Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model

Anesthesiology

Volumn 116, Issue 1, 2012, Pages 122-132

  Ren, Bing Xu ^a   Gu, Xiao Ping ^a   Zheng, Ya Guo ^a   Liu, Cheng Long ^a   Wang, Dan ^a   Sun, Yu E ^a   Ma, Zheng Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 CHLORO 5 HYDROXYPHENYLGLYCINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; ANTINOCICEPTIVE AGENT; FLUOROCITRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; MORPHINE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BONE CANCER PAIN; BONE DESTRUCTION; CANCER PAIN; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; EVOKED RESPONSE; GLIA; HYPERALGESIA; MALE; MOUSE; NERVOUS SYSTEM PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SARCOMA CELL; SPINAL ASTROCYTE ACTIVATION; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BONE NEOPLASMS; CELL LINE, TUMOR; GLIAL FIBRILLARY ACIDIC PROTEIN; HINDLIMB; HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA; PAIN MEASUREMENT; PAIN, INTRACTABLE; PHYSICAL STIMULATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD;

EID: 84655162721     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31823de68d     Document Type: Article

References (47)

1. Colvin L, Fallon M: Challenges in cancer pain management: Bone pain. Eur J Cancer 2008; 44:1083-90
2. Mercadante S: Malignant bone pain: Pathophysiology and treatment. Pain 1997; 69:1-18 (Pubitemid 27081402)
3. Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR: Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res 2000; 861:105-16 (Pubitemid 30177288)
4. Dolan S, Nolan AM: Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission. Neuropharmacology 2000; 39:1132-8 (Pubitemid 30173178)
5. Dolan S, Nolan AM Transient up-regulation of metabotropic glutamate receptor mRNAs in spinalcord following surgical inflammation. Eur J Neurosci 2001 13 86
6. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53:55-63 (Pubitemid 24238751)
7. Coderre TJ, Van Empel I: The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests. Pain 1994; 59:345-52
8. Conn PJ, Pin JP: Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997; 37:205-37 (Pubitemid 27238875)
9. Neugebauer V: Metabotropic glutamate receptors: Important modulators of nociception and pain behavior. Pain 2002; 98:1-8 (Pubitemid 34722463)
10. Simmons RM, Webster AA, Kalra AB, Iyengar S: Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats. Pharmacol Biochem Behav 2002; 73:419-27 (Pubitemid 34765579)
11. Li W, Neugebauer V: Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. J Neurophysiol 2006; 96:1803-15 (Pubitemid 44527437)
12. Yang D, Gereau RW 4th: Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation. Pain 2003; 106:411-7 (Pubitemid 37505889)
13. Du J, i Zhou S, Carlton SM Group II Metabotropic Glutamate Receptor Activation Attenuates Peripheral Sensitization in Inflammatory States. Neuroscience 2008 154 754-66
14. Neto FL, Castro-Lopes JM: Antinociceptive effect of a group II metabotropic glutamate receptor antagonist in the thalamus of monoarthritic rats. Neurosci Lett 2000; 296:25-8
15. Zhang T, Zhang J, Shi J, Feng Y, Sun ZS, Li H: Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity. Brain Res Bull 2009; 79:219-23
16. Neugebauer V: Peripheral metabotropic glutamate receptors: Fight the pain where it hurts. Trends Neurosci 2001; 24:550-2 (Pubitemid 32913375)
17. Karim F, Wang CC, Gereau RW 4th: Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci 2001; 21:3771-9 (Pubitemid 32466469)
18. Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R: Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology 2001; 40:1-9 (Pubitemid 33779794)
19. Furuse S, Kawamata T, Yamamoto J, Niiyama Y, Omote K, Watanabe M, Namiki A: Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain. ANESTHESIOLOGY 2009; 111:173-86
20. Aronica E, Gorter JA, Ijlst-Keizers H, Rozemuller AJ, Yankaya B, Leenstra S, Troost D: Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins. Eur J Neurosci 2003; 17:2106-18 (Pubitemid 36713971)
21. Schools GP, Kimelberg HK: mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats. J Neurosci Res 1999; 58:533-43 (Pubitemid 29530436)
22. Cai Z, Schools GP, Kimelberg HK: Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: Developmental changes of mGluR5 mRNA and functional expression. Glia 2000; 29:70-80 (Pubitemid 30031135)
23. Ciccarelli R, Sureda FX, Casabona G, Di Iorio P, Caruso A, Spinella F, Condorelli DF, Nicoletti F, Caciagli F: Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture. Glia 1997; 21:390-8 (Pubitemid 27526676)
24. Aronica E, van Vliet EA, Mayboroda OA, Troost D, da Silva FH, Gorter JA: Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy. Eur J Neurosci 2000; 12:2333-44 (Pubitemid 30497031)
25. Aronica E, Catania MV, Geurts J, Yankaya B, Troost D: Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes. Neuroscience 2001; 105:509-20 (Pubitemid 32728133)
26. Aronica E, Yankaya B, Jansen GH, Leenstra S, van Veelen CW, Gorter JA, Troost D: Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. Neuropathol Appl Neurobiol 2001; 27:223-37 (Pubitemid 32678675)
27. Mudo G, Trovato-Salinaro A, Caniglia G, Cheng Q, Condorelli DF: Cellular localization of mGluR3 and mGluR5 mRNAs in normal and injured rat brain. Brain Res 2007; 1149:1-13 (Pubitemid 46659884)
28. Winder DG, Conn PJ: Roless of metabotropic glutamate receptors in glial function and glial-neuronal communication. J Neurosci Res 1996; 46:131-7 (Pubitemid 26367538)
29. Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF: Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 1997; 71:225-35 (Pubitemid 27288136)
30. Watkins LR, Maier SF: Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 2002; 82:981-1011
31. Wieseler-Frank J, Maier SF, Watkins LR: Glial activation and pathological pain. Neurochem Int 2004; 45:389-95 (Pubitemid 38625629)
32. Vallejo R, Tilley DM, Vogel L, Benyamin R: The roles of glia and the immune system in the development and maintenance of neuropathic pain. Pain Pract 2010; 10:167-84
33. Zhang RX, Liu B, Wang L, Ren K, Qiao JT, Berman BM, Lao L: Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 2005; 118:125-36 (Pubitemid 41566591)
34. Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW: Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci 1999; 19:10886-97 (Pubitemid 30235733)
35. Gu X, Zhang J, Ma Z, Wang J, Zhou X, Jin Y, Xia X, Gao Q, Mei F: The roles of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. Eur J Pain 2010; 14:496-502
36. Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, Wilcox GL: Functional interactions between tumor and peripheral nerve: Morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain. J Neurosci 2001; 21:9355-66 (Pubitemid 33096879)
37. Walker K, Medhurst SJ, Kidd BL, Glatt M, Bowes M, Patel S, McNair K, Kesingland A, Green J, Chan O, Fox AJ, Urban LA: Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. Pain 2002; 100:219-29 (Pubitemid 35449234)
38. Constandil L, Pelissier T, Soto-Moyano R, Mondaca M, Sáez H, Laurido C, MunËæoz C, López N, Hernández A: Interleukin- 1beta increases spinal cord wind-up activity in normal but not in monoarthritic rats. Neurosci Lett 2003; 342:139-42 (Pubitemid 36570337)
39. Raghavendra V, Tanga FY, DeLeo JA: Complete Freunds adjuvant-induced peripheral inflamm- ation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 2004; 20:467-73 (Pubitemid 38969631)
40. Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA: Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 1999; 829:209-21 (Pubitemid 29251705)
41. Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR: Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 2003; 23:1026-40 (Pubitemid 36206195)
42. Sweitzer S, Martin D, DeLeo JA: Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001; 103: 529-39 (Pubitemid 32201938)
43. Takeda K, Sawamura S, Sekiyama H, Tamai H, Hanaoka K: Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. ANESTHESIOLOGY 2004; 100:1249-57 (Pubitemid 38541982)
44. Martin FC, Charles AC, Sanderson MJ, Merrill JE: Substance P stimulates IL-1 production by astrocytes via intracellular calcium. Brain Res 1992; 599:13-8 (Pubitemid 23024911)
45. Marchand F, Perretti M, McMahon SB: Role of the immune system in chronic pain. Nat Rev Neurosci 2005; 6:521-32 (Pubitemid 40942819)
46. Aumeerally N, Allen G, Sawynok J: Glutamate-evoked release of adenosine and regulation of peripheral nociception. Neuroscience 2004; 127:1-11 (Pubitemid 38829146)
47. Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR: Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci 2001; 21:2808-19 (Pubitemid 32298222)