Antineoplastic agents. 552. Oxidation of combretastatin A-1: Trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug

Journal of Natural Products

Volumn 71, Issue 9, 2008, Pages 1561-1563

  Pettit, George R ^a   Thornhill, Andrew J ^a   Moser, Bryan R ^a,b   Hogan, Fiona ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHOXY 4 [(3,4,5 TRIMETHOXYPHENYL)VINYL]PHENAZINE; 1,2 DIMETHOXY 4,5 DIAMINOBENZENE; 1,2 DIMETHOXY 4,5 DINITROBENZENE; 1,7,8 TRIMETHOXY 4 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]PHENAZINE; 3 METHOXY 6 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYLENE][1,2]BENZOQUINONE; BENZENE DERIVATIVE; COMBRETASTATIN A1 PHOSPHATE; PHENAZINE DERIVATIVE; PHENYLENEDIAMINE; QUINONE DERIVATIVE; TETRABUTYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; LEUKEMIA CELL; NONHUMAN; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL PRODUCTS; DRUG SCREENING ASSAYS, ANTITUMOR; LEUKEMIA P388; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PRODRUGS; QUINONES; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 54149093135     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np800179g     Document Type: Article

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