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Volumn 17, Issue 8, 2011, Pages 563-574

Mechanism of action of natural products used in the treatment of diabetes mellitus

Author keywords

Banaba; Bitter melon; Fenugreek; Ginseng; Hyperglycemia; Medicinal plants

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ANTIDIABETIC AGENT; BIGUANIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RH 2; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; INSULIN; LIRAGLUTIDE; MEGLITINIDE; METFORMIN; MIGLITOL; MUSCARINIC M3 RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PLANT MEDICINAL PRODUCT; PRAMLINTIDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REPAGLINIDE; SITAGLIPTIN; SULFONYLUREA; UNINDEXED DRUG; VANADIUM; BIOLOGICAL PRODUCT;

EID: 84855164123     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-011-0810-3     Document Type: Review
Times cited : (184)

References (96)
  • 1
    • 73949146152 scopus 로고    scopus 로고
    • Current views on type 2 diabetes
    • Lin Y, Sun Z. Current views on type 2 diabetes. J Endocrinol 2010;204:1-11.
    • (2010) J Endocrinol , vol.204 , pp. 1-11
    • Lin, Y.1    Sun, Z.2
  • 2
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-1431.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 3
    • 0037177592 scopus 로고    scopus 로고
    • Unraveling the causes of diabetes
    • Marx J. Unraveling the causes of diabetes. Science 2002;296:686-689.
    • (2002) Science , vol.296 , pp. 686-689
    • Marx, J.1
  • 5
    • 0035678809 scopus 로고    scopus 로고
    • An economic model of the long-term health care burden of type 2 diabetes
    • Bagust A, Hopkinson PK, Maier W, Currie CJ. An economic model of the long-term health care burden of type 2 diabetes. Diabetologia 2001;44:2140-2155.
    • (2001) Diabetologia , vol.44 , pp. 2140-2155
    • Bagust, A.1    Hopkinson, P.K.2    Maier, W.3    Currie, C.J.4
  • 6
    • 0031897103 scopus 로고    scopus 로고
    • Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. Adults. The third national health and nutrition examination survey, 1988-1994
    • Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 1998;21:518-524.
    • (1998) Diabetes Care , vol.21 , pp. 518-524
    • Harris, M.I.1    Flegal, K.M.2    Cowie, C.C.3    Eberhardt, M.S.4    Goldstein, D.E.5    Little, R.R.6
  • 9
    • 59849103075 scopus 로고    scopus 로고
    • A target based therapeutic approach towards diabetes mellitus using medicinal plants
    • Prabhakar PK, Doble M. A target based therapeutic approach towards diabetes mellitus using medicinal plants. Curr Diabetes Rev 2008;4:291-308.
    • (2008) Curr Diabetes Rev , vol.4 , pp. 291-308
    • Prabhakar, P.K.1    Doble, M.2
  • 10
    • 34447136762 scopus 로고    scopus 로고
    • Diabetes beyond insulin: Review of new drugs for treatment of diabetes mellitus
    • Modi P. Diabetes beyond insulin: review of new drugs for treatment of diabetes mellitus. Curr Drug Discov Technol 2007;4:39-47.
    • (2007) Curr Drug Discov Technol , vol.4 , pp. 39-47
    • Modi, P.1
  • 11
    • 21744440422 scopus 로고    scopus 로고
    • Structure and function studies of glucagon-like peptide-1 (GLP-1): The designing of a novel pharmacological agent for the treatment of diabetes
    • Hui H, Zhao X, Perfetti R. Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes. Diabetes Metab Res Rev 2005;21:313-331.
    • (2005) Diabetes Metab Res Rev , vol.21 , pp. 313-331
    • Hui, H.1    Zhao, X.2    Perfetti, R.3
  • 12
    • 51949116060 scopus 로고    scopus 로고
    • An overview of incretin clinical trials
    • Garber AJ, Spann SJ. An overview of incretin clinical trials. J Fam Pract 2008; 57(Suppl 9):S10-S18.
    • (2008) J Fam Pract , vol.57 , Issue.SUPPL.9
    • Garber, A.J.1    Spann, S.J.2
  • 13
    • 70350597038 scopus 로고    scopus 로고
    • Mechanism of action of medicinal plants towards diabetes mellitus-A review
    • Govil JN, Singh VK, Bhardwaj R, eds. LLC, USA: Studium Press
    • Prabhakar PK, Doble M. Mechanism of action of medicinal plants towards diabetes mellitus-A review. In: Govil JN, Singh VK, Bhardwaj R, eds. Recent progress in medicinal plants. Vol 22. LLC, USA: Studium Press; 2008:187-210.
    • (2008) Recent Progress in Medicinal Plants , vol.22 , pp. 187-210
    • Prabhakar, P.K.1    Doble, M.2
  • 14
    • 3042771527 scopus 로고    scopus 로고
    • Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death
    • Hui H, Dotta F, Di Mario U, Perfetti R. Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. J Cell Physiol 2004;200:177-200.
    • (2004) J Cell Physiol , vol.200 , pp. 177-200
    • Hui, H.1    Dotta, F.2    Di Mario, U.3    Perfetti, R.4
  • 15
    • 0037291184 scopus 로고    scopus 로고
    • Evaluation of antidiabetic effect of momordica cymbalaria fruit in alloxandiabetic rats
    • Kameswararao B, Kesavulu MM, Apparao C. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxandiabetic rats. Fitoterapia 2003;74:7-13.
    • (2003) Fitoterapia , vol.74 , pp. 7-13
    • Kameswararao, B.1    Kesavulu, M.M.2    Apparao, C.3
  • 16
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 17
    • 0002923091 scopus 로고    scopus 로고
    • Shifting the paradigm from conventional to alternative medicines: An introduction on traditional Indian medicines
    • Grover JK, Vats V. Shifting the paradigm from conventional to alternative medicines: an introduction on traditional Indian medicines. Asia Pacifi c Biotech News 2001;5:28-32.
    • (2001) Asia Pacifi C Biotech News , vol.5 , pp. 28-32
    • Grover, J.K.1    Vats, V.2
  • 18
    • 0034641542 scopus 로고    scopus 로고
    • Herbal medicines: Where is the evidence?
    • Ernst E. Herbal medicines: where is the evidence? BMJ 2000;321:395-396.
    • (2000) BMJ , vol.321 , pp. 395-396
    • Ernst, E.1
  • 21
    • 9744222928 scopus 로고    scopus 로고
    • Potential synergy of phytochemicals in cancer prevention: Mechanism of action
    • Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 2004;134 (Suppl 12):3479S-3485S.
    • (2004) J Nutr , vol.134 , Issue.SUPPL.12
    • Liu, R.H.1
  • 22
    • 0034296757 scopus 로고    scopus 로고
    • Antioxidative activity of (-)-epigallocatechin-3-(3"-O-methyl) gallate isolated from fresh tea leaf and preliminary results on its biological activity
    • Kawase M, Wang R, Shiomi T, Saijo R, Yagi K. Antioxidative activity of (-)-epigallocatechin-3-(3"-O-methyl) gallate isolated from fresh tea leaf and preliminary results on its biological activity. Biosci Biotechnol Biochem 2000;64:2218-2220.
    • (2000) Biosci Biotechnol Biochem , vol.64 , pp. 2218-2220
    • Kawase, M.1    Wang, R.2    Shiomi, T.3    Saijo, R.4    Yagi, K.5
  • 23
    • 55149111149 scopus 로고    scopus 로고
    • Korean red ginseng stimulates insulin release from isolated rat pancreatic islets
    • Kim K, Kim HY. Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. J Ethnopharmacol 2008;120:190-195.
    • (2008) J Ethnopharmacol , vol.120 , pp. 190-195
    • Kim, K.1    Kim, H.Y.2
  • 24
    • 33846980122 scopus 로고    scopus 로고
    • Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone
    • Kim EK, Kwon KB, Lee JH, Park BH, Park JW, Lee HK, et al. Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone. Biol Pharm Bull 2007;30:242-246.
    • (2007) Biol Pharm Bull , vol.30 , pp. 242-246
    • Kim, E.K.1    Kwon, K.B.2    Lee, J.H.3    Park, B.H.4    Park, J.W.5    Lee, H.K.6
  • 25
    • 0035380884 scopus 로고    scopus 로고
    • Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in kkay mice
    • Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res 2001;24:214-218.
    • (2001) Arch Pharm Res , vol.24 , pp. 214-218
    • Chung, S.H.1    Choi, C.G.2    Park, S.H.3
  • 26
    • 0034630423 scopus 로고    scopus 로고
    • American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus
    • Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan- Zdravkovic U, Xu Z, Vidgen E. American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-1013.
    • (2000) Arch Intern Med , vol.160 , pp. 1009-1013
    • Vuksan, V.1    Sievenpiper, J.L.2    Koo, V.Y.3    Francis, T.4    Beljan-, Z.U.5    Xu, Z.6    Vidgen, E.7
  • 27
    • 0029658414 scopus 로고    scopus 로고
    • Combined potentiating effects of Byakko-ka-ninjin-to, its constituents, rhizomes of Anemarrhena asphodeloides, timosaponin A-?, and calcium on pilocarpine-induced saliva secretion in streptozocindiabetic mice
    • Kimura M, Kimura I, Chem FJ. Combined potentiating effects of Byakko-ka-ninjin-to, its constituents, rhizomes of Anemarrhena asphodeloides, timosaponin A-?, and calcium on pilocarpine-induced saliva secretion in streptozocindiabetic mice. Biol Pharm Bull 1996;19:926-931.
    • (1996) Biol Pharm Bull , vol.19 , pp. 926-931
    • Kimura, M.1    Kimura, I.2    Chem, F.J.3
  • 28
    • 0347785479 scopus 로고    scopus 로고
    • Variable effects of American ginseng: A batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profi le does not affect postprandial glycemia
    • Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profi le does not affect postprandial glycemia. Eur J Clin Nutr 2003;57:243-248.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 243-248
    • Sievenpiper, J.L.1    Arnason, J.T.2    Leiter, L.A.3    Vuksan, V.4
  • 29
    • 34548684318 scopus 로고    scopus 로고
    • Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat
    • Banz WJ, Iqbal MJ, Bollaert M, Chickris N, James B, Higginbotham DA, et al. Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. Phytomedicine 2007;14:681-689.
    • (2007) Phytomedicine , vol.14 , pp. 681-689
    • Banz, W.J.1    Iqbal, M.J.2    Bollaert, M.3    Chickris, N.4    James, B.5    Higginbotham, D.A.6
  • 30
    • 36549049452 scopus 로고    scopus 로고
    • American ginseng modulates pancreatic beta cell activities
    • Wu Z, Luo JZ, Luo L. American ginseng modulates pancreatic beta cell activities. Chin Med 2007;2:11.
    • (2007) Chin Med , vol.2 , pp. 11
    • Wu, Z.1    Luo, J.Z.2    Luo, L.3
  • 31
    • 59449086814 scopus 로고    scopus 로고
    • Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways
    • Hwang JT, Lee MS, Kim HJ, Sung MJ, Kim HY, Kim MS, et al. Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Phytother Res 2009;23:262-266.
    • (2009) Phytother Res , vol.23 , pp. 262-266
    • Hwang, J.T.1    Lee, M.S.2    Kim, H.J.3    Sung, M.J.4    Kim, H.Y.5    Kim, M.S.6
  • 32
    • 33645083467 scopus 로고    scopus 로고
    • Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats
    • Lee WK, Kao ST, Liu IM, Cheng JT. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clin Exp Pharmacol Physiol 2006;33:27-32.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 27-32
    • Lee, W.K.1    Kao, S.T.2    Liu, I.M.3    Cheng, J.T.4
  • 33
    • 48749094892 scopus 로고    scopus 로고
    • A comparison of the ancient use of ginseng in traditional chinese medicine with modern pharmacological experiments and clinical trials
    • Xiang YZ, Shang HC, Gao XM, Zhang BL. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res 2008;22:851-858.
    • (2008) Phytother Res , vol.22 , pp. 851-858
    • Xiang, Y.Z.1    Shang, H.C.2    Gao, X.M.3    Zhang, B.L.4
  • 35
    • 3242813810 scopus 로고    scopus 로고
    • Does bitter melon contain an activator of AMP activated kinase?
    • McCarty MF. Does bitter melon contain an activator of AMPactivated kinase? Med Hypotheses 2004;63:340-343.
    • (2004) Med Hypotheses , vol.63 , pp. 340-343
    • McCarty, M.F.1
  • 36
    • 33746386763 scopus 로고    scopus 로고
    • Bitter gourd (Momordicacharantia): A dietary approach to hyperglycemia
    • Krawinkel MB, Keding GB. Bitter gourd (Momordicacharantia): a dietary approach to hyperglycemia. Nutr Rev 2006;64:331-337.
    • (2006) Nutr Rev , vol.64 , pp. 331-337
    • Krawinkel, M.B.1    Keding, G.B.2
  • 37
    • 33745685683 scopus 로고    scopus 로고
    • Momordica charantia constituents and antidiabetic screening of the isolated major compounds
    • Tokyo
    • Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, et al. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem Pharm Bull (Tokyo) 2006;54:1017-1021.
    • (2006) Chem Pharm Bull , vol.54 , pp. 1017-1021
    • Harinantenaina, L.1    Tanaka, M.2    Takaoka, S.3    Oda, M.4    Mogami, O.5    Uchida, M.6
  • 38
    • 0036886364 scopus 로고    scopus 로고
    • Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts
    • Rathi SS, Grover JK, Vikrant V, Biswas NR. Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. Phytother Res 2002;16:774-777.
    • (2002) Phytother Res , vol.16 , pp. 774-777
    • Rathi, S.S.1    Grover, J.K.2    Vikrant, V.3    Biswas, N.R.4
  • 39
    • 0027215565 scopus 로고
    • Hypoglycaemic activity of coccinia indica and momordica charantia in diabetic rats: Depression of the hepatic gluconeogenic enzymes glucose-6- phosphatase and fructose-1, 6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase
    • Shibib BA, Khan LA, Rahman R. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6- phosphatase and fructose-1, 6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993;292(Pt1):267-270.
    • (1993) Biochem J , vol.292 , Issue.PART1 , pp. 267-270
    • Shibib, B.A.1    Khan, L.A.2    Rahman, R.3
  • 40
    • 0347418244 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-Activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells
    • Chao CY, Huang C. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-Activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci 2003;10(6 Pt 2):782-791.
    • (2003) J Biomed Sci , vol.10 , Issue.6 PART 2 , pp. 782-791
    • Chao, C.Y.1    Huang, C.2
  • 41
    • 33845390582 scopus 로고    scopus 로고
    • Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPAR-Alpha in bitter gourd (Momordica charantia L.)
    • Chuang CY, Hsu C, Chao CY, Wein YS, Kuo YH, Huang CJ. Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPAR-Alpha in bitter gourd (Momordica charantia L.). J Biomed Sci 2006;13:763-772.
    • (2006) J Biomed Sci , vol.13 , pp. 763-772
    • Chuang, C.Y.1    Hsu, C.2    Chao, C.Y.3    Wein, Y.S.4    Kuo, Y.H.5    Huang, C.J.6
  • 42
    • 40749137409 scopus 로고    scopus 로고
    • Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
    • Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 2008;15:263-273.
    • (2008) Chem Biol , vol.15 , pp. 263-273
    • Tan, M.J.1    Ye, J.M.2    Turner, N.3    Hohnen-Behrens, C.4    Ke, C.Q.5    Tang, C.P.6
  • 44
    • 0037385896 scopus 로고    scopus 로고
    • Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet
    • Chen Q, Chan LL, Li ET. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr 2003;133:1088-1093.
    • (2003) J Nutr , vol.133 , pp. 1088-1093
    • Chen, Q.1    Chan, L.L.2    Li, E.T.3
  • 45
    • 47249156463 scopus 로고    scopus 로고
    • Ef f i cac y of dietar y supplementation with botanicals on carbohydrate metabolism in humans
    • Cefalu WT, Ye J, Wang ZQ. Ef f i cac y of dietar y supplementation with botanicals on carbohydrate metabolism in humans. Endocr Metab Immun Disord Drug Targets 2008;8:76-81.
    • (2008) Endocr Metab Immun Disord Drug Targets , vol.8 , pp. 76-81
    • Cefalu, W.T.1    Ye, J.2    Wang, Z.Q.3
  • 46
    • 78649441616 scopus 로고    scopus 로고
    • Insulin secretion and action
    • eds. (2nd ed). Humana Press
    • Yu R, Hui H, Shlomo M, eds. Insulin secretion and action. Endocrinology (2nd ed). Humana Press; 2005:311-319.
    • (2005) Endocrinology , pp. 311-319
    • Yu, R.1    Hui, H.2    Shlomo, M.3
  • 47
    • 33749336146 scopus 로고    scopus 로고
    • Berberine, a natural plant product, activates AMP-Activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    • Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-Activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006;55:2256-2264.
    • (2006) Diabetes , vol.55 , pp. 2256-2264
    • Lee, Y.S.1    Kim, W.S.2    Kim, K.H.3    Yoon, M.J.4    Cho, H.J.5    Shen, Y.6
  • 48
    • 45749144363 scopus 로고    scopus 로고
    • Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats
    • Zhou JY, Zhou SW, Zhang KB, Tang JL, Guang LX, Ying Y, et al. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull 2008;31:1169-1176.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1169-1176
    • Zhou, J.Y.1    Zhou, S.W.2    Zhang, K.B.3    Tang, J.L.4    Guang, L.X.5    Ying, Y.6
  • 49
    • 50449090523 scopus 로고    scopus 로고
    • Berberine acutely inhibits insulin secretion from beta-cells through 3', 5'-cyclic adenosine 5'-monophosphate signaling pathway
    • Zhou L, Wang X, Shao L, Yang Y, Shang W, Yuan G, et al. Berberine acutely inhibits insulin secretion from beta-cells through 3', 5'-cyclic adenosine 5'-monophosphate signaling pathway. Endocrinology 2008;149:4510-4518.
    • (2008) Endocrinology , vol.149 , pp. 4510-4518
    • Zhou, L.1    Wang, X.2    Shao, L.3    Yang, Y.4    Shang, W.5    Yuan, G.6
  • 50
    • 57049090579 scopus 로고    scopus 로고
    • Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression
    • Kong WJ, Zhang H, Song DQ, Xue R, Zhao W, Wei J, et al. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism 2009;58:109-119.
    • (2009) Metabolism , vol.58 , pp. 109-119
    • Kong, W.J.1    Zhang, H.2    Song, D.Q.3    Xue, R.4    Zhao, W.5    Wei, J.6
  • 51
    • 51149101181 scopus 로고    scopus 로고
    • Berberine ameliorates renal injury in streptopzotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase
    • Engl.
    • Liu WH, Hei ZQ, Nie H, Tang FT, Huang HQ, Li XJ, et al. Berberine ameliorates renal injury in streptopzotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chin Med J (Engl) 2008;121:706-712.
    • (2008) Chin Med J , vol.121 , pp. 706-712
    • Liu, W.H.1    Hei, Z.Q.2    Nie, H.3    Tang, F.T.4    Huang, H.Q.5    Li, X.J.6
  • 52
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex i: A mechanism for the action of berberine to activate AMPactivated protein kinase and improve insulin action
    • Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex i: a mechanism for the action of berberine to activate AMPactivated protein kinase and improve insulin action. Diabetes 2008;57:1414-1418.
    • (2008) Diabetes , vol.57 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6
  • 53
    • 42949145899 scopus 로고    scopus 로고
    • Effi cacy of berberine in patients with type 2 diabetes mellitus
    • Yin J, Xing H, Ye J. Effi cacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57:712-717.
    • (2008) Metabolism , vol.57 , pp. 712-717
    • Yin, J.1    Xing, H.2    Ye, J.3
  • 54
    • 47249158048 scopus 로고    scopus 로고
    • Traditional Chinese medicine in treatment of metabolic syndrome
    • Yin J, Zhang H, Ye J. Traditional Chinese medicine in treatment of metabolic syndrome. Endocr Metab Immun Disord Drug Targets 2008;8:99-111.
    • (2008) Endocr Metab Immun Disord Drug Targets , vol.8 , pp. 99-111
    • Yin, J.1    Zhang, H.2    Ye, J.3
  • 55
    • 0037674843 scopus 로고    scopus 로고
    • Antidiabetic activity of a standardized extract (GlucosolTM) from Lagerstroemia speciosa leaves in type ? diabetics: A dose-dependence study
    • Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R. Antidiabetic activity of a standardized extract (GlucosolTM) from Lagerstroemia speciosa leaves in type ? diabetics: a dose-dependence study. J Ethnopharmacol 2003; 87:115-117.
    • (2003) J Ethnopharmacol , vol.87 , pp. 115-117
    • Judy, W.V.1    Hari, S.P.2    Stogsdill, W.W.3    Judy, J.S.4    Naguib, Y.M.5    Passwater, R.6
  • 57
    • 0023872236 scopus 로고
    • Glucose-lowering effect of fenugreek in non-insulin dependent diabetics
    • Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr 1988;42:51- 54.
    • (1988) Eur J Clin Nutr , vol.42 , pp. 51-54
    • Madar, Z.1    Abel, R.2    Samish, S.3    Arad, J.4
  • 58
    • 0034598962 scopus 로고    scopus 로고
    • 4-hydroxyisoleucine: Effects of synthetic and natural analogues on insulin secretion
    • Broca C, Manteghetti M, Gross R, Baissac Y, Jacob M, Petit P, et al. 4-hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol 2000;390:339-345.
    • (2000) Eur J Pharmacol , vol.390 , pp. 339-345
    • Broca, C.1    Manteghetti, M.2    Gross, R.3    Baissac, Y.4    Jacob, M.5    Petit, P.6
  • 59
    • 0347987009 scopus 로고    scopus 로고
    • Supplementation of fenugreek leaves to diabetic rats: Effect on carbohydrate metabolic enzymes in diabetic liver and kidney
    • Devi BA, Kamalakkannan N, Prince PS. Supplementation of fenugreek leaves to diabetic rats: effect on carbohydrate metabolic enzymes in diabetic liver and kidney. Phytother Res 2003;17:1231-1233.
    • (2003) Phytother Res , vol.17 , pp. 1231-1233
    • Devi, B.A.1    Kamalakkannan, N.2    Prince, P.S.3
  • 60
    • 33748306020 scopus 로고    scopus 로고
    • Long-term effect of trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues
    • Preet A, Siddiqui MR, Taha A, Badhai J, Hussain ME, Yadava PK, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 2006;289:137-147.
    • (2006) Mol Cell Biochem , vol.289 , pp. 137-147
    • Preet, A.1    Siddiqui, M.R.2    Taha, A.3    Badhai, J.4    Hussain, M.E.5    Yadava, P.K.6
  • 61
    • 33646161004 scopus 로고    scopus 로고
    • Low doses of vanadate and trigonella synergistically regulate Na+/K+-ATPase activity and GLUT4 translocation in alloxandiabetic rats
    • Siddiqui MR, Moorthy K, Taha A, Hussain ME, Baquer NZ. Low doses of vanadate and trigonella synergistically regulate Na+/K+-ATPase activity and GLUT4 translocation in alloxandiabetic rats. Mol Cell Biochem 2006;285:17-27.
    • (2006) Mol Cell Biochem , vol.285 , pp. 17-27
    • Siddiqui, M.R.1    Moorthy, K.2    Taha, A.3    Hussain, M.E.4    Baquer, N.Z.5
  • 62
    • 31044456678 scopus 로고    scopus 로고
    • Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: A pilot study
    • Kochhar A, Nagi M. Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study. J Med Food 2005;8:545-549.
    • (2005) J Med Food , vol.8 , pp. 545-549
    • Kochhar, A.1    Nagi, M.2
  • 63
    • 27144500652 scopus 로고    scopus 로고
    • Supplementation of fenugreek leaves reduces oxidative stress in streptozotocininduced diabetic rats
    • Annida B, Stanely Mainzen, Prince P. Supplementation of fenugreek leaves reduces oxidative stress in streptozotocininduced diabetic rats. J Med Food 2005;8:382-385.
    • (2005) J Med Food , vol.8 , pp. 382-385
    • Annida, B.1    Stanely, M.2    Prince, P.3
  • 65
    • 0025015685 scopus 로고
    • Radha shanmugasundaram k, kizar ahmath b. use of gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus
    • Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-294.
    • (1990) J Ethnopharmacol , vol.30 , pp. 281-294
    • Shanmugasundaram, E.R.1    Rajeswari, G.2    Baskaran, K.3    Rajesh, K.B.R.4
  • 66
    • 0025087317 scopus 로고
    • Antidiabetic effect of a leaf extract from gymnema sylvestre in non-insulin-dependent diabetes mellitus patients
    • Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
    • (1990) J Ethnopharmacol , vol.30 , pp. 295-300
    • Baskaran, K.1    Kizar, A.B.2    Radha, S.K.3    Shanmugasundaram, E.R.4
  • 68
    • 70349140462 scopus 로고    scopus 로고
    • Effectiveness of cinnamon for lowering hemoglobin A1c in patients with type 2 diabetes: A randomized, controlled trial
    • Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1c in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-512.
    • (2009) J Am Board Fam Med , vol.22 , pp. 507-512
    • Crawford, P.1
  • 69
  • 70
    • 38749121378 scopus 로고    scopus 로고
    • Chromium and polyphenols from cinnamon improve insulin sensitivity
    • Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc 2008;67:48-53.
    • (2008) Proc Nutr Soc , vol.67 , pp. 48-53
    • Anderson, R.A.1
  • 71
    • 0034885329 scopus 로고    scopus 로고
    • A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes
    • Jarvill -Taylor KJ, Anderson RA, Graves DJ . A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-336.
    • (2001) J Am Coll Nutr , vol.20 , pp. 327-336
    • Jarvill -Taylor, K.J.1    Anderson, R.A.2    Graves, D.J.3
  • 73
    • 33847288191 scopus 로고    scopus 로고
    • The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial
    • Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2007;13:97-102.
    • (2007) J Altern Complement Med , vol.13 , pp. 97-102
    • Hsu, C.H.1    Liao, Y.L.2    Lin, S.C.3    Hwang, K.C.4    Chou, P.5
  • 74
    • 0036892408 scopus 로고    scopus 로고
    • Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism
    • Grover JK, Vats V, Yadav S. Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism. Mol Cell Biochem 2002;241:53-59.
    • (2002) Mol Cell Biochem , vol.241 , pp. 53-59
    • Grover, J.K.1    Vats, V.2    Yadav, S.3
  • 75
    • 57149123016 scopus 로고    scopus 로고
    • Resveratrol enhances glut-4 translocation to the caveolar lipid raft fractions through ampk/akt/enos signaling pathway in diabetic myocardium
    • Penumathsa SV, Thirunavukkarasu M, Zhan L, Maulik G, Menon VP, Bagchi D, et al. Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/AKT/eNOS signaling pathway in diabetic myocardium. J Cell Mol Med 2008;12:2350-2361.
    • (2008) J Cell Mol Med , vol.12 , pp. 2350-2361
    • Penumathsa, S.V.1    Thirunavukkarasu, M.2    Zhan, L.3    Maulik, G.4    Menon, V.P.5    Bagchi, D.6
  • 77
    • 0032888513 scopus 로고    scopus 로고
    • A comparative evaluation of some blood sugar lowering agents of plant origin
    • Chattopadhyay RR. A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol 1999;67:367-372.
    • (1999) J Ethnopharmacol , vol.67 , pp. 367-372
    • Chattopadhyay, R.R.1
  • 79
    • 0022629698 scopus 로고
    • Insulin- like molecules in Momordica charantia seeds
    • Ng TB, Wong CM, Li WW, Yeung HW. Insulin- like molecules in Momordica charantia seeds. J Ethnopharmacol 1986;15:107-117.
    • (1986) J Ethnopharmacol , vol.15 , pp. 107-117
    • Ng, T.B.1    Wong, C.M.2    Li, W.W.3    Yeung, H.W.4
  • 80
    • 1242329231 scopus 로고    scopus 로고
    • Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats
    • Yu BC, Hung CR, Chen WC, Cheng JT. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med 2003;69:1075-1079.
    • (2003) Planta Med , vol.69 , pp. 1075-1079
    • Yu, B.C.1    Hung, C.R.2    Chen, W.C.3    Cheng, J.T.4
  • 81
    • 0033659186 scopus 로고    scopus 로고
    • Antihyperglycemic effects of gymnemic acid ?, A compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice
    • Sugihara Y, Nojima H, Matsuda H, Murakami T, Yoshikawa M, Kimura I. Antihyperglycemic effects of gymnemic acid ?, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res 2000;2:321-327.
    • (2000) J Asian Nat Prod Res , vol.2 , pp. 321-327
    • Sugihara, Y.1    Nojima, H.2    Matsuda, H.3    Murakami, T.4    Yoshikawa, M.5    Kimura, I.6
  • 82
    • 16444381623 scopus 로고    scopus 로고
    • Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice
    • Ohnishi M, Matuo T, Tsuno T, Hosoda A, Nomura E, Taniguchi H, et al. Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice. Bio Factors 2004;21:315-319.
    • (2004) Bio Factors , vol.21 , pp. 315-319
    • Ohnishi, M.1    Matuo, T.2    Tsuno, T.3    Hosoda, A.4    Nomura, E.5    Taniguchi, H.6
  • 83
  • 84
    • 0022384509 scopus 로고
    • Effects of fl avonoids on insulin secretion and 45Ca2+ handling in rat islets of langerhans
    • Hii CS, Howell SL. Effects of fl avonoids on insulin secretion and 45Ca2+ handling in rat islets of langerhans. J Endocrinol 1985;107:1-8.
    • (1985) J Endocrinol , vol.107 , pp. 1-8
    • Hii, C.S.1    Howell, S.L.2
  • 85
    • 0037657668 scopus 로고    scopus 로고
    • Soyisofl avones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
    • Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soyisofl avones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 2003;133:1238-1243.
    • (2003) J Nutr , vol.133 , pp. 1238-1243
    • Mezei, O.1    Banz, W.J.2    Steger, R.W.3    Peluso, M.R.4    Winters, T.A.5    Shay, N.6
  • 86
    • 0037144406 scopus 로고    scopus 로고
    • Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production
    • Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 2002;277:34933-34940.
    • (2002) J Biol Chem , vol.277 , pp. 34933-34940
    • Waltner-Law, M.E.1    Wang, X.L.2    Law, B.K.3    Hall, R.K.4    Nawano, M.5    Granner, D.K.6
  • 87
    • 0019811773 scopus 로고
    • The prophylactic action of (-)-epicatechin against alloxan induced diabetes in rats
    • Chakravarthy BK, Gupta S, Gambhir SS, Gode KD. The prophylactic action of (-)-epicatechin against alloxan induced diabetes in rats. Life Sci 1981;29:2043-2047.
    • (1981) Life Sci , vol.29 , pp. 2043-2047
    • Chakravarthy, B.K.1    Gupta, S.2    Gambhir, S.S.3    Gode, K.D.4
  • 88
    • 0035725639 scopus 로고    scopus 로고
    • Insulin-like effect of (-)epicatechin on erythrocyte membrane acetylcholinesterase activity in type 2 diabetes mellitus
    • Rizvi SI, Zaid MA. Insulin-like effect of (-)epicatechin on erythrocyte membrane acetylcholinesterase activity in type 2 diabetes mellitus. Clin Exp Pharmacol Physiol 2001;28:776-778.
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 776-778
    • Rizvi, S.I.1    Zaid, M.A.2
  • 89
    • 0027393075 scopus 로고
    • Antidiabetic effects of a glycoside of leucopelargonidin isolated from Ficus bengalensis Linn
    • Cherian S, Augusti KT. Antidiabetic effects of a glycoside of leucopelargonidin isolated from Ficus bengalensis Linn. Indian J Exp Biol 1993;31:26-29.
    • (1993) Indian J Exp Biol , vol.31 , pp. 26-29
    • Cherian, S.1    Augusti, K.T.2
  • 90
    • 0345599950 scopus 로고    scopus 로고
    • Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of langerhans
    • Cooper EJ, Hudson AL, Parker CA, Morgan NG. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of langerhans. Eur J Pharmacol 2003;482:189-196.
    • (2003) Eur J Pharmacol , vol.482 , pp. 189-196
    • Cooper, E.J.1    Hudson, A.L.2    Parker, C.A.3    Morgan, N.G.4
  • 91
    • 0026773906 scopus 로고
    • Antidiabetic effects of S-Allyl cysteine sulphoxide isolated from garlic Allium sativum Linn
    • Sheela CG, Augusti KT. Antidiabetic effects of S-Allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J Exp Biol 1992;30:523-526.
    • (1992) Indian J Exp Biol , vol.30 , pp. 523-526
    • Sheela, C.G.1    Augusti, K.T.2
  • 92
    • 0029081239 scopus 로고
    • Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats
    • Sheela CG, Kumud K, Augusti KT. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995;61:356-357.
    • (1995) Planta Med , vol.61 , pp. 356-357
    • Sheela, C.G.1    Kumud, K.2    Augusti, K.T.3
  • 93
    • 0016780792 scopus 로고
    • Hypoglycaemic effects of onion, Allium cepa Linn. On diabetes mellitus: A preliminary report
    • Mathew PT, Augusti KT. Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus: a preliminary report. Indian J Physiol Pharmacol 1975;19:213-217.
    • (1975) Indian J Physiol Pharmacol , vol.19 , pp. 213-217
    • Mathew, P.T.1    Augusti, K.T.2
  • 94
    • 0029247886 scopus 로고
    • Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from allium cepa linn
    • Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys 1995;32:49-54.
    • (1995) Indian J Biochem Biophys , vol.32 , pp. 49-54
    • Kumari, K.1    Mathew, B.C.2    Augusti, K.T.3
  • 95
    • 70350605742 scopus 로고    scopus 로고
    • Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes
    • Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 2009;16:1119-1126.
    • (2009) Phytomedicine , vol.16 , pp. 1119-1126
    • Prabhakar, P.K.1    Doble, M.2
  • 96
    • 79951719120 scopus 로고    scopus 로고
    • Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes
    • Prabhakar PK, Doble M. Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes. Phytomedicine 2010;18:285-291.
    • (2010) Phytomedicine , vol.18 , pp. 285-291
    • Prabhakar, P.K.1    Doble, M.2


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