TGF-β signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: Role of the β-spectrin, ELF

Biochemical and Biophysical Research Communications

Volumn 344, Issue 4, 2006, Pages 1216-1223

  Kim, Sang Soo ^a   Shetty, Kirti ^a   Katuri, Varalakshmi ^a   Kitisin, Krit ^a   Baek, Hye Jung ^a   Tang, Yi ^a   Marshall, Blair ^a   Johnson, Lynt ^a   Mishra, Bibhuti ^a   Mishra, Lopa ^a,b  

^a GEORGETOWN UNIVERSITY   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Cell cycle; ELF; Gastric cancer; Senescence; Smad4

Indexed keywords

CYCLIN DEPENDENT KINASE 4; K RAS PROTEIN; PROTEIN P21; SMAD4 PROTEIN; SPECTRIN; SPECTRIN BETA SUBUNIT; TRANSCRIPTION FACTOR ELF 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DISRUPTION; CELL LOSS; CONTROLLED STUDY; MALIGNANT TRANSFORMATION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE; SIGNAL TRANSDUCTION; SPECIES COMPARISON; STOMACH CANCER; STOMACH CARCINOGENESIS; TRANSCRIPTION TERMINATION;

AGING; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE 4; MICE; MICE, MUTANT STRAINS; SIGNAL TRANSDUCTION; SPECTRIN; STOMACH NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 33646470279     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.03.236     Document Type: Article

References (49)

1. Guilford P., Hopkins J., Harraway J., McLeod M., McLeod N., Harawira P., Taite H., Scoular R., Miller A., and Reeve A.E. E-cadherin germline mutations in familial gastric cancer. Nature 392 (1998) 402-405
2. Goodman K.J., and Cockburn M. The role of epidemiology in understanding the health effects of Helicobacter pylori. Epidemiology 12 (2001) 266-271
3. Setiawan V.W., Zhang Z.F., Yu G.P., Lu Q.Y., Li Y.L., Lu M.L., Wang M.R., Guo C.H., Yu S.Z., Kurtz R.C., and Hsieh C.C. GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population. Cancer Causes Control 12 (2001) 673-681
4. Rhyu M.G., Park W.S., and Meltzer S.J. Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9 (1994) 29-32
5. Hatakeyama M. Oncogenic mechanisms of the Helicobacter pylori CAGA protein. Nat. Rev. Cancer 4 (2004) 688-694
6. Wu M.S., Lee C.W., Shun C.T., Wang H.P., Lee W.J., Chang M.C., Sheu J.C., and Lin J.T. Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes. Genes Chromosomes Cancer 27 (2000) 403-411
7. Kim Y.H., Lee H.S., Lee H.J., Hur K., Kim W.H., Bang Y.J., Kim S.J., Lee K.U., Choe K.J., and Yang H.K. Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas. Ann. Oncol. 15 (2004) 574-580
8. Attisano L., and Wrana J.L. Mads and Smads in TGF β signaling. Curr. Opin. Cell Biol. 10 (1998) 188-194
9. Heldin C.-H., Miyazono K., and ten Dijke P. TGF-β signaling from cell membrane to nucleus through Smad proteins. Nature 390 (1997) 465-467
10. Shi Y., and Massague J. Mechanisms of TGF-β signaling from cell membrane to nucleus. Cell 113 (2003) 685-700
11. Powell S.M., Harper J.C., Hamilton S.R., Robinson C.R., and Cummings O.W. Inactivation of Smad4 in gastric carcinomas. Cancer Res. 57 (1997) 4221-4224
12. Weinstein M., Yang X., and Deng C. Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev. 11 (2000) 49-58
13. Xu J., and Attisano L. Mutations in the tumor suppressors Smad2 and Smad4 inactivate TGF-β signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 97 (2000) 4820-4825
14. Miyazono K., Suzuki H., and Imamura T. Regulation of TGF-β signaling and its roles in progression of tumors. Cancer Sci. 94 (2003) 230-234
15. Ito K., Liu Q., Salto-Tellez M., Yano T., Tada K., Ida H., Huang C., Shah N., Inoue M., Rajnakova A., et al. Runx3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 65 (2005) 7743-7750
16. Tang Y., Katuri V., Dillner A., Mishra B., Deng C.X., and Mishra L. Disruption of TGF-β signaling in elf beta-spectrin deficient mice. Science 299 (2003) 574-577
17. Mishra L., Cia T., Yu P., Monger P., and Mishra B. elf3 encodes a novel 200 KD β-spectrin: role in liver development. Oncogene 18 (1999) 353-364
18. Katuri V., Tang Y., Cuiling L., Jogunoori W., Deng C.X., Rashid A., Sidawy A., Evans S., Mishra B., and Mishra L. Critical interactions between TGF signaling/elf and E-Cadherin beta-catenin mediated tumor suppression. Oncogene (2005) Epub ahead of print
19. Redman R.S., Katuri V., Tang Y., Dillner A., Mishra B., and Mishra L. Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice. J. Oral Pathol. Med. 34 (2005) 23-29
20. Massague J., Blain S.W., and Lo R.S. TGF-β signaling in growth control, cancer and heritable disorders. Cell 103 (2000) 295-309
21. Ko T.C., Sheng H.M., Reisman D., Thompson E.A., and Beauchamp R.D. Transforming growth factor beta 1 inhibits cyclin D1 expression in intestinal epithelial cells. Oncogene 10 (1995) 177-184
22. Slingerland J.M., Hengst L., Pan C., Alexander D., Stampfer M.R., and Reed S.I. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol. Cell. Biol. 14 (1994) 3683-3694
23. Geng Y., and Weinberg R.A. TGF-beta effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc. Natl. Acad. Sci. USA 90 (1993) 10315-10319
24. Ewen M.E., Sluss H.K., Whitehouse L.L., and Livingston D.M. TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 74 (1993) 1009-1020
25. Koff A., Ohtsuki M., Polyak K., Roberts J.M., and Massague J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 260 (1993) 536-539
26. Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., and Wang X.-F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92 (1995) 5545-5549
27. INK4B is a potential effector of TGF-β induced cell-cycle arrest. Nature 371 (1994) 257-261
28. Polyak K., Kato J.Y., Solomon M.J., Sherr C.J., Massague J., Roberts J.M., and Koff A. p27Kip1, a cyclin cdk inhibitor links TGF beta and contact inhibition to cell cycle arrest. Genes Dev. 8 (1994) 9-22
29. Gold L.I. The role for transforming growth factor beta in human cancer. Crit. Rev. Oncog. 10 (1999) 303-360
30. Laiho M., Decaprio J.A., Ludlow J.W., Livingston D.M., and Massague J. Growth inhibition by TGF-beta linked to suppression of retinoblastoma-protein phosphorylation. Cell 62 (1990) 175-185
31. Datto M.B., and Wang X.-F. Functional analysis of the TGF-β responsive elements in the WAF1/Cip1/p21 promoter. J. Biol. Chem. 270 (1995) 28623-28628
32. Gartenhaus R.B., Wang P., and Hoffmann P. Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type 1 transformed lymphocytes after treatment with adriamycin by using a p53 independent pathway. Proc. Natl. Acad. Sci. USA 93 (1996) 265-268
33. Reynisdottir I., Polyak K., Iavarone A., and Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell-cycle arrest in response to TGF-β. Genes Dev. 9 (1995) 1831-1845
34. INK4B through a Spl consensus site. J. Biol. Chem. 270 (1995) 26750-26753
35. Yoo Y.D., Choi J.-Y., Lee S.-J., Kim J.S., Min B.-R., Lee Y.I., and Kang Y.-K. TGF-β induced cell-cycle arrest through the p21 WAF/CIP1-G1 cyclin/CDKS-p130 pathway in gastric carcinoma cells. Int. J. Cancer 83 (1999) 512-517
36. Campisi J. Cancer, aging and cellular senescence. In Vivo 14 (2000) 183-188
37. Sherwood S.W., Rush D., Ellsworth J.L., and Schimke R.T. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl. Acad. Sci. USA 85 (1988) 9086-9090
38. Kulju K.S., and Lehman J.M. Increased p53 protein associated with aging in human diploid fibroblasts. Exp. Cell Res. 217 (1995) 336-345
39. Atadja P., Wong H., Garkavtsev J., Veillette C., and Riabowol K. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. USA 92 (1995) 8348-8352
40. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., and Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211 (1994) 90-98
41. Sherr C.J., and Roberts J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9 (1995) 1149-1163
42. Harper J.W., Adami G.R., Wei N., Keyomarsi K., and Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75 (1993) 805-816
43. Waga S., Hannon G.J., Beach D., and Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369 (1994) 574-578
44. Li R., Waga S., Hannon G.J., Beach D., and Stillman B. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371 (1994) 534-537
45. Merritt A.J., Potten C.S., Kemp C.J., Hickman J.A., Balmain A., Lane D.P., and Hall P.A. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53 deficient mice. Cancer Res. 54 (1994) 614-617
46. Levine A.J., Momand J., and Finlay C.A. The p53 tumour suppressor gene. Nature 351 (1991) 453-456
47. Brembeck F.H., Schreiber F.S., Deramaudt T.B., Craig L., Rhoades B., Swain G., Grippo P., Stoffers D.A., Silberg D.G., and Rustgi A.K. The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Res. 63 (2003) 2005-2009
48. Hongyo T., Buzard G.S., Palli D., Weghorst C.M., Amorosi A., Galli M., Caporaso N.E., Fraumeni Jr. J.F., and Rice J.M. Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy. Cancer Res. 55 (1995) 2665-2672
49. Yoo J., Park S.Y., Robinson R.A., Kang S.J., Ahn W.S., and Kang C.S. Ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas. Arch. Pathol. Lab. Med. 126 (2002) 1096-1100