Antihyperglycemic Effect of Andrographolide in Streptozotocin-Induced Diabetic Rats

Planta Medica

Volumn 69, Issue 12, 2003, Pages 1075-1079

  Yu, Bu Chin ^a   Hung, Chen Road ^a   Chen, Wang Chuan ^b   Cheng, Juei Tang ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b Department of Chinese Medicine   (Taiwan)

Author keywords

Acanthaceae; Andrographis paniculata; Andrographolide; Insulin independent diabetes mellitus; STZ diabetic rats

Indexed keywords

ANDROGRAPHOLIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; MESSENGER RNA; PROTEIN; RADIOACTIVE MATERIAL; STREPTOZOCIN;

ANDROGRAPHIS PANICULATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INTRAVENOUS GLUCOSE TOLERANCE TEST; ISOLATION PROCEDURE; MALE; NONHUMAN; PLANT LEAF; RAT; SOLEUS MUSCLE;

ADMINISTRATION, ORAL; ANDROGRAPHIS; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHYTOTHERAPY; PLANT LEAVES; RATS; RATS, WISTAR; RNA, MESSENGER; STREPTOZOCIN;

ACANTHACEAE; ANDROGRAPHIS PANICULATA; ANIMALIA;

EID: 1242329231     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-45185     Document Type: Article

References (19)

1. Weidmann P, de Courten M, Boehlen LM. Pathogenesis and treatment of hypertension associated with diabetes mellitus. Am Heart J 1993; 125: 1498-513
2. Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Indian J Exp Biol 2001; 39: 41-6
3. Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 2000; 7: 351-64
4. Zhang XF, Tan BK. Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clin Exp Pharmacol Physiol 2000; 27: 358-63
5. Lu XL, Zhang SL, Wang ZS. Analysis of andrographolide compounds. 1. Ion pair high performance liquid chromatographic analysis of andrographolide derivatives. Yao Xue Xue Bao 1981; 16: 182-9
6. Maiti PC. Andrographolide: The active principle of Kalmegh. Bull Bot Surv India 1964; 6: 63-5
7. Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol 2002; 135: 399-406
8. Ahmed M, Talukder SA. Studies on the hypoglycemic activity of Kalmegh (Andrographis paniculata Nees.) on the blood sugar level of rats. Bangladesh Pharm J 1977; 6: 21-4
9. Cheng JT, Liu IM, Chi TC, Su HC, Chang CG. Metformin-like effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat. Horm Metab Res 2001; 33: 727-32
10. Liu IM, Chi TC, Hsu FL, Chen CF, Cheng JT. Isoferulic acid as active principle from the rhizoma of Cimicifuga dahurica to lower plasma glucose in diabetic rats. Planta Med 1999; 65: 712-4
11. Liu IM, Hsu FL, Chen CF, Cheng JT. Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. Br J Pharmacol 2000; 129: 631-6
12. Cheng JT, Liu IM, Chi TC, Tzeng TF, Lu FH, Chang CJ. Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats. Diabetes 2001; 50: 2815-21
13. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988; 255: E769-74
14. Ziel FH, Venkatesan N, Davidson MB. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 1988; 37: 885-90
15. Hollenbeck C, Reaven GM. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 1987; 64: 1169-73
16. Pessin JE, Bell GI. Mammalian facilitative glucose transporter family: structure and molecular regulation. Annu Rev Physiol 1992; 54: 911-30
17. Berger J, Biswas C, Vicario PP, Strout HV, Saperstein R, Pilch PF. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature 1989; 340: 70-2
18. Sivitz WI, Desautel SL, Kayano T, Bell GI, Pessin JE. Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature 1989; 340: 72-4
19. Henriksen EJ, Bourey RE, Rodnick KJ, Koranyl L, Permutt MA, Holloszy JO. Glucose transporter protein content and glucose transport capacity in rat skeletal muscles. Am J Physiol 1990; 259: E593-8