 (Epub 2011 Jun 29)
    • (2011) Biomicrofluidics , vol.2 , pp. 22214
    • Seidi, A.1    Kaji, H.2    Annabi, N.3    Ostrovidov, S.4    Ramalingam, M.5    Khademhosseini, A.6
  • 52
    • 43549083894 scopus 로고    scopus 로고
    • MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation - Relevance in a mouse model of Parkinson's disease
    • DOI 10.1111/j.1471-4159.2008.05310.x
    • T. Thomas, M. Timmer, K. Cesnulevicius, E. Hitti, A. Kotlyarov, and M. Gaestel MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation-relevance in a mouse model of Parkinson's disease J. Neurochem. 105 2008 2039 2052 (Pubitemid 351678515)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.5 , pp. 2039-2052
    • Thomas, T.1    Timmer, M.2    Cesnulevicius, K.3    Hitti, E.4    Kotlyarov, A.5    Gaestel, M.6
  • 53
    • 0036315556 scopus 로고    scopus 로고
    • Treatment options for Parkinson's disease
    • DOI 10.1097/00019052-200208000-00011
    • R. Tinter, and J. Jankovic Treatment options for Parkinson's disease Curr. Opin. Neurol. 15 2002 467 476 (Pubitemid 34828125)
    • (2002) Current Opinion in Neurology , vol.15 , Issue.4 , pp. 467-476
    • Tintner, R.1    Jankovic, J.2
  • 54
    • 0035894881 scopus 로고    scopus 로고
    • Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    • V. Viswanath, Y.Q. Wu, R. Boonplueang, S. Chen, F.F. Stevenson, F. Yantiri, L.C. Yang, M.F. Beal, and J.K. Andersen Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1 2,3,6-tetrahydropyridine-induced Parkinson's disease J. Neurosci. 21 2001 9519 9528 (Pubitemid 34184040)
    • (2001) Journal of Neuroscience , vol.21 , Issue.24 , pp. 9519-9528
    • Viswanath, V.1    Wu, Y.2    Boonplueang, R.3    Chen, S.4    Stevenson, F.F.5    Yantiri, F.6    Yang, L.7    Flint Beal, M.8    Andersen, J.K.9
  • 55
    • 12244300931 scopus 로고    scopus 로고
    • Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease
    • Y. Watanabe, T. Himeda, and T. Araki Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease Med. Sci. Monit. 11 2005 17 23
    • (2005) Med. Sci. Monit. , vol.11 , pp. 17-23
    • Watanabe, Y.1    Himeda, T.2    Araki, T.3
  • 56
    • 0032579840 scopus 로고    scopus 로고
    • Effects of haloperidol metabolites on neurotransmitter uptake and release: Possible role in neurotoxicity and tardive dyskinesia
    • DOI 10.1016/S0006-8993(97)01551-5, PII S0006899397015515
    • A.M. Wright, J. Bempong, M.L. Kirby, R.L. Barlow, and J.R. Bloomquist Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia Brain Res. 788 1998 215 222 (Pubitemid 28202164)
    • (1998) Brain Research , vol.788 , Issue.1-2 , pp. 215-222
    • Wright, A.M.1    Bempong, J.2    Kirby, M.L.3    Barlow, R.L.4    Bloomquist, J.R.5


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