A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials

Phytotherapy Research

Volumn 22, Issue 7, 2008, Pages 851-858

  Xiang, Yao Zu ^a   Shang, Hong Cai ^a   Gao, Xiu Mei ^a   Zhang, Bo Li ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Clinical trials; Modern pharmacological experiments; Panax ginseng; TCM

Indexed keywords

ALCOHOL DERIVATIVE; GINSENG EXTRACT; GINSENOSIDE; HERBACEOUS AGENT; OLEANOLIC ACID; PANAXADIOL; PANAXATRIOL; PEPTIDE; POLYSACCHARIDE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANEMARRHENAE; ANOREXIA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ASIA; ATRACTYLODES MACROCEPHALA; BLEEDING; CARDIOVASCULAR RISK; CENTRAL NERVOUS SYSTEM; CHINA; CHINESE MEDICINE; CLINICAL TRIAL; COGNITION; CYPSUM FIBROSUM; DIABETES MELLITUS; DRUG EFFICACY; DYSPNEA; GINSENG; GLYCYRRHIZA; HEART PALPITATION; HUMAN; HYPODYNAMIA; IMMUNOMODULATION; IMMUNOSTIMULATION; IMPOTENCE; INSOMNIA; KOREA; MEDICINAL PLANT; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PHYSICAL PERFORMANCE; PLANT ROOT; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; REHMANNIA; REVIEW; SALVIA MILTIORRHIZA; SNAKEGOURD; TUCKAHOE;

DRUGS, CHINESE HERBAL; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HISTORY, ANCIENT; MEDICINE, CHINESE TRADITIONAL; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

PANAX GINSENG;

EID: 48749094892     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2384     Document Type: Review

References (86)

1. Attele AS, Wu JA, Yuan CS. 1999. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58: 1685-1693.
2. Back Nl, Kim DS, Lee YH, Park JD, Lee CB, Kim SI. 1996. Ginsenoside Rh4, a genuine dammarane glycoside from korean red ginseng. Planta Med 62: 86-87.
3. Bae EA, Kim EJ, Park JS, Kim HS, Ryu JH, Kim DH. 2006. Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells. Planta Med 72: 627-633.
4. Bahrke MS, Morgan WR. 2000. Evaluation of the ergogenic properties of ginseng: an update. Sports Med 29: 113-133.
5. Bai CX, Sunami A, Namiki T, Sawanobori T, Furukawa T. 2003. Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes. Eur J Pharmacol 476: 35-44.
6. Blumenthal M. 2001. Herb sales down 15 percent in mainstream market. Herbalgram 51: 69.
7. Buettner C, Yeh GY, Phillips RS, Mittleman MA, Kaptchuk TJ. 2006. Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother 40: 83-95.
8. Byun BH, Shin I, Yoon YS, Kim SI, Joe CO. 1997. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. Planta Med 63: 389-392.
9. Chan LY, Chiu PY, Lau TK. 2004. Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture. Reprod Toxicol 19: 131-134.
10. Chen XC, Chen Y, Zhu YG, Fang F, Chen LM. 2002. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 23: 829-834.
11. Chen XC, Chen LM, Zhu YG, Fang F, Zhou YC, Zhao CH. 2003a. Involvement of CDK4, pRB, and E2F1 in ginsenoside Rgl protecting rat cortical neurons from beta-amyloid-induced apoptosis. Acta Pharmacol Sin 24: 1259-1264.
12. Chen XC, Fang F, Zhu YG, Chen LM, Zhou YC, Chen Y. 2003b. Protective effect of ginsenoside Rg1 on MPP - induced apoptosis in SHSY5Y cells. J Neural Transm 110: 835-845.
13. Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM. 2005. Ginsenoside Rg1 reduces MPTP - induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol Sin 26: 56-62.
14. Chen XC, Zhu YG, Zhu LA et al. 2003c. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol 473: 1-7.
15. Cho J, Park W, Lee S, Ahn W, Lee Y. 2004. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 89: 3510-3515.
16. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. 2006. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 550: 173-179.
17. Choi S. 2002. Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. Arch Pharm Res 25: 71-76.
18. Coleman CI, Hebert JH, Reddy P. 2003. The effects of Panax ginseng on quality of life. J Clin Pharm Ther 28: 5-15.
19. Coon JT, Ernst E. 2002. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf 25: 323-344.
20. Fleming T. 1998. Physician Desk References for Herbal Medicine. Medical Economics Company: New Jersey, 1101
21. Furukawa T, Bai CX, Kaihara A et al. 2006. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 70: 1916-1924.
22. Goldstein B. 1975. Ginseng: its history, dispersion, and folk tradition. Am J Chin Med 3: 223-234.
23. Hu SY. 1977. A contribution to our knowledge of ginseng. Am J Chin Med 5: 1-23
24. Huang YC, Chen CT, Chen SC et al. 2005. A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm Res 22: 636-646.
25. Jeong CS, Hyun JE, Kim YS. 2003. Ginsenoside Rb1: the antiulcer constituent from the head of Panax ginseng. Arch Pharm Res 26: 906-911.
26. Jeong SM, Lee JH, Kim JH et al. 2004. Stereospecificity of ginsenoside Rg3 action on ion channels. Mol Cells 18: 383-389.
27. Ji ZN, Dong TT, Ye WC, Choi RC, Lo CK, Tsim KW. 2006. Ginsenoside Re attenuate beta-amyloid and serum-free induced neurotoxicity in PC12 cells. J Ethnopharmacol 107: 48-52.
28. Joo SS, Lee Dl. 2005. Potential effects of microglial activation induced by ginsenoside Rg3 in rat primary culture: enhancement of type A macrophage scavenger receptor expression. Arch Pharm Res 28: 1164-1169.
29. Kang YJ, Sohn JT, Chang KC. 2005. Relaxation of canine corporal smooth muscle relaxation by ginsenoside saponin Rg3 is independent from eNOS activation. Life Sci 77: 74-84.
30. Keum YS, Han SS, Chun KS et al. 2003. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res 523-524: 75-85.
31. Kim HS, Hwang SL, Oh S. 2000. Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats. Neurochem Res 25: 1149-1154.
32. Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, Im DS. 2004. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27: 429-435.
33. Kim JH, Hong YH, Lee JH et al. 2005. A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition. Mol Cells 19: 137-142.
34. Kim ND, Kim EM, Kang KW, Cho MK, Choi SY, Kim SG. 2003. Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 140: 661-670.
35. Lee HU, Bae EA, Han MJ, Kim DH. 2005a. Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. Biol Pharm Bull 28: 1992-1994.
36. Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. 2005b. Hepatoprotective effect of ginsenoside Rbl and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 25: 1069-1073.
37. Lee H, Gonzalez FJ, Yoon M. 2006. Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun 339: 196-203.
38. Lee BH, Jeong SM, Ha TS et al. 2004a. Ginsenosides regulate ligand-gated ion channels from the outside. Mol Cells 18: 115-121.
39. Lee EJ, Ko E, Lee J et al. 2004b. Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation. Int Immunopharmacol 4: 235-244.
40. + current inhibition. Mol Pharmacol 68: 1114-1126.
41. Lee SH, Jung BH, Choi SY, Kim SY, Lee EH, Chung BC. 2006. Influence of ginsenoside Rb1 on brain neurosteroid during acute immobilization stress. Arch Pharm Res 29: 566-569.
42. Lee YJ, Jin YR, Lim WC et al. 2003. Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. Arch Pharm Res 26: 53-57.
43. Lei ZQ, Chen SY, Gao XM. 1995. Chinese Materia Medica. Shanghai Science and Technology Press: Shanghai.
44. Leung KW, Cheng YK, Mak NK, Chan KK, Fan TP, Wong RN. 2006a. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett 580: 3211-3216.
45. Leung KW, Pon YL, Wong RN, Wong AS. 2006b. Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylino-sitol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells. J Biol Chem 281: 36280-36288.
46. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN. 2007. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 52: 827-835.
47. Li JQ, Zhang JT. 1997. Effects of age and ginsenoside RG1 on membrane fluidity of cortical cells in rats. Acta Pharm Sin 32: 23-27.
48. Liberti LE, Der Marderosian A. 1978. Evaluation of commercial ginseng products. J Pharm Sci 10: 1487-1489.
49. Lim JH, Wen TC, Matsuda S et al. 1997. Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root. Neurosci Res 28: 191-200.
50. Liu C-X, Xiao P-G. 1992. Recent advances in ginseng research in China. J Ethnopharmacol 36: 27-38.
51. Liu JW, Wei DZ, Du CB, Zhong JJ. 2003. Enhancement of fibrinolytic activity of bovine aortic endothelial cells by ginsenoside Rb2. Acta Pharmacol Sin 24: 102-108.
52. Liu M, Zhang JT. 1995. The immunoregulatory effects of ginsenoside Rg1 in aged rats. Acta Pharm Sin 30: 818-823.
53. Liu M, Zhang JT.1996. Studies on the mechanisms of immunoregulatory effects of ginsenoside Rg1 in aged rats. Acta Pharm Sin 31: 95-100.
54. Mannaa F, Abdel-Wahhab MA, Ahmed HH, Park MH. 2006. Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. J Appl Toxicol 26: 198-206.
55. Min JK, Kim JH, Cho YL et al. 2006. 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem Biophys Res Commun 349: 987-994.
56. Murphy LL, Lee TJ. 2002. Ginseng, sex behavior and nitric oxide. Ann NY Acad Sci 962: 372-377.
57. Park KH, Shin HJ, Song YB et al. 2002. Possible role of ginsenoside Rb1 on regulation of rat liver triglycerides. Biol Pharm Bull 25: 457-460.
58. Phillipson JD, Anderson LA. 1984. Ginseng-quality safety and efficacy? Pharm J 232: 161-165.
59. Rhim H, Kim H, Lee DY, Oh TH, Nah SY. 2002. Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. Eur J Pharmacol 436: 151-158.
60. Rivera E, Ekholm Pettersson F, Inganas M, Paulie S, Gronvik KO. 2005. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 23: 5411-5419.
61. Sala F, Mulet J, Choi S et al. 2002. Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. J Pharmacol Exp Ther 301. 1052-1059.
62. Salim KN, McEwen BS, Chao HM. 1997. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. Brain Res Mol Brain Res 47: 177-182.
63. Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, Azuma I. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull 17: 635-639.
64. Shen LH, Zhang JT. 2004. Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells. Neurol Res 26: 422-428.
65. Shin YW, Bae EA, Kim SS, Lee YC, Kim DH. 2005. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. Int Immunopharmacol 5: 1183-1191.
66. Shin YW, Kim DH. 2005. Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models. J Pharmacol Sci 99: 83-88.
67. Stancheva SL, Alova LG. 1993. Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats. Gen Pharmacol 24: 1459-1462
68. Tachikawa E, Kudo K, Harada K et al. 1999.Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol 369: 23-32.
69. Tian J, Fu F, Geng M et al. 2005. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 374: 92-97.
70. Tsai SC, Chiao YC, Lu CC, Wang PS. 2003. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol 46: 1-7.
71. Tyler VE. 1993. The Honest Herbal - A Sensible Guide To The Use of Herbs and Related Remedies. Haworth Press: New York, 149
72. Ushio Y. 1992. Effect of ginsenoside Rgl on the release of enzymes by cultured endothelial cells. Am J Chin Med 20: 91-101.
73. Vogler BK, Pittler MH, Ernst E. 1999. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 55: 567-575.
74. Wakabayashi C, Hasegawa H, Murata J, Saiki I. 1997. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolism after oral administration. Oncol Res 9: 411-417.
75. Wang XY, Zhang JT. 2001a. Effects of ginsenoside Rg1 on synaptic plasticity of freely moving rats and its mechanism of action. Acta Pharmacol Sin 22: 657-662.
76. Wang XY, Zhang JT. 2001b. Effects of ginenoside Rg1 on learning and memory impairment induced by β-amyloid peptide (25-35) and its mechanism of action. Acta Pharm Sin 36: 1-4.
77. Wen TC, Yoshimura H, Matsuda S, Lim JH, Sakanaka M. 1996. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischaemia. Acta Neuropathol 91: 15-22.
78. Xie JT, Mehendale SR, Li X et al. 2005. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta 1740: 319-325.
79. Xu BB, Liu CQ, Gao X, Zhang WQ, Wang SW, Cao YL. 2005a. Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model. J Asian Nat Prod Res 7: 215-224.
80. Xu YX, Shi JS, Jiang ZL. 2005b. Inhibitory influence of ginsenoside Rb(3) on activation of strychnine-sensitive glycine receptors in hippocampal neurons of rat. Brain Res 1037: 99-106.
81. Xue JF, Liu ZJ, Hu JF, Chen H, Zhang JT, Chen NH. 2006. Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. Brain Res 1106: 91-98.
82. Yokozawa T, Satoh A, Cho EJ. 2004. Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice. J Pharm Pharmacol 56: 107-111
83. Yue PY, Wong DY, Wu PK et al. 2006. The angiosuppressive effects of 20(R)-ginsenoside Rg3. Biochem Pharmacol 72: 437-445.
84. Zeng YQ, Chen XC, Zhu YG et al. 2005. Ginsenoside Rbl attenuates beta-amyloid peptide 25-35-induced tau hyper-phosphorylation in cortical neurons. Yao Xue Xue Bao 40: 225-230.
85. Zhang H, Zhou QM, Li XD et al. 2006. Ginsenoside R(e) increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase. Arch Pharm Res 29: 145-151.
86. Zhang H, Zhou Q, Li X et al. 2007. Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway. Mol Reprod Dev 74: 497-501.