Alternative splicing in the voltage-sensing region of N-Type Ca v2.2 channels modulates channel kinetics

Journal of Neurophysiology

Volumn 92, Issue 5, 2004, Pages 2820-2830

  Lin, Yingxin ^a   McDonough, Stefan I ^b,c   Lipscombe, Diane ^a  

^a BROWN UNIVERSITY   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL N TYPE; PROTEIN SUBUNIT;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DROSOPHILA; EXON; GANGLION; GENETIC CONSERVATION; KINETICS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; GENETICS; HUMAN; PHYSIOLOGY;

ALTERNATIVE SPLICING; ANIMALS; CALCIUM CHANNELS, N-TYPE; CELL LINE; DROSOPHILA; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; PROTEIN SUBUNITS;

EID: 14844298726     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00048.2004     Document Type: Article

References (48)

1. Barrett CF, Liu L, and Rittenhouse AR. Arachidonic acid reversibly enhances N-type calcium current at an extracellular site. Am J Physiol Cell Physiol 280: C1306-1318, 2001.
2. Barry EL, Gesek FA, Froehner SC, and Friedman PA. Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha ID isoform by parathyroid hormone. Proc Natl Acad Sci USA 92: 10914-10918, 1995.
3. Bell TJ, Thaler C, Castiglioni AJ, Helton TD, and Lipscombe D. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41: 127-138, 2004.
4. Bezanilla F. The voltage sensor in voltage-dependent ion channels. Physiol Rev 80: 555-592, 2000.
5. Birnbaumer L, Qin N, Olcese R, Tareilus E, Platano D, Costantin J, and Stefani E. Structures and functions of calcium channel beta subunits. J Bioenerg Biomembr 30: 357-375, 1998.
6. Black DL. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell 103: 367-370, 2000.
7. Bourinet E, Soong TW, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi GW, Nargeot J, and Snutch TP. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci 1: 407-415, 1999.
8. Chen CF, and Hess P. Mechanism of gating of T-type calcium channels. J Gen Physiol 96: 603-630, 1990.
9. Colquhoun D. Practical analysis of single channel records. In: Microelectrode Techniques (2nd ed.), edited by Ogden D. Cambridge, UK: The Company of Biologists, 1994, p. 101-139.
10. Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, Tsien RW, and Catterall WA. Nomenclature of voltage-gated calcium channels. Neuron 25: 533-535, 2000.
11. Frazier CJ, Serrano JR, George EG, Yu X, Viswanathan A, Perez-Reyes E, and Jones SW. Gating kinetics of the alphal1 T-type calcium channel. J Gen Physiol 118: 457-470, 2001.
12. Garcia J, Gerber SH, Sugita S, Sudhof TC, and Rizo J. A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol 11: 45-53, 2004.
13. Grabowski PJ. Splicing regulation in neurons: tinkering with cell-specific control. Cell 92: 709-712, 1998.
14. Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC, and Williams ME. Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha A-containing high-voltage-activated calcium channels. Biophys J 76: 1384-1400, 1999.
15. 2+ channels. J Neurosci 22: 9331-9339, 2002.
16. Hering S. beta-Subunits: fine tuning of Ca(2+) channel block. Trends Pharmacol Sci 23: 509-513, 2002.
17. Hille B, Woodhull AM, and Shapiro BI. Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH. Philos Trans R Soc Lond B Biol Sci 270: 301-318, 1975.
18. Ihara Y, Yamada Y, Fujii Y, Gonoi T, Yano H, Yasuda K, Inagaki N, Seino Y, and Seino S. Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells. Mol Endocrinol 9: 121-130, 1995.
19. Ikeda SR and Dunlap K. Voltage-dependent modulation of N-type calcium channels: role of G protein subunits. Adv Second Messenger Phosphoprotein Res 33: 131-151, 1999.
20. + channel. Nature 423: 33-41, 2003.
21. Jones LP, DeMaria CD, and Yue DT. N-type calcium channel inactivation probed by gating-current analysis. Biophys J 76: 2530-2552, 1999.
22. Jones LP, Patil PG, Snutch TP, and Yue DT. G-protein modulation of N-type calcium channel gating current in human embryonic kidney cells (HEK 293). J Physiol 498: 601-610, 1997.
23. Jones LP, Wei SK, and Yue DT. Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels. J Gen Physiol 112: 125-143, 1998.
24. Krovetz HS, Helton TD, Crews AL, and Home WA. C-Terminal alternative splicing changes the gating properties of a human spinal cord calcium channel alpha 1A subunit. J Neurosci 20: 7564-7570, 2000.
25. Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, and Alewood PF. Novel omega-conotoxins from Conns catus discriminate among neuronal calcium channel subtypes. J Biol Chem 275: 35335-35344, 2000.
26. Ligon B, Boyd AE 3rd, and Dunlap K. Class A calcium channel variants in pancreatic islets and their role in insulin secretion. J Biol Chem 273: 13905-13911, 1998.
27. 2+ channel in rat sympathetic ganglia and brain. Neuron 18: 153-166, 1997.
28. Lin Z, Lin Y, Schorge S, Pan JQ, Beierlein M, and Lipscombe D. Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons. J Neurosci 19: 5322-5331, 1999.
29. Lipscombe D and Castiglioni, A. J. Alternative splicing in voltage-gated calcium channels. Calcium Channel Pharmacology. In: Calcium Channel Pharmacology (1st ed.), edited by McDonough SI. New York: Kluwer/Academic/Plenum, 2004, p. 369-409.
30. Lipscombe D, Pan JQ, and Gray AC. Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1. Mol Neurobiol 26: 21-44, 2002.
31. McDonough SI. Peptide toxin inhibition of voltage-gated calcium channels: selectivity and mechanisms. In: Calcium Channel Pharmacology (1st ed.), edited by McDonough SI. New York: Kluwer/Academic/Plenum Publishing, 2004, p. 95-142.
32. McDonough SI, Mintz IM, and Bean BP. Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA. Biophys J 72: 2117-2128, 1997.
33. Nakai J, Adams BA, Imoto K, and Beam KG. Critical roles of the S3 segment and S3-S4 linker of repeat 1 in activation of L-type calcium channels. Proc Natl Acad Sci USA 91: 1014-1018, 1994.
34. 2+ channels. J Gen Physiol 108: 143-155, 1996.
35. Pan JQ and Lipscombe D. Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific. J Neurosci 20: 4769-4775, 2000.
36. Peixoto AA, Smith LA, and Hall JC. Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene. Genetics 145: 1003-1013, 1997.
37. Perez-Reyes E, Wei XY, Castellano A, and Birnbaumer L. Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes. J Biol Chem 265: 20430-20436, 1990.
38. 2+ channels. J Biol Chem 271: 3207-3212, 1996.
39. Smith LA, Peixoto AA, Kramer EM, Villella A, and Hall JC. Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila. Genetics 149: 1407-1426, 1998.
40. Smith LA, Wang X, Peixoto AA, Neumann EK, Hall LM, and Hall JC. A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci 16: 7868-7879, 1996.
41. Snutch TP, Tomlinson WJ, Leonard JP, and Gilbert MM. Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS. Neuron 7: 45-57, 1991.
42. Starr TV, Prystay W, and Snutch TP. Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc Natl Acad Sci USA 88: 5621-5625, 1991.
43. Stotz SC and Zamponi GW. Identification of inactivation determinants in the domain IIS6 region of high voltage-activated calcium channels. J Biol Chem 276: 33001-33010, 2001.
44. 2+ channel mRNAs. J Mol Cell Cardiol 29: 3035-3042, 1997.
45. 2+ channel current in Xenopus oocytes. J Physiol 517: 659-672, 1999.
46. 2+ channels: role in channel function. Trends Neurosci 21: 148-154, 1998.
47. 2+ channel complex purified from brain. Science 261: 486-489, 1993.
48. Zagotta WN, Brainard MS, and Aldrich RW. Single-channel analysis of four distinct classes of potassium channels in Drosophila muscle. J Neurosci 8: 4765-4779, 1988.