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Volumn 105, Issue 5, 2008, Pages 2039-2052

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation - Relevance in a mouse model of Parkinson's disease

Author keywords

Ablation; Inflammation; Neurodegeneration; Parkinson's disease; Protein kinases

Indexed keywords

LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

EID: 43549083894     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05310.x     Document Type: Article
Times cited : (70)

References (57)
  • 1
    • 0035124607 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
    • Barone F. C., Irving E. A., Ray A. M. et al. (2001) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Med. Res. Rev. 21, 129 145.
    • (2001) Med. Res. Rev. , vol.21 , pp. 129-145
    • Barone, F.C.1    Irving, E.A.2    Ray, A.M.3
  • 2
    • 0037119464 scopus 로고    scopus 로고
    • P38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2
    • Bhat N. R., Feinstein D. L., Shen Q. Bhat A. N. (2002) p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2. J. Biol. Chem. 277, 29584 29592.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29584-29592
    • Bhat, N.R.1    Feinstein, D.L.2    Shen, Q.3    Bhat, A.N.4
  • 3
    • 0027197996 scopus 로고
    • Neuroprotective role of IL-4 against activated microglia
    • Chao C. C., Molitor T. W. Hu S. (1993) Neuroprotective role of IL-4 against activated microglia. J. Immunol. 151, 1473 1481.
    • (1993) J. Immunol. , vol.151 , pp. 1473-1481
    • Chao, C.C.1    Molitor, T.W.2    Hu, S.3
  • 4
    • 0035900675 scopus 로고    scopus 로고
    • P38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells
    • Cheng A., Chan S. L., Milhavet O., Wang S. Mattson M. P. (2001) p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells. J. Biol. Chem. 276, 43320 43327.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43320-43327
    • Cheng, A.1    Chan, S.L.2    Milhavet, O.3    Wang, S.4    Mattson, M.P.5
  • 5
    • 2442502511 scopus 로고    scopus 로고
    • Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons
    • Choi W. S., Eom D. S., Han B. S., Kim W. K., Han B. H., Choi E. J., Oh T. H., Markelonis G. J., Cho J. W. Oh Y. J. (2004) Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J. Biol. Chem. 279, 20451 20460.
    • (2004) J. Biol. Chem. , vol.279 , pp. 20451-20460
    • Choi, W.S.1    Eom, D.S.2    Han, B.S.3    Kim, W.K.4    Han, B.H.5    Choi, E.J.6    Oh, T.H.7    Markelonis, G.J.8    Cho, J.W.9    Oh, Y.J.10
  • 6
    • 0038538477 scopus 로고    scopus 로고
    • Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38
    • Clark A. R., Dean J. L. Saklatvala J. (2003) Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546, 37 44.
    • (2003) FEBS Lett. , vol.546 , pp. 37-44
    • Clark, A.R.1    Dean, J.L.2    Saklatvala, J.3
  • 7
    • 33747632142 scopus 로고    scopus 로고
    • MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
    • Culbert A. A., Skaper S. D., Howlett D. R., Evans N. A., Facci L., Soden P. E., Seymour Z. M., Guillot F., Gaestel M. Richardson J. C. (2006) MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J. Biol. Chem. 281, 23658 23667.
    • (2006) J. Biol. Chem. , vol.281 , pp. 23658-23667
    • Culbert, A.A.1    Skaper, S.D.2    Howlett, D.R.3    Evans, N.A.4    Facci, L.5    Soden, P.E.6    Seymour, Z.M.7    Guillot, F.8    Gaestel, M.9    Richardson, J.C.10
  • 8
    • 0030712362 scopus 로고    scopus 로고
    • Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes
    • Da Silva J., Pierrat B., Mary J. L. Lesslauer W. (1997) Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272, 28373 28380.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28373-28380
    • Da Silva, J.1    Pierrat, B.2    Mary, J.L.3    Lesslauer, W.4
  • 9
    • 3142546235 scopus 로고    scopus 로고
    • The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
    • Dean J. L., Sully G., Clark A. R. Saklatvala J. (2004) The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell. Signal. 16, 1113 1121.
    • (2004) Cell. Signal. , vol.16 , pp. 1113-1121
    • Dean, J.L.1    Sully, G.2    Clark, A.R.3    Saklatvala, J.4
  • 10
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y., Ma Z., Lin S. et al. (2001) Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc. Natl Acad. Sci. USA 98, 14669 14674.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3
  • 12
    • 2542475349 scopus 로고    scopus 로고
    • Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum
    • Ferger B., Leng A., Mura A., Hengerer B. Feldon J. (2004) Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum. J. Neurochem. 89, 822 833.
    • (2004) J. Neurochem. , vol.89 , pp. 822-833
    • Ferger, B.1    Leng, A.2    Mura, A.3    Hengerer, B.4    Feldon, J.5
  • 13
    • 0029664477 scopus 로고    scopus 로고
    • CD14 mediate endotoxin induction of nitric oxide synthase in cultured brain glial cells
    • Galea E., Reis D. J., Fox E. S., Xu H. Feinstein D. L. (1996) CD14 mediate endotoxin induction of nitric oxide synthase in cultured brain glial cells. J. Neuroimmunol. 64, 19 28.
    • (1996) J. Neuroimmunol. , vol.64 , pp. 19-28
    • Galea, E.1    Reis, D.J.2    Fox, E.S.3    Xu, H.4    Feinstein, D.L.5
  • 14
    • 0038044029 scopus 로고    scopus 로고
    • Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    • Gao H. M., Liu B. Hong J. S. (2003) Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 23, 6181 6187.
    • (2003) J. Neurosci. , vol.23 , pp. 6181-6187
    • Gao, H.M.1    Liu, B.2    Hong, J.S.3
  • 16
    • 0032919249 scopus 로고    scopus 로고
    • An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons
    • Harada J. Sugimoto M. (1999) An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons. Jpn. J. Pharmacol. 79, 369 378.
    • (1999) Jpn. J. Pharmacol. , vol.79 , pp. 369-378
    • Harada, J.1    Sugimoto, M.2
  • 17
    • 0035895994 scopus 로고    scopus 로고
    • Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons
    • Harding T. C., Xue L., Bienemann A., Haywood D., Dickens M., Tolkovsky A. M. Uney J. B. (2001) Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons. J. Biol. Chem. 276, 4531 4534.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4531-4534
    • Harding, T.C.1    Xue, L.2    Bienemann, A.3    Haywood, D.4    Dickens, M.5    Tolkovsky, A.M.6    Uney, J.B.7
  • 18
    • 33644753147 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
    • Hitti E., Iakovleva T., Brook M., Deppenmeier S., Gruber A. D., Radzioch D., Clark A. R., Blackshear P. J., Kotlyarov A. Gaestel M. (2006) Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol. Cell. Biol. 26, 2399 2407.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 2399-2407
    • Hitti, E.1    Iakovleva, T.2    Brook, M.3    Deppenmeier, S.4    Gruber, A.D.5    Radzioch, D.6    Clark, A.R.7    Blackshear, P.J.8    Kotlyarov, A.9    Gaestel, M.10
  • 19
    • 0036275058 scopus 로고    scopus 로고
    • P38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures
    • Jeohn G. H., Cooper C. L., Wilson B., Chang R. C., Jang K. J., Kim H. C., Liu B. Hong J. S. (2002) p38 MAP kinase is involved in lipopolysaccharide- induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures. Ann. NY Acad. Sci. 962, 332 346.
    • (2002) Ann. NY Acad. Sci. , vol.962 , pp. 332-346
    • Jeohn, G.H.1    Cooper, C.L.2    Wilson, B.3    Chang, R.C.4    Jang, K.J.5    Kim, H.C.6    Liu, B.7    Hong, J.S.8
  • 20
    • 3843051149 scopus 로고    scopus 로고
    • Regulatory roles of JNK in programmed cell death
    • Kanda H. Miura M. (2004) Regulatory roles of JNK in programmed cell death. J. Biochem. 136, 1 6.
    • (2004) J. Biochem. , vol.136 , pp. 1-6
    • Kanda, H.1    Miura, M.2
  • 21
    • 0037121941 scopus 로고    scopus 로고
    • Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
    • Kontoyiannis D., Boulougouris G., Manoloukos M. et al. (2002) Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J. Exp. Med. 196, 1563 1574.
    • (2002) J. Exp. Med. , vol.196 , pp. 1563-1574
    • Kontoyiannis, D.1    Boulougouris, G.2    Manoloukos, M.3
  • 24
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
    • Lee S. C., Liu W., Dickson D. W., Brosnan C. F. Berman J. W. (1993) Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J. Immunol. 150, 2659 2667.
    • (1993) J. Immunol. , vol.150 , pp. 2659-2667
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Berman, J.W.5
  • 25
    • 7244242682 scopus 로고    scopus 로고
    • Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures
    • Lee S. M., Yune T. Y., Kim S. J., Kim Y. C., Oh Y. J., Markelonis G. J. Oh T. H. (2004) Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J. Neurochem. 91, 568 578.
    • (2004) J. Neurochem. , vol.91 , pp. 568-578
    • Lee, S.M.1    Yune, T.Y.2    Kim, S.J.3    Kim, Y.C.4    Oh, Y.J.5    Markelonis, G.J.6    Oh, T.H.7
  • 26
    • 0036569435 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection
    • Lehner M. D., Schwoebel F., Kotlyarov A., Leist M., Gaestel M. Hartung T. (2002) Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. J. Immunol. 168, 4667 4673.
    • (2002) J. Immunol. , vol.168 , pp. 4667-4673
    • Lehner, M.D.1    Schwoebel, F.2    Kotlyarov, A.3    Leist, M.4    Gaestel, M.5    Hartung, T.6
  • 28
    • 0034015558 scopus 로고    scopus 로고
    • Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    • Liu B., Du L. Hong J. S. (2000) Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J. Pharmacol. Exp. Ther. 293, 607 617.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 607-617
    • Liu, B.1    Du, L.2    Hong, J.S.3
  • 29
    • 0031874792 scopus 로고    scopus 로고
    • Inflammation in the CNS: Balance between immunological privilege and immune responses
    • Matyszak M. K. (1998) Inflammation in the CNS: balance between immunological privilege and immune responses. Prog. Neurobiol. 56, 19 35.
    • (1998) Prog. Neurobiol. , vol.56 , pp. 19-35
    • Matyszak, M.K.1
  • 30
    • 0034281386 scopus 로고    scopus 로고
    • Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
    • Namgung U. Xia Z. (2000) Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20, 6442 6451.
    • (2000) J. Neurosci. , vol.20 , pp. 6442-6451
    • Namgung, U.1    Xia, Z.2
  • 31
    • 0036479125 scopus 로고    scopus 로고
    • MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
    • Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H. D., Holtmann H., Kollias G. Gaestel M. (2002) MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J. Biol. Chem. 277, 3065 3068.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3065-3068
    • Neininger, A.1    Kontoyiannis, D.2    Kotlyarov, A.3    Winzen, R.4    Eckert, R.5    Volk, H.D.6    Holtmann, H.7    Kollias, G.8    Gaestel, M.9
  • 32
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Olanow C. W. Tatton W. G. (1999) Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22, 123 144.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 33
    • 14644446028 scopus 로고    scopus 로고
    • 2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids
    • 2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids. Mol. Cell. Neurosci. 28, 452 461.
    • (2005) Mol. Cell. Neurosci. , vol.28 , pp. 452-461
    • Onyango, I.G.1    Tuttle, J.B.2    Bennett Jr., J.P.3
  • 34
    • 0029942444 scopus 로고    scopus 로고
    • Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: A stereological study using the cavalieri and optical disector methods
    • Oorschot D. E. (1996) Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methods. J. Comp. Neurol. 366, 580 599.
    • (1996) J. Comp. Neurol. , vol.366 , pp. 580-599
    • Oorschot, D.E.1
  • 35
    • 33644958235 scopus 로고    scopus 로고
    • Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells
    • Ouyang M. Shen X. (2006) Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J. Neurochem. 97, 234 244.
    • (2006) J. Neurochem. , vol.97 , pp. 234-244
    • Ouyang, M.1    Shen, X.2
  • 36
    • 0025964041 scopus 로고
    • The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
    • Pakkenberg B., Moller A., Gundersen H. J., Mouritzen Dam A. Pakkenberg H. (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J. Neurol. Neurosurg. Psychiatr. 54, 30 33.
    • (1991) J. Neurol. Neurosurg. Psychiatr. , vol.54 , pp. 30-33
    • Pakkenberg, B.1    Moller, A.2    Gundersen, H.J.3    Mouritzen Dam, A.4    Pakkenberg, H.5
  • 37
    • 0033771987 scopus 로고    scopus 로고
    • Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
    • Possel H., Noack H., Putzke J., Wolf G. Sies H. (2000) Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32, 51 59.
    • (2000) Glia , vol.32 , pp. 51-59
    • Possel, H.1    Noack, H.2    Putzke, J.3    Wolf, G.4    Sies, H.5
  • 38
    • 0029984860 scopus 로고    scopus 로고
    • Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    • Przedborski S., Jackson-Lewis V., Yokoyama R., Shibata T., Dawson V. L. Dawson T. M. (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc. Natl Acad. Sci. USA 93, 4565 4571.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4565-4571
    • Przedborski, S.1    Jackson-Lewis, V.2    Yokoyama, R.3    Shibata, T.4    Dawson, V.L.5    Dawson, T.M.6
  • 39
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    • Qin L., Liu Y., Wang T., Wei S. J., Block M. L., Wilson B., Liu B. Hong J. S. (2004) NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem. 279, 1415 1421.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6    Liu, B.7    Hong, J.S.8
  • 40
    • 0034714259 scopus 로고    scopus 로고
    • Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR
    • Rodriguez-Pascual F., Hausding M., Ihrig-Biedert I., Furneaux H., Levy A. P., Forstermann U. Kleinert H. (2000) Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J. Biol. Chem. 275, 26040 26049.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26040-26049
    • Rodriguez-Pascual, F.1    Hausding, M.2    Ihrig-Biedert, I.3    Furneaux, H.4    Levy, A.P.5    Forstermann, U.6    Kleinert, H.7
  • 41
    • 0030972777 scopus 로고    scopus 로고
    • Astrogliosis in the neonatal and adult murine brain post-trauma: Elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma
    • Rostworowski M., Balasingam V., Chabot S., Owens T. Yong V. W. (1997) Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma. J. Neurosci. 17, 3664 3674.
    • (1997) J. Neurosci. , vol.17 , pp. 3664-3674
    • Rostworowski, M.1    Balasingam, V.2    Chabot, S.3    Owens, T.4    Yong, V.W.5
  • 42
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T. Nebreda A. R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027 1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 43
    • 33745269269 scopus 로고    scopus 로고
    • Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection
    • Ruano D., Revilla E., Gavilan M. P., Vizuete M. L., Pintado C., Vitorica J. Castano A. (2006) Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection. Neuroscience 140, 1157 1168.
    • (2006) Neuroscience , vol.140 , pp. 1157-1168
    • Ruano, D.1    Revilla, E.2    Gavilan, M.P.3    Vizuete, M.L.4    Pintado, C.5    Vitorica, J.6    Castano, A.7
  • 44
    • 0028364659 scopus 로고
    • Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue
    • Shohami E., Novikov M., Bass R., Yamin A. Gallily R. (1994) Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. J. Cereb. Blood Flow Metab. 14, 615 619.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 615-619
    • Shohami, E.1    Novikov, M.2    Bass, R.3    Yamin, A.4    Gallily, R.5
  • 45
    • 0141672049 scopus 로고    scopus 로고
    • P38 MAP kinase is activated at early stages in Alzheimer's disease brain
    • Sun A., Liu M., Nguyen X. V. Bing G. (2003) P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp. Neurol. 183, 394 405.
    • (2003) Exp. Neurol. , vol.183 , pp. 394-405
    • Sun, A.1    Liu, M.2    Nguyen, X.V.3    Bing, G.4
  • 47
    • 33846436077 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion
    • Timmer M., Cesnulevicius K., Winkler C., Kolb J., Lipokatic-Takacs E., Jungnickel J. Grothe C. (2007) Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J. Neurosci. 27, 459 471.
    • (2007) J. Neurosci. , vol.27 , pp. 459-471
    • Timmer, M.1    Cesnulevicius, K.2    Winkler, C.3    Kolb, J.4    Lipokatic-Takacs, E.5    Jungnickel, J.6    Grothe, C.7
  • 48
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton K. F. Singer T. P. (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61, 1191 1206.
    • (1993) J. Neurochem. , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 49
    • 33748743781 scopus 로고    scopus 로고
    • Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress
    • Vertii A., Hakim C., Kotlyarov A. Gaestel M. (2006) Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress. J. Biol. Chem. 281, 26966 26975.
    • (2006) J. Biol. Chem. , vol.281 , pp. 26966-26975
    • Vertii, A.1    Hakim, C.2    Kotlyarov, A.3    Gaestel, M.4
  • 50
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: Experimental and clinical evidence
    • Vezzani A. Granata T. (2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46, 1724 1743.
    • (2005) Epilepsia , vol.46 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 52
    • 16244367423 scopus 로고    scopus 로고
    • Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables
    • Volk H., Potschka H. Loscher W. (2005) Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J. Histochem. Cytochem. 53, 517 531.
    • (2005) J. Histochem. Cytochem. , vol.53 , pp. 517-531
    • Volk, H.1    Potschka, H.2    Loscher, W.3
  • 53
    • 0037113928 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
    • Wang X., Xu L., Wang H., Young P. R., Gaestel M. Feuerstein G. Z. (2002) Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. J. Biol. Chem. 277, 43968 43972.
    • (2002) J. Biol. Chem. , vol.277 , pp. 43968-43972
    • Wang, X.1    Xu, L.2    Wang, H.3    Young, P.R.4    Gaestel, M.5    Feuerstein, G.Z.6
  • 54
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West M. J. Gundersen H. J. (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp. Neurol. 296, 1 22.
    • (1990) J. Comp. Neurol. , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.2
  • 55
    • 0037366093 scopus 로고    scopus 로고
    • Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: Implications for Parkinson's disease
    • Wilms H., Rosenstiel P., Sievers J., Deuschl G., Zecca L. Lucius R. (2003) Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease. FASEB J. 17, 500 502.
    • (2003) FASEB J. , vol.17 , pp. 500-502
    • Wilms, H.1    Rosenstiel, P.2    Sievers, J.3    Deuschl, G.4    Zecca, L.5    Lucius, R.6
  • 56
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D. C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D. K., Ischiropoulos H. Przedborski S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 22, 1763 1771.
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 57
    • 0035895961 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons
    • Yamagishi S., Yamada M., Ishikawa Y., Matsumoto T., Ikeuchi T. Hatanaka H. (2001) p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. J. Biol. Chem. 276, 5129 5133.
    • (2001) J. Biol. Chem. , vol.276 , pp. 5129-5133
    • Yamagishi, S.1    Yamada, M.2    Ishikawa, Y.3    Matsumoto, T.4    Ikeuchi, T.5    Hatanaka, H.6


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