Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2550-2557

  Xue, Na ^a,b   Yang, Xiaochun ^a   Wu, Rui ^a   Chen, Jing ^a   He, Qiaojun ^a   Yang, Bo ^a   Lu, Xiuyang ^b   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Antitumor agents; Combretastatin A 4; Cytotoxicity; Imidazol 2 one derivatives; Synthesis

Indexed keywords

1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (2,4 DIFLUOROPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (2,4 DIMETHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (3 AMINO 4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (3 NITRO 4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 BROMOPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 CHLOROPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 NITROPHENYL) 2H IMIDAZOL 2 ONE; 1 ACETYL 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 PHENYL 2H IMIDAZOL 2 ONE; 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (3 AMINO 4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (3 NITRO 4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (3,4 DIMETHOXYPHENYL) 2H IMIDAZOL 2 ONE; 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 HYDROXYPHENYL) 2H IMIDAZOL 2 ONE; 1,3 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 4 (4 METHOXYPHENYL) 2H IMIDAZOL 2 ONE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (3 AMINO 4 METHOXYPHENYL) 2 OXO 1H IMIDAZOLE CARBOXAMIDE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (3 HYDROXY 4 METHOXYPHENYL) 2 OXO 1H IMIDAZOLE 1 CARBOXAMIDE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (3 NITRO 4 METHOXYPHENYL) 2 OXO 1H IMIDAZOLE 1 CARBOXAMIDE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (3,4 DIMETHOXYPHENYL) 2 OXO 1H IMIDAZOLE 1 CARBOXAMIDE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (4 HYDROXYPHENYL) 2 OXO 1H IMIDAZOLE 1 CARBOXAMIDE; 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 4 (4 METHOXYPHENYL) 2 OXO 1H IMIDAZOLE 1 CARBOXAMIDE; ANTINEOPLASTIC AGENT; COMBRETASTATIN A4; CYCLOPHOSPHAMIDE; DOCETAXEL; IMIDAZOL 2 ONE DERIVATIVE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; INDOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BROMINATION; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MODEL; CELL CYCLE ARREST; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEOPLASM; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749119680     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.048     Document Type: Article

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