Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals

Chemical Research in Toxicology

Volumn 20, Issue 12, 2007, Pages 1885-1894

  Folkes, Lisa K ^a   Christlieb, Martin ^a   Madej, Edyta ^a   Stratford, Michael R L ^a   Wardman, Peter ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COMBRETASTATIN A1 PHOSPHATE; FREE RADICAL; GLUTATHIONE; HYDROQUINONE; QUINONE DERIVATIVE; SULFIDE; SUPEROXIDE DISMUTASE;

ABSORPTION SPECTROSCOPY; AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; AUTOOXIDATION; CATALYSIS; CELL STRAIN HL 60; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DRUG CONJUGATION; DRUG OXIDATION; ELECTRON SPIN RESONANCE; FEMALE; HUMAN; HUMAN CELL; LIVER; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PH; PULSE RADIOLYSIS; REDUCTION; RING CLOSING METATHESIS;

ANGIOGENESIS INHIBITORS; ANIMALS; ASCORBIC ACID; FEMALE; FREE RADICALS; GLUTATHIONE; HL-60 CELLS; HUMANS; METABOLIC DETOXICATION, PHASE I; MICE; MICE, INBRED CBA; NUCLEIC ACIDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN BINDING; QUINONES; STILBENES; SULFHYDRYL COMPOUNDS;

MUS;

EID: 38149097967     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx7002195     Document Type: Article

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