Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation

Hepatology

Volumn 45, Issue 1, 2007, Pages 31-41

  Nguyen, Lananh N ^a   Furuya, Momoko H ^a   Wolfraim, Lawrence A ^b   Nguyen, Anthony P ^a   Holdren, Matthew S ^a   Campbell, Jean S ^a   Knight, Belinda ^c   Yeoh, George C T ^c   Fausto, Nelson ^a   Parks, W Tony ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; ETHIONINE; KI 67 ANTIGEN; PHOSPHO SMAD2 PROTEIN; SMAD2 PROTEIN; SMAD6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DRUG MECHANISM; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; STAINING;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEPATOCYTES; MICE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33846454667     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21466     Document Type: Article

References (29)

1. Carr BI, Huang TH, Itakura K, Noel M, Marceau N. TGF beta gene transcription in normal and neoplastic liver growth. J Cell Biochem 1989; 39:477-487.
2. Nakamura T, Tomita Y, Hirai R, Yamaoka K, Kaji K, Ichihara A. Inhibitory effect of transforming growth factor-beta on DNA synthesis of adult rat hepatocytes in primary culture. Biochem Biophys Res Commun 1985; 133:1042-1050.
3. Braun L, Mead JE, Panzica M, Mikumo R, Bell GI, Fausto N. Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci U S A 1988;85:1539-1543.
4. Carr BI, Hayashi I, Branum EL, Moses HL. Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor. Cancer Res 1986;46:2330-2334.
5. Oberhammer F, Bursch W, Parzefall W, Breit P, Erber E, Stadler M, et al. Effect of transforming growth factor beta on cell death of cultured rat hepatocytes. Cancer Res 1991;51:2478-2485.
6. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, et al. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci U S A 1992;89:5408-5412.
7. Malik R, Selden C, Hodgson H. The role of non-parenchymal cells in liver growth. Semin Cell Dev Biol 2002;13:425-431.
8. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004;5:836-847.
9. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-218.
10. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
11. ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004;29:265-273.
12. Paku S, Schnur J, Nagy P, Thorgeirsson SS. Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol 2001;158: 1313-1323.
13. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, et al. The canals of Hering and hepatic stem cells in humans. HEPATOLOGY 1999;30:1425-1433.
14. Fausto N, Campbell JS. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech Dev 2003;120:117-130.
15. Roskams TA, Libbrecht L, Desmet VJ. Progenitor cells in diseased human liver. Semin Liver Dis 2003;23:385-396.
16. Lowes KN, Croager EJ, Olynyk JK, Abraham LJ, Yeoh GC. Oval cell-mediated liver regeneration: role of cytokines and growth factors. J Gastroenterol Hepatol 2003;18:4-12.
17. Knight B, Yeoh GC, Husk KL, Ly T, Abraham LJ, Yu C, et al. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 2000;192:1809-1818.
18. Akhurst B, Matthews V, Husk K, Smyth MJ, Abraham LJ, Yeoh GC. Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury. HEPATOLOGY 2005;41:327-335.
19. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest 2005;115:2330-2340.
20. Bisgaard HC, Muller S, Nagy P, Rasmussen LJ, Thorgeirsson SS. Modulation of the gene network connected to interferon-gamma in liver regeneration from oval cells. Am J Pathol 1999;155:1075-1085.
21. Brooling JT, Campbell JS, Mitchell C, Yeoh GC, Fausto N. Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gamma. HEPATOLOGY 2005;41:906-915.
22. Lazaro CA, Rhim JA, Yamada Y, Fausto N. Generation of hepatocytes from oval cell precursors in culture. Cancer Res 1998;58:5514-5522.
23. Pierce RH, Campbell JS, Stephenson AB, Franklin CC, Chaisson M, Foot M, et al. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. Am J Pathol 2000;157:221-236.
24. Wu JC, Merlino G, Cveklova K, Mosinger B Jr, Fausto N. Autonomous growth in serum-free medium and production of hepatocellular carcinomas by differentiated hepatocyte lines that overexpress transforming growth factor alpha 1. Cancer Res 1994;54:5964-5973.
25. Kitamura K, Aota S, Sakamoto R, Yoshikawa SI, Okazaki K. Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation. Blood 2000;95:3371-3379.
26. Braun L, Goyette M, Yaswen P, Thompson NL, Fausto N. Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats. Cancer Res 1987;47:4116-4124.
27. Fafeur V, O'Hara B, Bohlen P. A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways. Mol Biol Cell 1993;4:135-144.
28. Greenwald J, Le V, Corrigan A, Fischer W, Komives E, Vale W, et al. Characterization of the extracellular ligand-binding domain of the type II activin receptor. Biochemistry 1998;37:16711-16718.
29. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 1997;389: 622-626.