A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

Pain

Volumn 152, Issue 4, 2011, Pages 833-843

  Hildebrand, Michael E ^a   Smith, Paula L ^a   Bladen, Chris ^b   Eduljee, Cyrus ^a   Xie, Jennifer Y ^c   Chen, Lina ^b   Fee Maki, Molly ^a   Doering, Clint J ^b   Mezeyova, Janette ^a   Zhu, Yongbao ^a   Belardetti, Francesco ^a   Pajouhesh, Hassan ^a   Parker, David ^a   Arneric, Stephen P ^a   Parmar, Manjeet ^a   Porreca, Frank ^c   Tringham, Elizabeth ^a   Zamponi, Gerald W ^b   Snutch, Terrance P ^a,d  

^a Zalicus Pharmaceuticals Ltd   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Calcium channel; Dorsal horn; Dorsal root ganglia; Neuropathic pain; Slow inactivation; Sodium channel

Indexed keywords

CALCIUM CHANNEL AFFECTING AGENT; CALCIUM CHANNEL T TYPE; GABAPENTIN; MORPHINE; SODIUM CHANNEL AFFECTING AGENT; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; Z 123212;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HOT PLATE TEST; HUMAN; HUMAN CELL; HYPERALGESIA; MALE; NERVE CELL EXCITABILITY; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION; SPINAL NERVE;

ACETANILIDES; ACRYLATES; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICS; CALCIUM CHANNELS, T-TYPE; CELL LINE, TRANSFORMED; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; GANGLIA, SPINAL; HEART; HUMANS; HYPERALGESIA; ION CHANNELS; MALE; MEMBRANE TRANSPORT MODULATORS; NEURAL INHIBITION; NEURALGIA; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; PIPERAZINES; RABBITS; RATS; RATS, WISTAR; SENSORY RECEPTOR CELLS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPINAL CORD; SPINAL NERVES; TETRODOTOXIN; TRANSFECTION;

EID: 79953050569     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.12.035     Document Type: Article

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