Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor

Drug Metabolism and Disposition

Volumn 40, Issue 1, 2012, Pages 178-186

  Lau, Aik Jiang ^a   Yang, Guixiang ^a   Rajaraman, Ganesh ^b,d   Baucom, Christie C ^c   Chang, Thomas K H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CellzDirect Life Technologies   (United States)

^c CellzDirect Life Technologies   (United States)

^d NoAb BioDiscoveries Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; BILOBALIDE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 2B1; CYTOCHROME P450 2B6; CYTOCHROME P450 3A; CYTOCHROME P450 3A23; CYTOCHROME P450 3A4; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; REPORTER GENE;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; CYCLOPENTANES; FURANS; GINKGOLIDES; HEP G2 CELLS; HEPATOCYTES; HUMANS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SPECIES SPECIFICITY;

EID: 84455163151     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042879     Document Type: Article

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